I have been on 10g of Androgel for 3 months and 5g before that for a total of 6 months of TRT. I think I am having side effects now and I would like to know what can cause them. I am starting to get a little bit of acne on my shoulders not bad yet and I would like to keep it that way. What causes the acne and what can you do to clear up the problem? My nipples are bothering me they are sensitive and always hard. I thought it was just irritation from all the Androgel so I have been careful not to get the Androgel on the area but I still have the problem. My estridol was 28 at my last BW in February so that seems to be OK or can it shoot up in a couple of weeks?