Testosterone Supplementation instead of Replacement - Experiment

[dikow]

Not exactly. Androgens also feedback negatively on GnRH & LH secretion, but are not as potent as E2. I don't understand the logic that very small doses of supplemental T will convert at a slower rate (mg for mg) than larger doses. As far as I know, the conversion follows enzyme mediated mass-action kinetics. The more substrate you feed the enzyme, the more it will convert until the enzyme is saturated, at which point conversion rate (mg for mg) will drop off.

To the second point, I believe controlling E2 is a wise move if you have labs to show that your E2 is high or out of range. However, playing with a necessary hormone without understanding baseline values with labs is not something I recommend. Honestly though, I wish you the best of luck with your experiment.

Youthful55guy and kelkel, what are your thoughts on the possible exogenous estrogen intake we acquire through contaminated water with hormones, meat, pesticides and so forth? Wouldn't this extra estrogen, such as xenoestrogens contribute to pituitary shutdown prematurely?

I've read some research papers saying this is one of the reasons of delayed puberty in men and also why adults with less testosterone than in previous generations. Men are getting more and more feminine every generation according to some studies.

The main reason I wanted to do this experiment was to counter act the effect of these types of issues. A little bit more test per day to balance the extra estrogen we get from eating/drinking etc.

Regarding controlling my E, would you recommend the use of an AI for such low doses of T?

Cheers.