Quote Originally Posted by cousinmuscles View Post
It may increase IGF1 a little (assuming naturally produced estradiol works the same way as topical, which I think I have read before, but oral estrogen can have opposite e but if you use nolvadex it will be more than negated.) https://academic.oup.com/edrv/article/25/5/693/2355205 But people don't report small increases in IGF1 to do anything in terms of gains.

The feedback inhibition and increased IGF production of high estrogen can be pronounced with a triple stack of GHRP, GHRH and infused somatostatin and there is a study done on this specifically, and they used exogenous test to make for conversion to E2.

The above sentence sounds cool if you like to hang on to the balls of e.g. GH and cheer for him and his fake avatar. Why? because it is a stupid idea which nobody would do in real life. For one you'll feel like crap. You'll be walking around bloated, with high blood pressure. You'll increase risk of heart attacks and increase the risks of blood clots forming. So yeah if you have never done a cycle or even lift but want to sound cool on a forum you can claim high estrogen works. (GH didn't know about that study though and though high estrogen alone increases IGF...). If anyone claims high estrogen works then just show them data that estrogen works against free testosterone since it binds to the androgen receptor.
Yeah its most likely the case that estrogen at really high levels hinders gains. But the thing is, like obs first post, i still like to look into this stuff. I was out of the game for a while. When i came back in, there was so much bro science that i never heard of, and alot of which made no sense to me. Alot of it still doesnt. But its preached like gospel around the damn internet and chat rooms, forums, etc.

GH went overboard with some of the things he said. I prefer to speak from experience, and even if its not science trial backed evidence, i will believe my own eyes over anything i ever read on the internet. Which is why i am always up to try something, no matter how stupid it may sound, or how futile the effort. Then in my head, im believing myself versus something i read.

So, im trying the idea of high estrogen hindering gains myself. Although im not gonna pull blood 4 times in a couple months to test the theory, im not doing it as a science based experiment, im doing it for my own info. I know my e2 is through the roof right now-i came off my deca run about 4 or 5 wks ago, dropped my ai about 6 wks ago, and still runnin 700mg/wk prop. I saw slow but steady gains up until about 2 wks ago. Then they seemed to have stopped almost altogether. I have been hittin it pretty hard, increased sets, good recovery times, etc, not all too different than my previous work, just increased a bit.
I dont get any sides whatsoever from high e so its a bit easier for me to do.
So started back on ai 4 days ago, gonna run .5 adex for 4 days then go back to .25 eod from there on, and see when it appears that things change. Then ill pull blood and see what levels look like at that point. If for no other reason, i will know for myself how it effects me, rathe than assume it affects me a certain way based in internet garbage, and have an idea first hand of the scale it affects my gains.