VIOXXX off the market

**chicamahomico** · 10-02-2004, 10:57 AM

http://www.cnn.com/2004/HEALTH/09/30...ithdrawn.reut/

**DoctaBig** · 10-02-2004, 11:08 AM

yah we got the call a few days ago. 3X greater risk of cardiovascular events, ouch. That was merck second best selling drug at 3 billion a year, Zocor makes 5 billion. I suggest buying Pfizer stock. they own both of the other drugs bextra and celebrex. You'll see another cox-2 on the market soon for sure. I bet the pfizer guys through a huge kegger though.

**symatech** · 10-02-2004, 12:36 PM

celebrex is a cox 2. i think monsanto developed it correct?

**anabolic_king** · 10-02-2004, 01:24 PM

hmmm

**decadbal** · 10-02-2004, 01:26 PM

i know nothing bout this sub..sup whores

**DoctaBig** · 10-02-2004, 02:31 PM

Originally Posted by symatech

celebrex is a cox 2. i think monsanto developed it correct?

yep its a cox 2, as is bextra. I dont know who exactly developed it though??

pop quiz.....

what is the only cox 3 inhibitor??????

**Dude-Man** · 10-02-2004, 02:34 PM

my favorite is mobic.

**cb25** · 10-02-2004, 02:52 PM

Originally Posted by DoctaBig

pop quiz.....

what is the only cox 3 inhibitor??????

acetominophen?

**chicamahomico** · 10-02-2004, 02:58 PM

It's too bad, I had excellent results with the stuff the few times I used it but I near sh*t myself the first time I got a few sample packs and read the insert.

**DoctaBig** · 10-02-2004, 03:07 PM

Originally Posted by cb25

acetaminophen?

nice work....

man, some people on here really know their stuff....I'm impressed

that is assuming you didn't just go look it up

**symatech** · 10-02-2004, 03:08 PM

Originally Posted by chicamahomico

It's too bad, I had excellent results with the stuff the few times I used it but I near sh*t myself the first time I got a few sample packs and read the insert.

whats the insert say?

acetaminophen is cox 3 yes

**chicamahomico** · 10-02-2004, 03:23 PM

It was a couple years back so I don't remember exactly I just remember thinking holy crap after reading it. Maybe one of the docs or pharms on here can give us a personal opinion or share some patient experiences with the stuff.

Originally Posted by symatech

whats the insert say?

acetaminophen is cox 3 yes

**Dude-Man** · 10-02-2004, 03:29 PM

isn't phenacetin also a cox-3 inhibitor? granted, it's a suspected carcinogen.. but hey.

**DoctaBig** · 10-02-2004, 04:05 PM

Originally Posted by chicamahomico

It was a couple years back so I don't remember exactly I just remember thinking holy crap after reading it. Maybe one of the docs or pharms on here can give us a personal opinion or share some patient experiences with the stuff.

All the patients i've seen taking vioxx seemed to tolerate it quite well. Those package/patient inserts are required by law to list any and all side effects and adverse drug reactions, even if they are completely unrelated to the drug itself. With that said there is always a pearl hidden in those inserts. The medical community has suspected for quite awhile now that vioxx caused adverse cardiac effects; however, it was unknown how bad it really was until the results of this new colon polyp study were published. From a pharmacist's perspective it amazes me that prescribers even use these drugs to the extent they do. Most patients do not recieve the necessary level of pain control with these medications (even at maximal doses). Therefore they are forced to utilize NSAIDs or APAP therapy to gain full pain control. So, why pay $150-$200 per month for a medication that doesn't work, when a patient could just use NSAID therapy for $5.00 per month and have better pain control??? Disclaimer!!!!! These drugs do have their place in patient whom either have or are at risk for stomach ulcers. In this case, by all means please use a selective cox-2.