I think it’s two fold. I’m parroting here so take this with a grain of salt. Like to give that caveat. From what I understand, the diphenhydramine down regulates beta receptors keeping the tolerance to clen from increasing. Benadryl slows desensitization of Beta receptors, so there is essentially a synergistic effect. The additional benefit is the anxiety and insomnia that comes with Clen and the diphenhydramine is also useful in circumventing those two sides.
yes this is true and often times why guys run Benadryl with Clen . however its completely unnecessary imo. the idea of Clen tolerance and de-sensitization is completely over blown in my opinion.. wither its Benadryl or doing something like 2 weeks on 2 weeks off, etc.. in an attempt to keep 'sensitized' to clen, its really not necessary. Clen does not magically stop working after a couple weeks of being on it.
take your resting heart rate. lets say its 70bpm.. then get on 60mcg of clen per day and now lets say its 90bpm. well if after 4 weeks your resting bpm is still 90bpm then the clen is still obviously working
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