I've mentioned a couple times that I layered in ~25 mg/day of oral MK-677 into my peptide protocol about 5 weeks ago to see if I could reduce my use of injected peptides to boost GH production. I finally got my lab results today from a blood draw taken after 4 weeks of use. Bottom line it works dam well!

A little background. My GH production has always been somewhat lacking. Never clinically low, but always in about the 30th to 75th percentile for my aged group as measured by IGF-1 (8 tests without GH supplementation over the past 7+ years). My goal is to get IGF-1 into the 50th percentile for a 25-35 year old man, which is around 200 ng/mL with LabCorp (normal range for us old guys is 49-188). The only time I've been able to do that is with about 2.6 IU/day GH.

I've been slowly increasing my dose of a peptide mix of Ipamorelin and CJC-1295 (no DAC). My current dose before layering the MK-677 was 900/300 mcg per day in 3 divided doses. That protocol yielded 168 ng/mL IGF-1 in my last test, which is about the same as when I was using 1 IU GH/day. Layering in the oral MK-677 on top of that (~12-15 mg 2X per day AM & PM) returned an IGF-1 value of 220 (equal to about 3 IU GH per day).

I think I'll dial the peptides back a bit to 600/200 mcg/day IPA/CJC-1295 and keep the MK-677 where it is and retest in about 4 weeks, then adjust the doses further if necessary. My goal is to maintain >200 ng/mL IGF-1, reduce the cost of the program, and dial back the injections to 2X per day (with a 31G insulin syringe).