No doubt about Nandrolone ( or other AAS ) cardiac damage

[Ernst]

No doubt? On rats? With sky high heart bpm?

Why animal studies are often poor predictors of human reactions to exposure: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746847/

Maybe you should have read some of the studies that were referenced by the author. The ones on humans. The author also incorrectly claims similar findings from another, similar study on humans-- but it was also on rats. Oops.

Here's one they referenced that actually was on humans. How about dem apples:
"In Study 1 eight weeks AAS self-administration did not result in changes of blood pressure or cardiac size and function. Additionally, duration of AAS self-administration did not have any impact on these parameters. Study 2 revealed that eight weeks administration of nandrolone decanoate did not induce significant alterations in blood pressure and heart morphology and function. Short-term administration of AAS for periods up to 16 weeks did not lead to detectable echocardiographic alterations of heart morphology and systolic and diastolic function in experienced strength athletes. The administration regimen used nor the length of AAS abuse did influence the results. Moreover, it is concluded that echocardiographic evaluation may provide incomplete assessment of the actual cardiac condition in AAS users since it is not sensitive enough to detect alterations at the cellular level. Nevertheless, from the present study no conclusions can be drawn of the cardiotoxic effects of long term AAS abuse." --Hartgens et al., 2003



I have little doubt that AAS contributes to cardiac hypertrophy in humans-- that's just common sense. However your thread title is straight up fake news clickbait.

[Slacker78]

No doubt? On rats? With sky high heart bpm?

Why animal studies are often poor predictors of human reactions to exposure: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746847/

Maybe you should have read some of the studies that were referenced by the author. The ones on humans. The author also incorrectly claims similar findings from another, similar study on humans-- but it was also on rats. Oops.

Here's one they referenced that actually was on humans. How about dem apples:
"In Study 1 eight weeks AAS self-administration did not result in changes of blood pressure or cardiac size and function. Additionally, duration of AAS self-administration did not have any impact on these parameters. Study 2 revealed that eight weeks administration of nandrolone decanoate did not induce significant alterations in blood pressure and heart morphology and function. Short-term administration of AAS for periods up to 16 weeks did not lead to detectable echocardiographic alterations of heart morphology and systolic and diastolic function in experienced strength athletes. The administration regimen used nor the length of AAS abuse did influence the results. Moreover, it is concluded that echocardiographic evaluation may provide incomplete assessment of the actual cardiac condition in AAS users since it is not sensitive enough to detect alterations at the cellular level. Nevertheless, from the present study no conclusions can be drawn of the cardiotoxic effects of long term AAS abuse." --Hartgens et al., 2003



I have little doubt that AAS contributes to cardiac hypertrophy in humans-- that's just common sense. However your thread title is straight up fake news clickbait.

"In Study 2 the effects of administration of nandrolone decanoate (200 mg/wk i. m.) for eight weeks..."

200mg/week VS: nandrolone (5 mg/kg) was administered to Vehicle-treated (vehicle = propylene glycol) or Nandrolone Decanoate-treated rats (Deca-Durabolin®, Organon, São Paulo, Brazil), twice a week, for 6 weeks as the study i posted told.

So...if you do a simple calculation keeping in mind that a rat could weights ~250/300gr, are ~800mg/week, so almost a robust dose an AAS user could assume in a AAS cycle... very far from 200mg/week.

Yes, the study is on a rats, but cardiac effects - especially nandrolone-related - on a humans are well documented also... you will tell... "and then ? You can damage your heart, if you don't want risk don't use them". But my thread was just speculative.