09-23-2004, 08:33 PM #1
Please Comment on my Steroid Write-up on Deca Durabolin!
The decanoate ester of nandrolone is generally referred to as Deca , stemming from the brand name Deca-Durabolin under which nandrolone was marketed by the Organon Company. The Pharmaceutical name Nandrolone/Nor-testosterone (as undecanoate) has a chemical structure "19-Nor-4-androstene-3-one,17b-ol" or "4-Estren-17beta-ol-3-one." The molecular weight of the base is 274.4022 and the molecular weight of the ester is 172.2668 with Decanoic acid containing 10 carbons. But as the reference list up above suggests there are many generic forms of this compound available. Nandrolone is perhaps the best marketed and easy to get steroid out there and it has always enjoyed an immense popularity. Its fairly accurate to state that Deca is by far the most used steroid. The deca/d-bol stack, it is often suggested, is where the practice of stacking comes from. But what does it owe its popularity too? Well, nandrolone has some unique qualities that make it unlike any other steroid known to man.
Nandrolone is more commonly known as the base steroid 19Nor-testosterone. As this structure would indicate, itís like testosterone in appearance but for one small change: the absence of a carbon atom in the 19th position. This gives it a number of very distinct features. First of all it makes nandrolone a notably weaker agonist of the androgen receptor. That alone causes quite a reduction in the risk of androgenic side-effects. This is because it is the only steroid that is affected by the 5-alpha-reductase (5AR) enzyme in a way that makes it even less androgenic. Unlike testosterone which forms DHT (dihydrotestosterone) at the 5AR enzyme, a hormone 3-4 times as potent as an androgen receptor stimulator, nandrolone forms DHN (dihydronandrolone) a hormone that is even less suited than the already mild parent hormone for agonizing the androgen receptor. Those two features combined make nandrolone a very safe bet for people at risk for prostate hypertrophy, acne and aggravated male pattern hair loss. At the same time its estimated that nandrolone is 2.4 times as anabolic as testosterone1, on a gram for gram basis.
Due to the many different ways that testosterone mediates anabolism, one has to take that statement with a serious grain of salt, but it does establish nandrolone as a potent muscle builder and performance enhancer with a comparatively safe character, at least androgenically speaking. This androgenic mildness is perhaps the greatest reason for its popularity. But due to the lack of immediate anabolic activity nandrolone is rarely used alone. Its the most known and sought after product for use as a base steroid, to use in conjunction with a more androgenic specimen to enhance the results without increasing androgenic side-effects to a serious degree.
The ways in which nandrolone exerts its anabolic effects are two-fold. First of all it's a good mediator for nitrogen retention. When nitrogen retention is high, in essence it means that the cells are taking up more nitrogen than they are releasing. Why is this a good thing though? Well every amino acid has what is known as an amino-group, which contains nitrogen. When nitrogen is retained it means there is a high concentration of amino acids in a cell, which in turn positively affects the rate of protein synthesis. Since every tissue in the body is made from protein, including muscle, this means that muscle hypertrophy is facilitated. A second factor is through estrogen. While nandrolone's rate of aromatization is considerably smaller than that of testosterone, it does convert to a particularly powerful form of estrogenĻ. This has been noted to increase glycogen storage, growth hormone release and upgrade the androgen receptor in some tissues. In this case it also entails agonizing of aldosterone, but more on that later.
On an interesting note, the 5-alpha-reduced versions enlighten us as to the anabolic effect of nandrolone as opposed to that of testosterone. Since nandrolone is weakened at the 5AR enzyme and testosterone becomes notably stronger at the 5AR enzyme it makes sense that testosterone would be a better anabolic mediator in tissues with a high concentration of this enzyme, and that nandrolone would be the stronger of the two in tissues with a lower count of 5AR enzyme1b. Because 5AR is not as well represented in muscle tissue it accounts for the finding that nandrolone is 2.4 times more anabolic when it comes directly to muscular hypertrophy. It also explains why its less of a risk for androgenic side-effects such as benign prostate hypertrophy (BPH) and androgenetic alopecia (MPB). Both the prostate and the scalp namely have high concentrations of the 5AR enzyme.
If indeed the overall yield of estrogen is so much smaller, and so is the rate of androgen receptor stimulation, how then is nandrolone so anabolic? The common belief is through a third receptor: the progesterone receptor. It has been concluded that both nandrolone and several of its metabolites 3, 4 do indeed activate the progesterone receptor and are altered by it. On the one hand progestagenic activity decreases the estrogen receptor concentration in some tissues; it also mediates estrogenic action in other tissues. So while estrogenic side-effects are fairly uncommon with nandrolone use alone, they can indeed occur and the implications of nandrolone's activity as a progesterone indicate these potential side-effects aren't to be solved with an aromatase inhibitor alone (likeArimidex). As long as there is estrogen in the system (indicating a possible increase of the problem when stacked with another aromatizing compound) progesterone can agonize its effects. And since progesterone receptors are found in breast tissue and have been linked to the formation of milk ducts, progestagenic activity may aggravate possibly gynocomastia. So while such problems are rare, when they occur they aren't easily treated.
For those of you looking to use nandrolone as your only steroid, be aware that the gains on nandrolone are not only mild, but also quite hard to maintain even with a dosage of 200-800mg/wk. Nandrolone, in the first place due to its combined estrogenic/progestagenic properties, is quite suppressive of the natural testosterone production. Since it actively participates at three receptors itís very quick and merciless when it comes to giving negative feedback to the release of gonadotropin releasing hormone from the hypothalamus. But then one also has to take into account its affinity for esterases, making it stay active in the body significantly longer than most hormones. Because that means upon cessation of nandrolone-use you'll still be under quite suppressive conditions, there simply isn't enough intrinsic anabolism available to support the mass you gained, resulting in a rather quick and inglorious reduction of weight.
A benefit of nandrolone use often reported is the pain-free workouts because nandrolone lubricates the joints. It stores a lot of water (as synovial fluid) in the joints, which eases the impact of the heavy weights handled by bodybuilders and weight lifters. One may wonder how nandrolone can do a better job at it than a steroid that aromatizes much stronger such as a testosterone ester, but itís quite easily explained. One study at least goes to show that nandrolone metabolites are also aldosterone agonists6. Although we aren't entirely sure of the mechanism by which this occurs. But, while sparing you the details of this complex hormone, aldosterone has a strong function in the retention of sodium in the body. High sodium levels correlate with a high storage of water and that would explain the aforementioned effect. Of course one needs to note the implication of this of course: a bulkier frame and a certain loss of definition are not uncommon with nandrolone, perhaps more so than with testosterone.
Although the side effects with Deca are relatively low with dosages of 400 mg/week, androgenic-caused side effects can occur. Most problems manifest themselves in high blood pressure and a pro-longed time for blood clotting, which can cause frequent nasal bleed-ing and prolonged bleeding of cuts, as well as increased production of the sebaceous gland and occasional acne. Some athletes also re-port headaches and sexual overstimulation. When very high dos-ages are taken over a prolonged period, spermatogenesis can be inhibited in men, i.e. the testes produce less testosterone. The reason is that Deca-Durabolin, like almost all steroids , inhibits the release of gonadotropins from the hypophysis.
Women with a dosage of up to 100 mg/week usually experience no major problems with Deca. At higher dosages androgenic-caused virilization symptoms can occur, including deep voice (irreversible), increased growth of body hair, acne, increased libido, and possibly clitorihypertrophy. Women, who experience disturbance even at a weekly dose of only 50 mg/week of Deca-Durabolin, are often better off taking the earlier-mentioned and faster-acting Durabolin. Unlike the long-acting Deca, when Durabolin is administered once or twice weekly in a dosage of 50 mg, no concentration of undesired amounts of androgens occur. Since most female athletes get on well with Deca-Durabolin a dose of Deca 50 mg +/week is usually com-bined with Oxandrolone 10 mg +/day Both compounds, when taken in a low dosage, are only slightly androgenic so that masculinizing side effects only rarely occur. Deca, through its increased protein synthesis, also leads to a net muscle gain and Oxandrolone, based on the increased phosphocreatine synthesis, leads to a measurable strength gain with very low water retention. Other variations of administration used by female athletes are Deca and Winstrol tab-lets, as well as Deca and Primobolan S-tablets.
It makes sense then that those particularly prone to the effects and side-effects of estrogen would take extra precaution. Blocking aromatase, considering the previous paragraph, would be a poor choice, but competitively inhibiting the estrogen receptor itself with anastrozole (Arimidex ) or tamoxifen citrate (Nolvadex ) might bring some relief since a large portion of progestagenic action is nullified if there is no circulating estrogen around, or if it is kept from being activated by the estrogen receptor. Slightly higher doses, or the use of an aromatase inhibitor like arimidex can be stacked if nandrolone is used in conjunction with another aromatizing steroid. It has also been noted that the steroid stanozolol (Winstrol) may provide relief as it too binds to the progesterone receptor but remains unaltered by it. How strong of a competitor it is in such a case and what sort of doses would be needed are as much your guess as they are mine, so this may be non-issue. But it does bode well for the stacking of nandrolone with stanozolol in that you have nothing to lose and everything to gain.
Nandrolone stacks well with virtually anything. Due to its mildly aromatizing and its progestagenic activity itís mostly used as a mass building compound by all but the monstrously huge. Because some water retention is a fact, one would not desire to include it in a cutting phase, especially if its one of your first cycles. Nandrolone is used in doses of 200-600 mg per week. 400 mg is the common recommendation for a somewhat experienced user, when used in conjunction with another product. Nandrolone as decanoate, as found in deca-durabolin, is a long acting ester of 10 carbons. That means 1 injection weekly will more than suffice as it has quite a long span of activity.
To this effect itís preferably stacked with another aromatizing compound such as a long acting testosterone like cypionate , enanthate or sustanon 250. For a beginner cycle, we want to note that the testosterone compound is the most active compound and itís therefore more desirable to lower the dose of nandrolone rather than the dose of testosterone. Often beginners look to start at 400 mg of nandrolone and 250 mg of testosterone. A better suggestion would be 200 mg of nandrolone and 500 mg of testosterone. Then bump the nandrolone to 400 mg.
It also makes a good match for doses of Anadrol or Dianabol , although neither compound can be used for the time-span of nandrolone decanoate due to liver toxicity. This isn't the case for a long-acting testosterone ester. Often nandrolone and test are stacked in conjunction with Anadrol or Dianabol for the first few weeks of a stack to boost gains and strength. Most athletes usually take 15-40 mg Dianabol/day and 200-400 mg Deca/week.
A nandrolone stack accompanied by stanazolol (Winstrol/Stromba) makes sense as well, especially for those who are highly prone to gyno. It's commonly accepted that stanazolol can compete for the progesterone receptor, and since nandrolone can act as a progestin, this is a wise precaution. Progesterone agonizes estrogen and while nandrolone only aromatizes slightly and cases of gyno with moderate nandrolone use is rare, when stacking it with another aromatizable compound like Dianabol or testosterone, you may not want to take the chance.
More advanced users often consider the use of low-dose nandrolone (200 mg/week) with cutting cycles as well, which goes to prove that nandrolone really does stack with anything. One good one is running Deca along with Equipose as 62% of Anabolic review members stated in a poll. One Anabolic review member claimed ďThe deca helped make great strength gains/joint comfort, and the equipose made me eat like a horse and brought out my vascularity. Another AR member claims ďI have run a Eq and Deca stack together, all I can say unreal, I loved it. Gains where awesome, but the feeling you get from week 6 and on, you feel superhuman 24/7, I have felt pumps before but nothing like on a Eq/Deca stack, heres what I did....
weeks 1-12 EQ 300mg/wk
weeks 1-12 Deca 300mg/wk
weeks 1-15 Test Enthanate 600mg/wk
weeks 12-18 Anavar 30mg/day
This is a must try, I will be doing something similair(EQ+Deca) many more times!
Using an estrogen-receptor antagonist, while not fool-proof obviously, may serve some benefit. Agonized or not, without binding to the receptor estrogen loses most of its influence. Using stanazolol and either Arimidex (.25mg/day) or Nolvadex (10mg/day) during a stack with nandrolone is usually the best prescription. Post-cycle use of Clomid and Nolvadex are used to help HPTA recover faster and retain gains also comes highly recommended, and preferably for longer than you would with most stacks, since nandrolone stays active for a very long time.
Nandrolone with a decanoate ester is fairly long acting (10 carbons) to begin with and if on top of that a lot of the drug can be de- and re-esterified that means the substance stays active in the body for quite a long time. This has resulted in positive drug tests for the hormone nandrolone and many of its metabolites, most notably 19-Norandrosterone up to 18 months after last use of the drug. While this is a fairly known fact, the recent number of athletes (including well known soccer stars) that have tested positive for nandrolone would indicate a lot of misinformation or plain lack of information in some circles. Positive tests, with reprimands, that could have easily been avoided. So anyone subject to any form of athletic drug test should refrain from using 19-Nortestosterone (nandrolone) or any of its metabolites, that includes nor-prohormones.
One last note that is of critical relevance to drug tested athletes is the interaction between nandrolone and esterase. Injectable, non 17-alpha-alkylated hormones are often esterified. This means attaching an ester to a specific position on the steroid causing it to be more lipophyllic. That means it stores well in body-fat and is only slowly released into the bloodstream, giving the whole a time-released character. The more carbons an ester has the longer it will last. For the drug to become active it needs to remove its ester. When released into the bloodstream simply the suspension in H2O will solve that. But in the body-fat the ester can also be removed by the enzyme esterase. But esterase works two ways, meaning in some cases it can also attach an ester. Nandrolone is such a case.
The availability of Deca is dropping, but its still the most counterfeited steroid in the world. That makes it more likely that an inexperienced buyer will get scammed looking for nandrolone decanoate, than looking for boldenone undecylenate.
Brands & Products:
Organon Deca-Durabolin (GB, GR, Fl, Canada, U.S.) 100 mg/ml
Deca-Durabolin (G, B, CH, DK, ES, FR, GB,U.S, GR, ML, PL,FI; Mexico, Thailand,YU, U.S., A, South Africa) 50 mg/ml
Deca-Durabol (S) 25, 50 and 100 mg/ml
Deca-Durabolin '100' (NL) 100 mg/ml
Adelco Anaboline (GR) 50 mg/ml
Keene Androlone-D 200 (o.c.) (US) 200 mg/ml
Bender Deca-Durabolin (A) 25 mg/ml
Donmed Deca-Durabolin (S-Africa) 25 mg/ml
Hermes/Organon Deca-Durabolin (YU) 25 mg/ml
Steris Deca-Durabolin (US) 200 mg/ml
Nandrolone Dec. (US) 50, 100 and 200 mg/ml
Chemica Elpihormo (GR) 50 mg/ml
Genapharm Extraboline (GR) 50 mg/ml
Jenapharm Turinabol Depot (o.c.) (G) 50 mg/ml
Turinabol Depot (BG, CZ) 50 mg/ml
Hyrex Hybolin Decanoate (US) 50 mg/ml and 100 mg/ml
Etem Jebolan (TK) 50 mg/ml
Lyphomed/Quad Nandrol. Dec. (o.c.) (US) 100 mg/ml
Forest Nandrobolic LA (o.c.) (US) 100 mg/ml
Hauck Neo-Durabolic (o.c.) (US) 100 and 200 mg/ml
Rafarm Nurezan (GR) 50 mg/ml
Gedeon Richter Retabolil (U, HU, BG) 25 and 50 mg/ml
Medexport Retabolin (Russia) 50 mg/ml
Orion Sterobolin (o.c.) (FL) 50 mg/ml
Demo Ziremilon (GR) 50 mg/ml
Bela-Pharm Veterinary: Anabolicum (G) 25 mg/ml; 10 ml/50 ml
Ttokkyo Labs Nandrolone 300 mg/ml
Brovel Norandren 50 (Mexico) 50 mg/ml; 10 ml/50 mI
Profile by Big Cat and Anabolicreview.com
Picture by PTbyJason
09-23-2004, 09:16 PM #2
You forgot to take Big Cats name of the bottom of the article.
That article is very good if you wanted to you could go into detail about collagen synthesis and prolactin.
09-23-2004, 09:22 PM #3
Nice, but I agree with Anhydro. The collagen sythisis aspect is very important.
09-23-2004, 09:24 PM #4
any ideas as to where i could get some research info on that?
09-23-2004, 09:28 PM #5
Nandrolone is proven to be a progestin. This fact is of clear importance in bodybuilding, because while moderate Deca -only use actually lowers estrogen levels as a consequence of reducing natural testosterone levels and thus allowing the aromatase enzyme less substrate to work with, Deca nonetheless can cause gyno in some individuals. Furthermore, just as progesterone will to a point increase sex drive in women, and then often decrease it as levels get too high, high levels of progestogenic steroids can kill sex drive in male bodybuilders, though there is a great deal of individual variability as to what is too much.
Progestogenic activity also inhibits LH production, and contrary to common belief, even small amounts of Deca are quite inhibitory, approximately as much so as the same amount of testosterone .
To some extent, nandrolone aromatizes to estrogen, and it does not appear that this can be entirely blocked by use of aromatase inhibitors Ė indeed, aromatase may not be involved at all in this process (there is no evidence in humans that such occurs) with the enzyme CYP 2C11 being in my opinion the more likely candidate for this activity.
09-23-2004, 09:29 PM #6
I dont know who wrote this article, I have another one about stanzolol
While injecting test increases protein syntesis by roughly 50 times, depending on dose and time, most bodybuilders forget that it will reduce collagen synthesis by more than 50% -- more like 80%, giving you the collagen synthesis rate of a senior citizen. Since collagen makes up tendons, bros are very prone to injury if they continue to lift very heavy, unless they cycle off T and let their collagen synthesis get back to normal. It's like having the skeletal muscle of a gorilla with the tendons of a very old man.
Winstrol increases collagen synthesis. It will give you bigger tendons. However, your body compensates for this by making them more brittle, weaker, and more prone to injury. I can't tell you how many bros work out anaerobically and become injured while on winstrol. Guys who lift in the 1-5 rep range while on winstrol, to baseball players who sprint all out from a stationary position -- winstrol should be the LAST drug they choose. Most of them like winstrol because they don't get the weight gain from it but it is very detrimental to bros who train for any sport anaerobically. Tendons tear easily on it.
Also, the drugs I mention increase collagen syn while also increasing collagen cross-linking integrity, making for a much stronger tendon.
Winstrol, on the other hand, will dramatically increase collagen syn, but ironically it decreases collagen cross-linking integrity, thus making a much weaker tendon.
You can plan a cycle of AAS which will increase collagen synthesis and skeletal muscle growth at the same time. The key is the drug(s) you choose.
Deca , Equipoise , Anavar , and Primobolan will ALL increase skeletal muscle while at the same time dramatically increase collagen syn and bone mass and density, leaving you with a substantially reduced chance of becoming injured than if you choose to use AAS like sus, cyp, or enth.
While testosterone will increase bone mass and density, even at supra-physiological levels, the result is weaker tendons due to inhibition of collagen syn.
To plan a cycle where the goal is to increase skeletal muscle mass/strength while at the same time increase joint/tendon/ligament strength, enough to keep up with the dramatic increase in skeletal muscle, you must choose drugs like Eq, Deca, Anavar, or Primo as the base of your cycle. Testosterone and its esters can be added to your cycle to keep levels within a 'normal' physiological range (ie, 100-200 mg/wk) but must not go above this. Since drugs like eq, deca, anavar and primo will reduce endogenous, natural levels of test, these levels may be maintained with exogenous test in the 100-200 mg/wk range. Test at this dose will not inhibit collagen syn, but paradoxically, will help increase it. It is when exogenous testosterone is used > 200 mg/wk that collagen syn is inhibited.
Deca @ 3 mg/kg a week(about 270 mg/wk for a 200 lb male) will increase procollagen III levels by 270% by week 2. Procollagen III is a primary indicator used to determine the rate of collagen syn. As you can see, deca is a very good drug at giving you everything you want -- an increase in collagen syn, an increase in skeletal muscle, and increases in bone mass and density. The one thing it does not give you is wood
Primobolan, @ 5 mg/kg, will increase collagen synthesis by roughly 180% -- less than deca and equipoise but still substantial.
Equipoise @ 3 mg/kg will increase procollagen III by approximately 340% -- slightly better than deca.
Oxandrolone has over a hundred studies documenting its effectiveness at treating patients needing rapid increases in collagen syn to enhance healing.
These drugs have longer half-lives than most other AAS, so this should be considered when timing your post cycle clomid use. Here they are:
Deca: 15 days Equipoise: 14 days Primobolan: 10.5 days
Anavar has a half-life of only 8 hours so it should not pose a problem.
GH is probably the most remarkable drug at increasing collagen synthesis. It increases collagen syn in a dose dependant manner -- the more you use, the more you will increase collagen syn. It has also demonstrated this ability in short and long term studies. From what I've read, hGH at 6 iu/day increased the collagen deposition rate by around 250% in damaged collagen structures. This result indicates that the increased biomechanical strength of wounds to collagen structures treated with biosynthetic human growth hormone was produced by an increased deposition of collagen in the collagen structures.
Eq, primo, anavar, and deca are all good -- they increase several biomakers of collagen syn -- ie, type III, II, I, procollagen markers. GH just seems to do so most dramatically.
Use of any of these drugs @ supra-physiological levels with a maintenance dose of test will increase collagen syn while at the same time increase skeletal muscle mass. Skeletal muscle mass gains will not be as dramatic as with large testosterone doses but you have to weigh the risk/reward basis for yourself. Also, these drugs do not satisfy the libido like testosterone, but that is not the point of this thread. It is only to demonstrate that you can increase skeletal muscle and collagen syn at the same time with certain AAS -- the decision is up to you.....
09-23-2004, 09:30 PM #7Owner
- Join Date
- Mar 2002
A lot of that is word for word from big cat. These must be writen in your own words and no part can be copied.
09-23-2004, 09:31 PM #8
Here is one on Deca and bone density
Nandrolone Decanoate (Deca Durabolin ) and Bone Density
A number of studies show that anabolic steroids can increase bone density.
The studies below showed that nandrolone decanoate does.
Nandrolone decanoate for men with osteoporosis.Hamdy RC, Moore SW, Whalen KE,
Landy C.Am J Ther. 1998 Mar;5(2):89-95.
To compare the efficacy and safety of nandrolone decanoate
and calcium (NDC) with those of calcium alone (CAL) in men with
idiopathic osteoporosis, a 12-month, randomized, prospective, controlled
study, was performed in an outpatient clinic. Twenty-one men with idiopathic
osteoporosis (as determined by radiological and dual energy x-ray
absorptiometry findings) were randomly allocated to either 50 mg nandrolone
decanoate intramuscularly (im) weekly and 1,000 mg oral calcium carbonate
daily (NDC group) or to 1,000 mg oral calcium carbonate daily (CAL group).
Bone densitometry (total body, left femur, and lumbar spine), serum, and
urine biochemical parameters were measured at 3-month intervals. In the NDC
group, bone mineral density initially increased, reached a plateau, and then
decreased to near baseline levels at 12 months. Increases in lean muscle mass
mirrored these changes. Free and total testosterone significantly decreased.
Hemoglobin increased in all patients in this group. Patients in the CAL group
exhibited no significant change in either total body or bone mineral density
or biochemical parameters. Thus, nandrolone decanoate, 50 mg im weekly,
transiently increases the bone mass of men with idiopathic osteoporosis in
this preliminary study. Careful monitoring is necessary.
Effects of nandrolone decanoate on bone mass in established osteoporosis.
Passeri M, Pedrazzoni M, Pioli G, Butturini L, Ruys AH, Cortenraad MG.
Maturitas. 1993 Nov;17(3):211-9.
A double-blind, randomized, placebo-controlled study was conducted in 46
postmenopausal women with established osteoporosis in order to assess the
long-term effects of nandrolone decanoate on the bone mineral density (BMD)
of the lumbar vertebrae and of the distal third of the radius and on the
biochemical markers of bone turnover. The patients received intramuscular
injections of placebo or 50 mg nandrolone decanoate every 3 weeks for 18
months. Thirty-two of the initial 46 patients completed 1 year of study and
25 completed the whole study period of 18 months. Overall, vertebral BMD
increased by 2.9% in the nandrolone decanoate group and fell by 2.3% in the
placebo group. Radial BMD showed a slight but transient improvement, with a
subsequent return to basal levels in the nandrolone decanoate group, whereas
there was a progressive decrease in the placebo group. Patients treated with
nandrolone decanoate also complained less of bone pain. Urinary
hydroxyproline decreased significantly in treated patients, whereas
osteocalcin tended to increase, but the change was not significant. HDL
cholesterol concentrations decreased only slightly and haemoglobin increased
significantly in the nandrolone decanoate group. Two patients treated with
nandrolone decanoate withdrew from the study because of hirsutism and
hoarseness. The results indicate that nandrolone decanoate exerts positive
effects on vertebral BMD and on bone pain in patients with established
Effects of nandrolone decanoate therapy on bone mass and calcium metabolism
in women with established post-menopausal osteoporosis: a double-blind
placebo-controlled study.Gennari C, AgnusDei D, Gonnelli S, Nardi P.Maturitas.
In many patients with involutional osteoporosis anabolic steroids may
produce a rapid subjective improvement and a pronounced reduction in the
frequency of complaints. Animal experiments have demonstrated that anabolic
steroids can also have an objective effect on bone tissue. Twenty (20) post-
menopausal osteoporotic patients were randomly assigned to 2 different treatment
regimens; 10 patients were treated with 50 mg i.m. of nandrolone decanoate
(ND) every 3 wk for 12 mth and 10 patients were treated with a placebo. Both
groups also received an oral calcium supplement (1 g/day). Bone mineral
content (BMC) was measured by dual photon absorptiometry before and after 1,
3, 6 and 12 mth of treatment. Plasma alkaline phosphatase (ALP) and urinary
hydroxyproline excretion were measured at the same time. Intestinal calcium
absorption was measured by the 47Ca oral test before and after treatment. A
transiliac bone biopsy was performed before and after treatment in 4 patients
in each group. After 1 yr there was a significant increase in lumbar spine
BMC in the group receiving calcium plus ND. A progressive increase in plasma
ALP was also observed in the group treated with ND but this was not
significant, whereas radiocalcium absorption did increase significantly in
this group. Histomorphometric study of bone samples demonstrated a
significant increase in trabecular bone volume (TBV) and in active osteoid
surface area in the patients treated with ND. Because plasma ALP tends to
increase when a small decrease in bone resorption occurs (as measured by
urinary hydroxyproline excretion) and the active osteoid surfaces also
significant augment, we concluded that ND therapy increases the bone
formation rate through inhibition of bone resorption. This interpretation
could explain the considerable increase in lumbar spine BMC and the
significant increase in TBV observed in patients treated with ND.
09-23-2004, 09:32 PM #9
Deca and You by Macro
A short reply to 2thick- on the anabolic board
In honor of Ranger-who knows well the potential evils of Deca
Nandrolone , popularly known as Deca, is a classified as a progestin. Deca derives many of its benefits from its progestenic nature: including, but not limited to, increase IM fat storage and increased fluid retention in the joints from glucocorticoid(GC) stimulation.
Deca is the most widely used form of prescription contraception in the first world. Deca is superior to testosterone as a form of birth control because its progestenic effects which result in rapid onset of azoospermia. Progestins are used similarly in women, progestins given to women in birth control pills and other drugs such as norgestrel and norethidrone are classified as 19-nor-testosterone or 19 nor- progesterone derivatives. Natural progesterone plays an important role in sexual arousal- affecting GABA to a considerable extent. The addition of progestins like deca which compete with progesterone and decrease its production may result in drastically reduced sexual arousal. Interestingly enough, the chemical castration of sex offenders, is acheived through the use of a 19-nortestosterone derivative.
This brings us to the second most common problem with the use of progestenic drugs like Deca, the breast tissue has both PR(progesterone receptors) and ER(estrogen receptors) and stimulation of either will result in new tissue formation and growth. This will vary considerably from individual to individuals based on the numbers and ratio of receptors in the tissue. Some individuals have more PR, which will make them more susceptable to Gyno. Another suspected factor is that there are slightly physiologically different PR, as well as ER and AR, which may effect binding and expression of synthetic progestins either positively or negatively.
The use of Anti-estrogens and Aromatase-inhibitors will help by reducing stimulation of the ER in the breast tissue. However, those with high concentrations of PR or PR whose physiology allows for greater binding or expression of progestins will be faced with developing Gynomacastia.
1. DECA dick is real
2. DECA does cause Gyno
3. DECA is progestin it must be fought with anti-progestins
4. Use of Nolvadex and Arimidex will help, but only by reducing ER stimulation.
09-23-2004, 09:34 PM #10Owner
- Join Date
- Mar 2002
Great group of info you just posted
09-23-2004, 09:36 PM #11
ok i will do my best to type this up in my own words. This is more difficult than i thought.
09-23-2004, 09:37 PM #12
thanks anhydro that was awesome info!
09-23-2004, 09:42 PM #13Owner
- Join Date
- Mar 2002
Moush, It will be tough no doubt but you will learn a great deal from it and contribute to the future newbies to come. (don't that make you feel so good inside) ) I tried to do 10 to start and after two... my brain was fried. That is why I wanted you all to not take on more than two at a time.
09-23-2004, 09:48 PM #14Member
- Join Date
- May 2004
Ya you didnt pick an easy one bro, but looks like you have alot of info to work with. GL
09-23-2004, 09:56 PM #15
well atleast i kno there is a good reward at the end
09-23-2004, 09:58 PM #16Originally Posted by system admin
I would like to help your cause but work and school dont leave me much time. Sorry that i couldnt help though.
09-23-2004, 10:19 PM #17Owner
Originally Posted by Demon Deacon
- Join Date
- Mar 2002
09-24-2004, 06:33 AM #18
well i am in the process of re-writing the above research in my own words. Hopefully it will be an awesome paper! Thanks for the help guys
09-24-2004, 08:24 AM #19
I don't know if you have this in there, but to help out with the history part of this substance. Look into its use in HIV patents. From what I have heard it was originally designed for them and is still used on a regular basis to help out with body weight and immune system. It is something to look into. I don't have detailed facts but thats one thing you can add to the search.
09-24-2004, 08:54 AM #20Owner
Originally Posted by BigGenes
- Join Date
- Mar 2002
09-24-2004, 08:58 AM #21
Hey I know how bad I want help and if I can I am going to help out everyone else! This is only making our board better!
09-24-2004, 09:34 AM #22
thanks BG, i will try to get some info on that as well.
09-24-2004, 06:57 PM #23
hey system admin would you like me to start a new thread will the revised profile when i am done?
09-24-2004, 06:59 PM #24
Very informative bro...good stuff!
09-24-2004, 09:01 PM #25
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