Use of MK-677 to boost GH and IGF-1

[fiddlesticks]

We measure IGF-1 because it's a relatively stable and easy to measure marker for GH release. The end goal is really to increase GH secretion, but GH is episodic and diurnal in it's release, so it's more difficult to measure. Therefore, we use IGF-1 as a segregate marker for GH. The hormone affects the production many other growth factors and processes in the body, all of which decline with age as the master hormone (GH) declines. If we can boost GH to more healthy levels, as they were when we were in or 20's or 30's, in theory, we should be able to improve on the age-related decline we see in our bodies as we get older.


So, injecting IGF-1 may be beneficial to some processes such as muscle and joint repair, but it's like a single trumpet play in a symphony of hormones and growth factors.

I think you misunderstood what I meant, GHRP peptides in general work more than MK. It's a solid improvement going from mk to say ghrp6.

It's also a huge leap going from GHRP to hexarelin. When I used hex 100mcg a day my IGF was way higher than 4iu of GH. Baffles me MK is so popular when hex is faaaar better.

[Youthful55guy]

I think you misunderstood what I meant, GHRP peptides in general work more than MK. It's a solid improvement going from mk to say ghrp6.

It's also a huge leap going from GHRP to hexarelin. When I used hex 100mcg a day my IGF was way higher than 4iu of GH. Baffles me MK is so popular when hex is faaaar better.

Not to belabor the discussion, but there are numerous choices in how to increase GH production. There are pros and cons to each and some we simply do not fully understand. For me, it's a matter of making my entire anti-aging protocol (including TRT) sustainable and affordable over the long-haul. I've used various injectable peptides (including hexarelin) alone and in various combinations for quite some time. I've come to the conclusion that mixing and injecting small batches of peptides and having to keep them refrigerated is not conducive to sustainability of the protocol. Then there's disposal of the syringes that keep piling up in my office (where I do my injections) to deal with. Not to mention visible to prying eyes.

I find oral dosing from a portable and easy to hide eye dropper very appealing and I plan to continue investigating this aspect of GH augmentation. it's all a matter of personal preferences.

[fiddlesticks]

Not to belabor the discussion, but there are numerous choices in how to increase GH production. There are pros and cons to each and some we simply do not fully understand. For me, it's a matter of making my entire anti-aging protocol (including TRT) sustainable and affordable over the long-haul. I've used various injectable peptides (including hexarelin) alone and in various combinations for quite some time. I've come to the conclusion that mixing and injecting small batches of peptides and having to keep them refrigerated is not conducive to sustainability of the protocol. Then there's disposal of the syringes that keep piling up in my office (where I do my injections) to deal with. Not to mention visible to prying eyes.

I find oral dosing from a portable and easy to hide eye dropper very appealing and I plan to continue investigating this aspect of GH augmentation. it's all a matter of personal preferences.

yeah its certainly not time friendly mixing the vials and all that fun stuff.

Amphetamine and likely ephedrine have strong GH releasing properties as well so maybe look into that.

Also T3 does as well - If I was you I see no harm in adding 12.5mcg x2 a day of t3

[mexecutioner]

yeah its certainly not time friendly mixing the vials and all that fun stuff.

Amphetamine and likely ephedrine have strong GH releasing properties as well so maybe look into that.

Also T3 does as well - If I was you I see no harm in adding 12.5mcg x2 a day of t3

Actually, amphetamine is a releaser of dopamine, a well known inhibitor of GH release. This is why you have to monitor growth of children on amphetamines for ADHD. Not the newest study, but you can easily google for other studies: https://www.nature.com/articles/pr19...df?origin=ppub.

[fiddlesticks]

Actually, amphetamine is a releaser of dopamine, a well known inhibitor of GH release. This is why you have to monitor growth of children on amphetamines for ADHD. Not the newest study, but you can easily google for other studies: https://www.nature.com/articles/pr19...df?origin=ppub.

Ive read that but also have read the direct opposite. I've also read that bupropion which is similar to amphetamine increases GH from exercise by extremely significant amounts, like 50%.

I think a logical way to examine this would be amphetamines/ephedrine increase metabolism and thus autophagy GH plays a role there.

[Family_guy]

yeah its certainly not time friendly mixing the vials and all that fun stuff.

Amphetamine and likely ephedrine have strong GH releasing properties as well so maybe look into that.

Also T3 does as well - If I was you I see no harm in adding 12.5mcg x2 a day of t3

Ya let’s do amphetamine to increase GH

[fiddlesticks]

Ya let’s do amphetamine to increase GH

Honestly at a low dose it's an interesting neuroprotective drug, has all kinds of weird properties.

[kelkel]

As far as I understand it..

Hex can only be used 2 weeks on 2 off from its extreme potency desensitizating the gh system

I've read up to 4 but it's probably a coin toss....

I find oral dosing from a portable and easy to hide eye dropper very appealing and I plan to continue investigating this aspect of GH augmentation. it's all a matter of personal preferences.

There's much to be said for simplicity.