Quote Originally Posted by Youthful55guy View Post
To my knowledge, there is no research supporting that statement. My guess is that it's gym lore and probably has no basis in research. I simply don't believe it. Dosing weekly goes contrary to my general philosophy of TRT, which is to prevent the rollercoaster ride with smaller and more frequent dosing. That should control E better and we suspect that high E is one of the factors will drive up SHBG (though I have no references for this).

The drugs you mention have a bad rap with the AMA because they are prone to anabolic steroid abuse. Whenever you misuse drugs, the side-effects go up. Bodybuilders often use 40-100 mg of Winstrol or Anavar per day to achieve their desired effect. At that level, there is MUCH research showing that liver damage is inevitable. That is the main reason they cycle it to allow repair of the damage. My experience is that for SHBG lowering effects you need much small doses (in the 5-10 mg per day range). My experience also shows that my liver labs generally stay within normal when I dose at these low rates. It's only when I add other OTC analgesics to the mix where my liver labs go out of range.
Thanks man.....I would keep coming across the comment "1x per would keep SHBG lower vs. 2x per week" but could never find a studies or even a member showing labs to prove this. Totally agree orals or AA being abused gets a bad rap. I may go to a new TRT doc, I've heard he's willing to prescribe Anavar at 5-10mg- if not might order some Proviron from a friend in Europe, I hear its easily available there.