Page 1 of 4 1234 LastLast
Results 1 to 40 of 126
Like Tree31Likes

Thread: Cialis and your Prostate: Understanding Prostate Issues, Prevention & Treatment

  1. #1
    austinite's Avatar
    austinite is offline HRT Specialist ~ AR-Platinum Elite-Hall of Famer ~
    Join Date
    Mar 2012
    Location
    Cialis, Texas
    Posts
    31,169

    Cialis and your Prostate: Understanding Prostate Issues, Prevention & Treatment

    Introduction

    Prostate health in men is often dismissed or overlooked. Lots of folks are working towards healthy blood counts and liver values, but the fact is that your prostate gland is highly affected. This may not be a big deal to you, but a lot of concern will be raised once you understand your prostate's purposes and the negative effects it can cause. Hopefully this article will serve to educate you further, and you'll be able to make a much more informed decision on how you handle your future cycles.

    What Exactly is the Prostate?

    Opposite of endocrine glands, this is an exocrine gland; such as the liver and adrenal glands. It's part of your reproductive system and it sits just under your bladder. The main reason this gland exists is to enhance the quality of sperm by secreting Prostate Specific Antigen fluids (PSA). The alkaline content in the fluids it produced in ejaculate protects the sperm because vaginal areas are acidic and can damage sperm. All the nerves that affect male erections wrap around the prostate.

    As mentioned earlier, the penile nerves are surrounding the prostate. These are the nerves that control our erections. Another reason to keep a healthy prostate because an unhealthy prostate could damage these nerves, inevitably leading to erectile dysfunction. Furthermore, being an actual muscle, it also controls the force of which your ejaculate content exits. A weak ejaculate would be an indication of a weak muscle. This is a "pumping" type action and it's the reason males feel "good" at the climax point.

    Kind of like the liver, it also acts as a filter to make sure your sperm stays healthy. Toxins can reach the prostate just like anything else, and the prostate will filter these toxins out. This is not only important for the sake of healthy sperm, but overall health as well because if filtration is hindered due to an unhealthy prostate, big complications can occur such as prostate cancer.

    Urinary infections are more likely in women than it is in men, but it's still possible and these infections start with an unhealthy prostate. Speaking of urinary issues, the prostate has 2 muscles called the "Sphincter" muscles. These exit to control the release of ejaculate and urine, where it literally turn valves on and off so that they are not released simultaneously.

    So that's your prostate and it's functions. Let's look at how steroids affect your prostate...

    How Anabolic Steroids Negatively Affect Your Prostate

    Earlier we mentioned that the prostate is a muscle. Continuous steroid use will eventually enlarge the prostate, as it would with anything else. This isn't a drastic increase but certainly something to consider if you plan on using anabolic steroids for extended periods. The truth is, as you age, your prostate will get bigger. This is why folks over 40 are always recommended to get it checked periodically. But there are some precautions we can take to delay this process as much as possible.

    Here's a quick study on an athlete that was using anabolic steroids and volunteered himself for this study. Please note that in the medical industry, any use of steroids that is not done under a doctors care is considered abuse. So don't let the word "abuse" scare you as it does not mean he was injecting several grams of anabolic steroids.


    STUDY: PMID: 7529633

    Steroid abuse in athletes, prostatic enlargement and bladder outflow obstruction.

    OBJECTIVE:
    To evaluate the effects of exogenous androgenic-anabolic steroids on the human prostate gland.

    SUBJECT AND METHODS:
    A white male athlete, who was routinely using anabolic steroids, volunteered for the study. He was studied during a 15-week period of steroid self-administration. Both objective and subjective parameters were measured, including: prostatic volume (transrectal ultrasound), digital rectal examination, urine flow rate, serum acid phosphatase and prostate specific antigen, symptom scoring for bladder outflow obstruction and other associated symptoms.

    RESULTS:
    During the period of steroid self-administration, prostatic volume increased and urine flow rate decreased. The man also noticed an increase in nocturnal urinary frequency, libido and aggression.

    CONCLUSION:
    In this pilot study, the administration of exogenous androgenic-anabolic steroids has been demonstrated to have profound effects on the human prostate gland, including an increase in prostatic volume, reduction in urine flow rate and an alteration in voiding patterns. These findings warrant further investigation.



    Now, some folks might object to some of the side effects from exogenous testosterone , however, the majority of the studies done (all that I have seen) compared endogenous testosterone serum, not exogenous. So they're really not a fair assessment considering your natural production is generally balanced. By balanced, I don't mean that your levels are in range. What I mean is that your body has become accustomed to the level and adapted to operate functionally. In other words, your prostate doesn't really freak out with different natural testosterone levels .

    What are Signs of Prostate Related Problems

    You can look for certain signs that might indicate either an enlarged prostate and/or other underlying issues and concerns. This is mostly noticeable in your urine. Below you will find a list of common observations you can use to make a decision on whether you need to get your prostate checked:

    - Involuntary urination
    - Unable to urinate
    - Painful urination
    - Blood in urine
    - Very weak stream
    - Waking up several times to urinate

    The most common of the symptoms I mentioned above is the weak urine stream. So keep an eye on that. As for a painful urinary experience, you are likely to have some sort of infection. A CBC panel can sometimes identify an infection by observing your White Blood Cell (WBC) levels. If these are out of range, either too high or too low, would indicate that your body is fighting an infection.

    What is the Process of Testing the Prostate?

    There are several methods used to test the health of your prostate. Your doctor is likely to first order either blood work or a urinalysis. The following are common methods of testing the prostate:

    Prostate Specific Antigen test. (PSA test)
    -- This is done via a blood sample, and can identify abnormalities and cancer. I get this test several times per year.

    Checking urine flow
    -- Simple test of observing flow to see if it's strong, or weak where it would indicate an issue with fow.

    Urinalysis & Urine Culture
    -- A urine sample is analyzed for identifying any traces of blood and to check for infections under a microscope.

    Cystoscopy
    -- A telescope is used to observe the inside of your bladder.

    Rectal exam
    -- The one we hate the most. Doctor inserts gloved finger in your rectum to feel if prostate is enlarged.

    What Can I do to Prevent or Delay Complications?

    For most of us, if we do in fact have an enlarged prostate, it's more than likely a mild case. Sometimes not noticeable symptoms until it gets worse. But as promised, I'll give you some pointers to either reduce the enlargement and/or prevent and delay it.

    - Minimize alcohol and caffeine intake.
    - Avoid antihistamines.
    - Don't allow your body temperature to drop.
    - Avoid large water intake in one sitting.

    Supplementations you can use to help with this condition:

    I know lot's of folks, or thousands rather, use Saw Palmetto for reversing an enlarged prostate. Frankly, I don't see anything in saw palmetto that can aid with this condition. There have been both, positive and negative studies. There just isn't enough evidence to conclude its effectiveness.

    CIALIS! Although not over the counter, it's certainly readily available. Cialis is your best friend and will help you maintain a healthy prostate. If your PSA comes back high, Cialis can bring it down in a matter of weeks. It helps relax the muscle, too so it's not stressed or "under pressure". 5 mg a day at least is what I recommend. I personally take 10mg a day.

    I also recommend that you use Nettle Root Extract. This is an herb that can most certainly assist in prostate and urine flow obstruction related issues. For everyday use I recommend 500mg twice daily, for a total of 1 gram per day. In the event that you have any abnormalities, I would double that dose to 2 grams per day total.

    Furthermore on supplementations, I also recommend that you incorporate a minimum of 3 grams of vitamin C daily, 30 mg of zinc and introduce green tea into your daily liquid intake. Following these supplemental guidelines will certainly help with your urine flow and reduce swelling to a degree. If you looked at my supplement protocol, you'll notice that I already use all of these as part of my daily regimen. If you see nettle root missing from my protocol, it's because I drink Tisane tea, which is heavy with nettle.


    TADALAFIL (CIALIS)

    Tadalafil (Cialis) has been mentioned quite a bit recently on the forums. This is by far, one of my favorite drugs available today. When we hear of Cialis, generally we think of a pill for erectile dysfunction. This is true, as that was its initial purpose. However, over the years, Cialis has been proven to provide aid and health in many areas. Today we'l be discussing Cialis and all of its benefits. So let's get started...

    What is Cialis and how does it work?

    Cialis is a phosphodiesterase type 5 (PDE5) inhibitor. Phosphodiesterase (PDE) are different enzymes in our bodies that all come together and make up chemicals in the phosphate group (salts). Of all the PDE's in our bodies, it is the type 5 PDE that is of concern to us in regards to this topic. While dominant in PDE5 inhibition, it also inhibits PDE6.

    Stay with me here, this isn't easy to explain...

    Type 5 PDE breaks down and damages cyclic guanosine monophosphate (cGMP), which basically activates intracellular protein enzymes that regulate all of our cell pathways. These pathways are for signaling the activation of receptor proteins. This activation causes relaxation in the "smooth muscle" in the corpus cavernosum (inside the penis) and dilates the vessels leading up to it. Are you still with me or did I lose you?

    So to sum it all up, PDE5 is damaging to everything that our bodies need to generate an erection. By blocking PDE5, our body has the opportunity to function without disruption. That's why PDE5 inhibitors were invented. Like Cialis and Viagra. They block PDE5 and that enables us to have erections again.

    As you get older, you accumulate more and more PDE5 and/or cGMP diminishes. This is why it's common for older folks to experience impotence. Sometimes even in the presence of normal serum testosterone levels. In some cases, cGMP production diminishes, and that's why Cialis and other PDE5 inhibitors do not work very well in some folks. These folks would have to use more extreme measure, such as Trimix; the penile injection.

    What else can Cialis do for me?

    NITRIC OXIDE: One of the results of cGMP is to cause a chemical reaction with the nitric oxide synthase enzyme. This generates Nitric Oxide that increases the circumference of our vessels. Not only in and around the penis, but all over our bodies. This is what causes vascularity and gives you an incredible "pump" after a resistance training session. Nitric oxide has a very short life, so constant production is very important. It's great for the betterment of your cardiovascular system by increasing blood flow. By increasing Nitric Oxide levels, your blood is now flowing much better. This results in better oxygen delivery and other nutrients to your muscles and other tissue. Of course, the more nutrients they receive the healthier they will be.

    LOWER BLOOD PRESSURE: This drug will lower your blood pressure. This is not a drastic or dangerous decrease in blood pressure. Just enough to make it HIGHLY recommended for use during our steroid cycles. It is important to note that you should not use blood pressure medication while on Cialis. Unless of course, approved by your doctor. But generally, ACE inhibitors, alpha blockers and other forms are not recommended for coupling with Cialis.

    PROSTATE HEALTH: Cialis has been approved to treat enlarged prostates. In studies, they used as little as 5 mg daily to reduce inflammation of the prostate and bringing back to a normal state.


    STUDY: PMID: 23782459

    Effects of Tadalafil on Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia and on Erectile Dysfunction in Sexually Active Men with Both Conditions: Analyses of Pooled Data from Four Randomized, Placebo-Controlled Tadalafil Clinical Studies.

    INTRODUCTION:
    Erectile dysfunction (ED) and lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH) are common in aging males and frequently occur together. Tadalafil has demonstrated efficacy in treating both conditions.

    AIM:
    The study aims to evaluate the efficacy and safety of tadalafil 5 mg once daily vs. placebo over 12 weeks in treating both LUTS/BPH and ED in sexually active men. We also assessed relationships of baseline disease severity and prostate specific antigen (PSA) to outcomes.

    METHODS:
    Data were pooled from four multinational, randomized studies of men ≥45 years with LUTS/BPH, with analyses restricted to sexually active men with ED. Randomization (baseline) followed a 4-week placebo run-in; changes from baseline were assessed vs. placebo using analysis of covariance.

    MAIN OUTCOME MEASURES:
    International Prostate Symptom Score (IPSS), IPSS subscores, Quality-of-Life Index (IPSS-QoL), BPH Impact Index (BII), and International Index of Erectile Function-Erectile Function (IIEF-EF) Domain score were used in this study.

    RESULTS:
    Tadalafil (N = 505) significantly improved total IPSS vs. placebo (N = 521); mean changes from baseline were -6.0 and -3.6, respectively (P < 0.001). Improvements in IIEF-EF Domain score (tadalafil, 6.4; placebo, 1.4) were also significant vs. placebo, as were the IPSS storage and voiding subscores, IPSS-QoL, and BII (all P < 0.001). No significant impact of baseline ED severity or PSA category on IPSS response was observed (interaction P values, 0.463 and 0.149, respectively). Similarly, improvement in IIEF-EF Domain score was not significantly impacted by baseline LUTS/BPH severity or PSA category (interaction P values, 0.926 and 0.230, respectively). Improvements in IPSS and IIEF-EF Domain score during treatment were weakly correlated (r = -0.229). Treatment-emergent adverse events were consistent with previous reports.

    CONCLUSIONS:
    Tadalafil was efficacious and well tolerated in treating ED and LUTS/BPH in sexually active men with both conditions. Improvements in both conditions were significant regardless of baseline severity. Improvements in the total IPSS and the IIEF-EF Domain score were weakly correlated.



    As mentioned in the study above, Cialis can treat benign prostatic hyperplasia (BPH). This FDA approved. Click here to see the release...

    How does Cialis compare to Viagra?

    Cialis is far superior than Viagra. Viagra is fairly short lived, where the effects diminish in a matter of hours. Furthermore, Viagra can cause constant erection so long as it's in your system. This may sound good for some, but for me that can be quite annoying. Imagine lifting at the gym and suddenly you become erect. I'd rather come to an erection when stimulated only. Which is what Cialis does. The good news is, that once you climax/ejaculate, you'll be able to perform once again very shortly after. This is due to it's long half life.


    STUDY: PMID: 15709885

    Comparison of clinical trials with sildenafil, vardenafil and tadalafil in erectile dysfunction.

    Abstract
    Erectile dysfunction (ED) affects up to 50% of men, between 40 and 70 years of age. In the first major trial of sildenafil in ED, at 24 weeks, improved erections were reported by 77 and 84% of men taking sildenafil 50 and 100mg, respectively. Subsequently, sildenafil has been reported to be effective in men with ED associated with diabetes and prostate cancer, and in psychogenic ED. Sildenafil is safe in men with coronary artery disease, provided it is not used with the nitrates (a contraindication). The most commonly reported adverse effects with sildenafil are headache, flushing and dyspepsia.

    Vardenafil is more potent and more selective than sildenafil at inhibiting phosphodiesterase-5. Vardenafil is similarly effective to sildenafil in the treatment of ED. The only advantage that vardenafil has over sildenafil is that it does not inhibit phosphodiesterase-6 to alter colour perception, a rare side effect which sometimes occurs with sildenafil. Tadalafil has a longer duration of action than sildenafil and vardenafil. Tadalafil is similarly effective as sildenafil in the treatment of ED. In comparison studies, tadalafil is preferred to sildenafil (50/100mg) by men with ED, possibly because of its longer duration of action. Of the phosphodiesterase inhibitors, tadalafil may displace sildenafil as the drug of choice among men with ED.



    Austinite's dosage and protocol recommendation:

    My personal protocol is 5 mg administered twice daily; for a total of 10 mg per day. There is no reason to split the dose up, however, the reason I split is because I only want 5 mg as part of my pre workout.

    - If you're under 30 years of age. I recommend 5 mg daily.
    - If you're over 30 years of age, I recommend 10 mg daily.

    Anyone under 18 should not be using this drug and frankly, teenagers don't need it.

    That's all I have for you. Have a powerful day,

    ~ Austinite
    Last edited by austinite; 08-10-2013 at 12:16 PM.
    ~ PLEASE DO NOT ASK FOR SOURCE CHECKS ~

    "It's human nature in a 'more is better' society full of a younger generation that expects instant gratification, then complain when they don't get it. The problem will get far worse before it gets better". ~ kelkel

  2. #2
    marcus300's Avatar
    marcus300 is offline ~Retired~ AR-Platinum Elite-Hall of Famer ~
    Join Date
    Jan 2005
    Location
    ENGLAND
    Posts
    40,921
    Excellent aus. Great read.

    What do you suggest to the members who suffer slight negative sides to C like nasal congestion and headaches ect. Take during the night or lower dose?

  3. #3
    ppwc1985's Avatar
    ppwc1985 is offline Productive Member
    Join Date
    Jun 2012
    Location
    CT
    Posts
    1,926
    Very informative, thanks austinite

  4. #4
    toilet is offline Banned
    Join Date
    Nov 2012
    Posts
    201
    is the ar-r equivalent just as good or

  5. #5
    austinite's Avatar
    austinite is offline HRT Specialist ~ AR-Platinum Elite-Hall of Famer ~
    Join Date
    Mar 2012
    Location
    Cialis, Texas
    Posts
    31,169
    Quote Originally Posted by marcus300 View Post
    Excellent aus. Great read.

    What do you suggest to the members who suffer slight negative sides to C like nasal congestion and headaches ect. Take during the night or lower dose?
    Thanks, Marcus.

    You know, from my experience and talking to others, the congestion issues go away after a couple weeks. As a preventative measure, it's a good idea to start at a lower dose. However, one of the best remedies I have is L-Cysteine + Vitamin C. The amino acid will liquify mucus and clean up respitory issues quickly. (Even smokers). Coupled with Vitamin C it is a surefire way to clear you up quickly.

    I recommend 2 grams of L-Cysteine daily, and 2 grams of Vitamin C daily. One of each on the morning, then again at night. Headaches tend to go away faster once vessels are dilated.
    marcus300, NACH3, Nixter and 1 others like this.
    ~ PLEASE DO NOT ASK FOR SOURCE CHECKS ~

    "It's human nature in a 'more is better' society full of a younger generation that expects instant gratification, then complain when they don't get it. The problem will get far worse before it gets better". ~ kelkel

  6. #6
    jasc's Avatar
    jasc is offline Welcome to the Good Life
    Join Date
    Jul 2011
    Posts
    8,319
    Excellent read Aus

    Thank you

  7. #7
    BluPhin's Avatar
    BluPhin is offline Associate Member
    Join Date
    Mar 2013
    Posts
    339
    Good info. Your always looking out for us. Thanks bro!

  8. #8
    austinite's Avatar
    austinite is offline HRT Specialist ~ AR-Platinum Elite-Hall of Famer ~
    Join Date
    Mar 2012
    Location
    Cialis, Texas
    Posts
    31,169
    Appreciate the comments folks.
    ~ PLEASE DO NOT ASK FOR SOURCE CHECKS ~

    "It's human nature in a 'more is better' society full of a younger generation that expects instant gratification, then complain when they don't get it. The problem will get far worse before it gets better". ~ kelkel

  9. #9
    austinite's Avatar
    austinite is offline HRT Specialist ~ AR-Platinum Elite-Hall of Famer ~
    Join Date
    Mar 2012
    Location
    Cialis, Texas
    Posts
    31,169
    Quote Originally Posted by ppwc1985 View Post
    Very informative, thanks austinite
    Quote Originally Posted by jasc View Post
    Excellent read Aus

    Thank you
    Quote Originally Posted by BluPhin View Post
    Good info. Your always looking out for us. Thanks bro!
    Enjoy fellas, thank you for tuning in.
    ~ PLEASE DO NOT ASK FOR SOURCE CHECKS ~

    "It's human nature in a 'more is better' society full of a younger generation that expects instant gratification, then complain when they don't get it. The problem will get far worse before it gets better". ~ kelkel

  10. #10
    Join Date
    May 2011
    Location
    Europa
    Posts
    553
    Any known side effects ? Maybe other than those which could appear in people with low blood pressure ?
    How about coming off it after a long time of usage ? Could some issues appear ?

  11. #11
    austinite's Avatar
    austinite is offline HRT Specialist ~ AR-Platinum Elite-Hall of Famer ~
    Join Date
    Mar 2012
    Location
    Cialis, Texas
    Posts
    31,169
    Quote Originally Posted by JimmySidewalk View Post
    Any known side effects ? Maybe other than those which could appear in people with low blood pressure ?
    How about coming off it after a long time of usage ? Could some issues appear ?
    The list of side effects are as follow, although uncommon:

    Headaches
    dyspepsia
    back pain
    myalgia
    nasal congestion
    flushing
    limb pain

    I've only experienced congestion, but fixed that quickly with L-Cysteine and vitamin C. I take Benicar and have no issues with BP.
    ~ PLEASE DO NOT ASK FOR SOURCE CHECKS ~

    "It's human nature in a 'more is better' society full of a younger generation that expects instant gratification, then complain when they don't get it. The problem will get far worse before it gets better". ~ kelkel

  12. #12
    austinite's Avatar
    austinite is offline HRT Specialist ~ AR-Platinum Elite-Hall of Famer ~
    Join Date
    Mar 2012
    Location
    Cialis, Texas
    Posts
    31,169
    Pharmacokinetic evaluation of sildenafil as a pulmonary hypertension treatment.

    Introduction: Sildenafil citrate is a potent, selective phosphodiesterase type 5 inhibitor approved for the treatment of pulmonary arterial hypertension (PAH) and plays an important role in the management of the disease. Areas covered: In this review, we focus on the current available information on the pharmacokinetics, pharmacodynamics, clinical efficacy and safety of sildenafil citrate in PAH through a MEDLINE literature search. Comparison of sildenafil citrate with tadalafil, another phosphodiesterase type 5 inhibitor was also performed.

    Expert opinion: In the last few years, considerable progress has been made in the understanding and treatment of PAH. Sildenafil citrate has multiple advantages and whether it is first-line treatment alone or in combination for the mild form of the disease, it is one of the treatments of choice. In terms of its future use, more studies are still needed to better evaluate the benefit/risk balance of sildenafil citrate in pediatric populations.

    June 12th, 2013

    Pharmacokinetic evaluation of... [Expert Opin Drug Metab Toxicol. 2013] - PubMed - NCBI
    basketballfan22 likes this.
    ~ PLEASE DO NOT ASK FOR SOURCE CHECKS ~

    "It's human nature in a 'more is better' society full of a younger generation that expects instant gratification, then complain when they don't get it. The problem will get far worse before it gets better". ~ kelkel

  13. #13
    Trevtrev's Avatar
    Trevtrev is offline Associate Member
    Join Date
    Jun 2013
    Posts
    435
    Quote Originally Posted by toilet View Post
    is the ar-r equivalent just as good or
    Good question. Anyone with experience?

  14. #14
    austinite's Avatar
    austinite is offline HRT Specialist ~ AR-Platinum Elite-Hall of Famer ~
    Join Date
    Mar 2012
    Location
    Cialis, Texas
    Posts
    31,169
    ^ 100%. Absolutely equivalent and wow, so cost effective. 900mg bottle is a 90 day supply (10mg daily) for $60 (that's not even on sale), you can't get 5 pills for that price.
    ~ PLEASE DO NOT ASK FOR SOURCE CHECKS ~

    "It's human nature in a 'more is better' society full of a younger generation that expects instant gratification, then complain when they don't get it. The problem will get far worse before it gets better". ~ kelkel

  15. #15
    redhawk01's Avatar
    redhawk01 is offline Member
    Join Date
    Jun 2012
    Posts
    581
    Quote Originally Posted by austinite
    ^ 100%. Absolutely equivalent and wow, so cost effective. 900mg bottle is a 90 day supply (10mg daily) for $60 (that's not even on sale), you can't get 5 pills for that price.
    Most def will check that out. After I got my 30 day free trial of CIA, at 5mgs per, my refill for 30 was 187.00, no insurance. They would only do 15 days at 5mgs, 25 bucks. Wtf?

  16. #16
    Captncavematt's Avatar
    Captncavematt is offline Junior Member
    Join Date
    Jul 2013
    Location
    Rural BFE
    Posts
    83
    Great info. Thanks. I am contemplating how Cialis would best be used while on cycle for prostate protection. Should it just be run with cycle, preloaded, run on into or through PCT?
    Thanks.

  17. #17
    austinite's Avatar
    austinite is offline HRT Specialist ~ AR-Platinum Elite-Hall of Famer ~
    Join Date
    Mar 2012
    Location
    Cialis, Texas
    Posts
    31,169
    Quote Originally Posted by Captncavematt View Post
    Great info. Thanks. I am contemplating how Cialis would best be used while on cycle for prostate protection. Should it just be run with cycle, preloaded, run on into or through PCT?
    Thanks.
    Yes, on or off cycle. 10mg a day will protect you. I never come off of Cialis.
    NACH3 likes this.
    ~ PLEASE DO NOT ASK FOR SOURCE CHECKS ~

    "It's human nature in a 'more is better' society full of a younger generation that expects instant gratification, then complain when they don't get it. The problem will get far worse before it gets better". ~ kelkel

  18. #18
    Brazensol's Avatar
    Brazensol is offline Productive Member~ Recognized Member Winner - $100
    Join Date
    Jun 2012
    Posts
    1,496
    Just ordered some to augment my daily 2.5mg (pitiful, I know) from the doc.

    The good news is the bottle will now last me 120 days... One of the better deals I've seen on A-R-R.

  19. #19
    chi's Avatar
    chi
    chi is offline Knowledgeable Member
    Join Date
    Jan 2011
    Location
    corruption
    Posts
    1,782
    great read!!! thanks for the info

  20. #20
    bigsiv's Avatar
    bigsiv is offline Productive Member
    Join Date
    May 2012
    Location
    North east England
    Posts
    1,625
    Another great read austinite thanks for taking the time to put this together

  21. #21
    dreadnok89 is offline Member
    Join Date
    Sep 2012
    Posts
    978
    Not to be stupid but is androgel anabolic steroid ?

  22. #22
    austinite's Avatar
    austinite is offline HRT Specialist ~ AR-Platinum Elite-Hall of Famer ~
    Join Date
    Mar 2012
    Location
    Cialis, Texas
    Posts
    31,169
    Quote Originally Posted by dreadnok89 View Post
    Not to be stupid but is androgel anabolic steroid?
    yes.
    ~ PLEASE DO NOT ASK FOR SOURCE CHECKS ~

    "It's human nature in a 'more is better' society full of a younger generation that expects instant gratification, then complain when they don't get it. The problem will get far worse before it gets better". ~ kelkel

  23. #23
    Brazensol's Avatar
    Brazensol is offline Productive Member~ Recognized Member Winner - $100
    Join Date
    Jun 2012
    Posts
    1,496
    Will the extra 7.5 mgs/day make a noticeable difference in vascularity? Currently on 2.5mgs daily...

  24. #24
    austinite's Avatar
    austinite is offline HRT Specialist ~ AR-Platinum Elite-Hall of Famer ~
    Join Date
    Mar 2012
    Location
    Cialis, Texas
    Posts
    31,169
    In time it will. As you lower your BF and your nitric Oxide levels climb it will certainly be more effective in that department.
    ~ PLEASE DO NOT ASK FOR SOURCE CHECKS ~

    "It's human nature in a 'more is better' society full of a younger generation that expects instant gratification, then complain when they don't get it. The problem will get far worse before it gets better". ~ kelkel

  25. #25
    austinite's Avatar
    austinite is offline HRT Specialist ~ AR-Platinum Elite-Hall of Famer ~
    Join Date
    Mar 2012
    Location
    Cialis, Texas
    Posts
    31,169
    Insulin-like effect of the phosphodiesterase type 5 inhibitor tadalafil onto male human skeletal muscle cells

    Background: Phosphodiesterase type 5 inhibitors (PDE5i), widely used to treat male erectile dysfunction, seem to counteract insulin resistance (IR) in animals and humans. IR, primarily manifest in peripheral tissues and particularly in skeletal muscle, is due to impaired insulin signal transduction. Investigators have been focusing onto intracellular defects responsible for IR to identify suitable pharmacological tools targeted toward the specific defects. Albeit some effects of PDE5i have been reported onto animal muscular tissues or cells, whether and how they might affect metabolic processes directly in human skeletal muscle still remains unclear.

    Aim: We aimed to investigate in human fetal skeletal muscle cells (Hfsmc) the effect of tadalafil, one of PDE5i, onto some intracellular factors involved in response to insulin, such as ras-raf mitogen activated protein kinase (MAPK), phosphatidylinositol 3- kinase/protein kinase B (PKB/Akt), glycogen synthase kinase 3β (GSK-3β), and the transcriptional factor c-Myc; proliferation rate; lactate (lact) and free fatty acid (ffa) release; activity of citrate synthase (CS) and succinate dehydrogenase (SDH), both enzymes of Kreb's cycle; PDE5 gene expression.

    Materials and Methods: Western blot analysis, ELISA, enzymatic assays, cell count, MTT assay and Real Time PCR were performed in Hfsmc with and without tadalafil. Results In Hfsmc tadalafil affected the insulin-related intracellular cascade, by increasing MAPK, PKB/Akt, GSK-3β phosphorylation and c-Myc expression. Ffa release and CS activity also significantly increased, with no changes in SDH activity and lact release.

    Conclusions: Tadalafil, like insulin, targeted part of the machinery dedicated to energy management and metabolic control in human skeletal muscle cells.

    Insulin-like effect of the phosphodieste... [J Endocrinol Invest. 2013] - PubMed - NCBI
    basketballfan22 likes this.
    ~ PLEASE DO NOT ASK FOR SOURCE CHECKS ~

    "It's human nature in a 'more is better' society full of a younger generation that expects instant gratification, then complain when they don't get it. The problem will get far worse before it gets better". ~ kelkel

  26. #26
    Brazensol's Avatar
    Brazensol is offline Productive Member~ Recognized Member Winner - $100
    Join Date
    Jun 2012
    Posts
    1,496
    Any reason females can't cialis?

  27. #27
    austinite's Avatar
    austinite is offline HRT Specialist ~ AR-Platinum Elite-Hall of Famer ~
    Join Date
    Mar 2012
    Location
    Cialis, Texas
    Posts
    31,169
    Well, women would have the same effects as men as far as increased NO levels, lower BP, better blood flow, etc... but it won't do anything really for a females libido. They're a whole lot different from men in that department. Could end up with a larger hoohoo. lol.
    ~ PLEASE DO NOT ASK FOR SOURCE CHECKS ~

    "It's human nature in a 'more is better' society full of a younger generation that expects instant gratification, then complain when they don't get it. The problem will get far worse before it gets better". ~ kelkel

  28. #28
    Brazensol's Avatar
    Brazensol is offline Productive Member~ Recognized Member Winner - $100
    Join Date
    Jun 2012
    Posts
    1,496
    Quote Originally Posted by austinite View Post
    Well, women would have the same effects as men as far as increased NO levels, lower BP, better blood flow, etc... but it won't do anything really for a females libido. They're a whole lot different from men in that department. Could end up with a larger hoohoo. lol.
    It was the better NO levels and blood flow I was thinking of. On the other hand my wife already has a very low heart rate (in the 50's). I wonder how it would effect that?

  29. #29
    austinite's Avatar
    austinite is offline HRT Specialist ~ AR-Platinum Elite-Hall of Famer ~
    Join Date
    Mar 2012
    Location
    Cialis, Texas
    Posts
    31,169
    I wouldn't bother with Cialis for her. Just use L-Arginine. It will increase nitric oxide levels, increase vessel circumference and make for better blood flow.
    ~ PLEASE DO NOT ASK FOR SOURCE CHECKS ~

    "It's human nature in a 'more is better' society full of a younger generation that expects instant gratification, then complain when they don't get it. The problem will get far worse before it gets better". ~ kelkel

  30. #30
    Rusty11's Avatar
    Rusty11 is offline Senior Member
    Join Date
    Aug 2012
    Location
    CA
    Posts
    1,704
    Great post, austinite. I think the cialis thread causes many to jump right in with 10 mg/day. Like you stated, it's best to start low and work your way up over the course of a couple of months. I started low, gradually up to 10mg then realized that 6mg was good enough-along with arg/cit. I suffer from severe allergies and bad headaches. But I suffer from none of the bad sides you listed

    Edit: regarding the prostate, I pee like a race horse and don't have to get up 2/3X per night. It's a beautiful thing.
    Last edited by Rusty11; 08-25-2013 at 06:08 PM.
    austinite likes this.

  31. #31
    austinite's Avatar
    austinite is offline HRT Specialist ~ AR-Platinum Elite-Hall of Famer ~
    Join Date
    Mar 2012
    Location
    Cialis, Texas
    Posts
    31,169
    Quote Originally Posted by Rusty11 View Post
    Great post, austinite. I think the cialis thread causes many to jump right in with 10 mg/day. Like you stated, it's best to start low and work your way up over the course of a couple of months. I started low, gradually up to 10mg then realized that 6mg was good enough-along with arg/cit. I suffer from severe allergies and bad headaches. But I suffer from none of the bad sides you listed

    Edit: regarding the prostate, I pee like a race horse and don't have to get up 2/3X per night. It's a beautiful thing.
    Good point, Rusty. Wholeheartedly agree!
    ~ PLEASE DO NOT ASK FOR SOURCE CHECKS ~

    "It's human nature in a 'more is better' society full of a younger generation that expects instant gratification, then complain when they don't get it. The problem will get far worse before it gets better". ~ kelkel

  32. #32
    Trevtrev's Avatar
    Trevtrev is offline Associate Member
    Join Date
    Jun 2013
    Posts
    435
    Has anyone had any trouble jumping right in with 10mg?

    Today was my first day, started with 5mg this morning, but the temptation is there to jump up to ten and see what happens. I'm 43yo if that matters.

    So far so good...

  33. #33
    AnabolicBoy1981 is offline Anabolic Member
    Join Date
    Mar 2004
    Location
    Pennslyvania
    Posts
    2,449
    So helps boners, increases insulin sensitivity, and increases pump. Yay. I just got some indian stuff. Its 20 mgs. Is that too much? I think the highest dose is 40 right?

  34. #34
    austinite's Avatar
    austinite is offline HRT Specialist ~ AR-Platinum Elite-Hall of Famer ~
    Join Date
    Mar 2012
    Location
    Cialis, Texas
    Posts
    31,169
    Quote Originally Posted by AnabolicBoy1981 View Post
    So helps boners, increases insulin sensitivity, and increases pump. Yay. I just got some indian stuff. Its 20 mgs. Is that too much? I think the highest dose is 40 right?
    20 is a pretty aggressive dose. Once it compounds in your system, low doses should suffice. I've never needed more than the 10mg I take daily.
    ~ PLEASE DO NOT ASK FOR SOURCE CHECKS ~

    "It's human nature in a 'more is better' society full of a younger generation that expects instant gratification, then complain when they don't get it. The problem will get far worse before it gets better". ~ kelkel

  35. #35
    Rusty11's Avatar
    Rusty11 is offline Senior Member
    Join Date
    Aug 2012
    Location
    CA
    Posts
    1,704
    Quote Originally Posted by Trevtrev View Post
    Has anyone had any trouble jumping right in with 10mg?

    Today was my first day, started with 5mg this morning, but the temptation is there to jump up to ten and see what happens. I'm 43yo if that matters.

    So far so good...
    Many have. Take 5mg this evening. If you get sides you don't like, they'll ease up.Bet you wake up tomorrow with a nice surprise waiting...

  36. #36
    crazy mike is offline Banned for repping Dangerous Substances
    Join Date
    Dec 2012
    Location
    Micanopy/Gainesville, Fl
    Posts
    5,868
    Quote Originally Posted by Rusty11 View Post
    Many have. Take 5mg this evening. If you get sides you don't like, they'll ease up.Bet you wake up tomorrow with a nice surprise waiting...
    My doctor prescribed my Cialis and told me to jump up to 10mg anytime. Of course we can always drop back. I'm on 10mg and it's great. Better woods wow. ...crazy mike

  37. #37
    Rusty11's Avatar
    Rusty11 is offline Senior Member
    Join Date
    Aug 2012
    Location
    CA
    Posts
    1,704
    Mike, don't want to get personal, but how did you get your dr. to prescribe it?

  38. #38
    crazy mike is offline Banned for repping Dangerous Substances
    Join Date
    Dec 2012
    Location
    Micanopy/Gainesville, Fl
    Posts
    5,868
    Quote Originally Posted by Rusty11 View Post
    Mike, don't want to get personal, but how did you get your dr. to prescribe it?
    Hey I'm much older ya know. So I told him I was having trouble holding it up and so he said what do you want Viagra or Cialis. He gave me a fee coupon for a month and said I could get a high dose or whatever if I like it.
    He is my internist (GP) and is going to check my prolactin now also. ...crazy mike

  39. #39
    Rusty11's Avatar
    Rusty11 is offline Senior Member
    Join Date
    Aug 2012
    Location
    CA
    Posts
    1,704
    Mike, you're not that much older than me-52in a few days. Wonder why my doc said it's only prescribed for prostate problems. Maybe he's misinformed. Oh well. Thanks for answering.

    Edit: sorry for de-railing the thread, austinite

  40. #40
    austinite's Avatar
    austinite is offline HRT Specialist ~ AR-Platinum Elite-Hall of Famer ~
    Join Date
    Mar 2012
    Location
    Cialis, Texas
    Posts
    31,169
    Quote Originally Posted by Rusty11 View Post
    Mike, you're not that much older than me-52in a few days. Wonder why my doc said it's only prescribed for prostate problems. Maybe he's misinformed. Oh well. Thanks for answering.

    Edit: sorry for de-railing the thread, austinite
    Not at all man. Good conversation there. If it's Cialis related, it belongs here
    ~ PLEASE DO NOT ASK FOR SOURCE CHECKS ~

    "It's human nature in a 'more is better' society full of a younger generation that expects instant gratification, then complain when they don't get it. The problem will get far worse before it gets better". ~ kelkel

Page 1 of 4 1234 LastLast

Thread Information

Users Browsing this Thread

There are currently 1 users browsing this thread. (0 members and 1 guests)

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •