07-24-2009, 03:59 PM #1
Anadrol 50 only cycle, a few serious questions.
Hopefully someone here knows what there talking about and can answer a few things.
Now there was this guy the other day that had a post about how he did about 3 or so cycles of only Anadrol 50. He said that he kept most of his gains, with no PCT. Now from what I know is that this steroid is very strong. Apparently he isn't that bright and didn't do any research. Now my questions is that why does TEST always have to be run with another steroid?
Assuming this guy isn't lying and everything is true.
07-24-2009, 04:12 PM #2
Mainly the reason you should always run test is so you dont risk sexual dysfunction.
07-24-2009, 05:29 PM #3Anabolic Member
- Join Date
- Jun 2005
07-24-2009, 05:39 PM #4
the guy is and has to be lieing or the stuff didnt work with him and he gained from working out harder and eating right ... i love anadrol ... it is very very harsh
i have dont two cycles of anadrol and sust... gained 30+ lbs from each cycle and lost 18 - 20 lbs after each cycle... kept the strength gains and some size but there are better (much better) combos that will yeild better gains and better long term results...
do some research and see why every one uses test and then adds on to that...
on top of all that what are you goals? stats? and cycle history?
if you have the anadrol and feel you must use it just be smart
07-24-2009, 06:26 PM #5
Im pretty sure I would never even use A50 with or without test to be perfectly honest. Its to powerful of a drug it seems for me. The main reason I was woundering about it was because I did a epistane cycle which is a Methylated version of the steroid Epitiostanol and I ran it without any sort of TEST. I had no sort of sexual dysfunction. In fact I had an erection all the time almost so to speak. Libido was way up. I did a pct of Nolvadex 40 40 20 20. With a solid 10lbs of dry mucsle gained. And didn't lose any muscle.
Im just a very paranoid person so I just want to make sure I don't screw myself up. I feel great. Going to tell my Dr what I did and going to get bloodwork done Aug 28.
It seems to me that everyone knows everything about all the gear except epistane. There doesn't seem really any detailed infromation on this steroid.
07-24-2009, 06:39 PM #6
- Join Date
- Dec 2008
- No source checks
- Blog Entries
Im sure this is also called havoc lol, maybe check that out..
07-24-2009, 06:44 PM #7
yeh Havoc is the brand name. I can't seem to find detailed information like from a medical dictionary.
07-24-2009, 06:50 PM #8
- Join Date
- Dec 2008
- No source checks
- Blog Entries
Other brand names:
Epistane , Havoc, Hemaguno
What is Epistane?
Epistane is one of the newest designer steroids on the market today, and it is gaining attention very quickly. Epistane is actually a methylated version of the controlled substance Epitiostanol (2±,3±-Epithio-5±-androstan-17²-ol), which was created in the 1960's and used as a treatment for breast cancer. Since the only place Epitiostanol is only availabe at this time is in japan, chemists added a methyl group to the compund and the final product was a substance now known as Epistane. Epistane is a sulfur containing steroid which is known to have strong and long lasting anti-estrogenic activity as well as weak androgenic and mytropic activities.
What you can expect?
Since it is designed to be anti-estrogenic you can expect very dry gains from this compound. Epistane has low androgenic to anabolic activity. This meaning that it is much more anabolic then androgenic. Thus making sides very minimal to non existant from this substance. Also one of the great properties of this substance is that it does a great job in keeping the natural suppression of the gonads away. Since it has anti-estrogenic properties it keeps your LH levels elevated and it is also said both through science and human trial that epistane may have the ability to reduce gyno. This is still a widely debated outcome of epistane but is actually showing more and more positive results as it becomes more popular. Even though users will see dry gains on epistane it does not mean that it would be any insufficient for a bulking cycle. In fact it would be beneficial because it would generate lean gains. Through research it is reported that most users who have taken this substance have gained anywhere from 5-12 lbs in a 3-5 week cycle. Now in my opinion epistane would be better in a cutting cycle to keep the body dry while preserving and potentially add more lean muscle tissue.
Most users run epistane for 1-6 weeks using a dose between 10 and 60 mgs.
You should not run this substance for longer than 6 weeks.
A recommended beginner cycle would be starting at 10 mgs for the first 2 days of the cycle and then running it like this for the rest of the cycle.
Week 1: 10 mgs for the first 2 days then increasing the dose to 20 mgs.
Week 2: 20 mgs
Week 3: 30 mgs
Week 4: 40 mgs- This week should be optional depending on how your body reacts.
While taking epistane you should be aware that it is a methylated compund therefore you should not exceed the proper dosing.
What needs to be taken with Epistane?
Even though epistane has very minimal side effects, you should still use the proper support supplements to make sure your body stays in good health throughout the cycle. Since Epistane is methylated, milk thistle is highly recomended to protect the liver values. It would also be wise to get blood work done after completing a cycle.
Red Yeast Rice- This product is a Fermented Rice product that basicly protects your cardiovascular system from any damage Sostonol that may come from Sostonol.
Celery Seed- Acts as an anti-oxidant which helps reduce blood pressure and also can aid the liver on cycle.
Hawthorne Berry: Also very useful to lower BP and keep it on check. A great on cycle supplement.
Dosage 1000mg ed on cycle.
Milk Thistle (80% standardized Silymarin)- This should be taken all the way through. It should be started as a pre load and be taken all the way through PCT(Post Cycle Therapy ).
Also you may want to look further into these products to help with blood pressure and cholesterol regulation / liver and support:
Liver: K-R-ALA, NAC ( N-Acetyl-Cysteine), Lecithin
Cholesterol: Sesathin, Guggul, CoEnzyme Q10*, Flax Seed Oil, Safflower Oil*, Policosanol*, Niacin, Garlic, Pantethine
Blood Pressure: Coenzyme Q10, Garlic ,C-12 Peptide, high-dose vitamin B6 and vitamin C.
Post Cycle Therapy (PCT)
Even though epistane does have anti-estrogenic properties, it does not mean that PCT should be avoided. A proper SERM will make sure that your natural hormone levels are back where they were before the cycle.
07-24-2009, 06:53 PM #9
thx, I have some detailed info. Epitiostanol is a relatively obscure steroid used for breast cancer that is only
available in Japan. Again you might say, “How does a drug used for breast cancer work
for us extreme fitness types?” Well, Epitiostanol was actually developed back in the
1960’s and has an
extremely good anabolic /androgenic ratio. This means that it causes a whole host of
positive effects in the body with minimal negative androgenic effects. The reason it was
used for breast cancer is that it was shown to exert a potent anti-estrogenic effect
which halted the progression of estrogen-stimulated cancers. What wonderful
characteristics to have in a steroid! Great muscle growth with small androgenic
phenomenon with no estrogenic problems like gyno…sounds like the perfect steroid!
Well, the Japanese company Shionogi thought so too but they wanted a characteristic that
epitiostanol lacked—significant oral bioavailability. The smart people at this company
went back into the literature and found that 17B steroidal ethers caused a significant
increase in oral bioavailability. They used the ether technology and voila, they created
Mepitiostane. Fortunately, they didn’t stop there! They decided to
elucidate just how these ethers work. Read below for the story!
The Shionogi research team began their quest by asking the question as to what possible
ways could the ether group be increasing bioavailability. They realized that orally
administered drugs and nutrients are transferred to the systemic circulation via the
portal and/or lymphatic route following passage through the mucosal cell of the
intestinal lumen. They also understood that the portal route is considered to be the
main route for compounds absorbed from the intestines because blood flow is about 500
times greater than lymph flow in capillaries of the villus.
Thus they first looked at the portal route and asked whether the ether group on the
steroid could be preventing the steroid from being metabolized by the liver. They looked
at the characteristics of the molecule and decided that this was probably not the right
Although not the primary place of absorption of most compounds, the intestinal lymphatic
system is known to play an important role in the absorption of some compounds such as
long chain fatty acids, triglycerides and lipid soluble vitamins. A compound absorbed
via intestinal lymphatics directly enters the systemic circulation at the level of the
subclavian vein which avoids first pass metabolism of the compound through the liver.
With this in mind, our good friends at Shionogi decided to look here for their answers.
Hey, all I can say is that these guys were right on the money! Using radioactive
labeling of both Epitiostanol and Mepitiostane, they found that Epitiostanol is almost
entirely absorbed via the portal route while mepitiostane is almost entirely absorbed
via the lymphatic route. Bingo!
One of the most fascinating things that I noticed in their research was that there are
literally a multitude of factors that determine the bioavailability of orally consumed
steroids . Intestinal absorption usually refers to the process of uptake of a compound
from the site of absorption into the systemic circulation. This process includes the
penetration through the epithelial cells, metabolism in the epithelial cells and
transfer from the epithelial cells into the portal vein or lymphatics. Any or all of
these processes can significantly cause inhibition of absorption of the parent compound.
I have heard for quite some time from various sources that methandrostenolone (Dianabol )
works much better when taken orally than injected. I used to scoff at this but now I
might be in a position to believe what I heard. You see, there is quite a bit of
research which shows that anabolic steroids undergo significant metabolism in the
epithelial cells. Consequently, ingested methandrostenolone, as well as other orally
administered steroids, could possibly be significantly converted into other active
species with highly different characteristics before it even reaches the liver!
In the magazines and advertisements, we hear all the time that taking so and so amount
of prohormone will give you thus and thus blood levels of that particular steroid. They
base this simply by saying that a certain predefined percentage makes it through
unmetabolized by the liver. They do not consider the facts that a great amount might not
get absorbed by the epithelial cells nor do they take into consideration the fact that
much might get metabolized into either more or less active species. Basically, the whole
situation is quite complex and cannot be simplified with such a sophomoric formula.
I also want to bring up the point again of how important it is to have a proper delivery
system to cause increased penetration/absorption in the epithelial cells. I dug up a
bunch of research which shows that without any type of delivery system as much as 50% of
the ingested steroid can be unabsorbed. You can guess what happens to this unabsorbed
steroid! Into the toilet my friend; into the toilet!!!
After Shionogi showed that steroidal ethers are absorbed in the lymphatic system, they
did a series of studies which determined exactly what was responsible for lymphatic
versus portal partitioning. Please understand that when the steroid is absorbed into the
epithelial cell it is PARTITIONED or directed into either the portal vein or the
lymphatic system. I already know what you are asking, “What determines the
It is a phenomenon called SUPERLIPOPHILICITY! If you remember correctly fatty acids and
triglycerides are almost completely absorbed into the lymph. Superlipophilicity makes
the compound associate so strongly with triglycerides and fatty acids that it absorbs in
a similar fashion. During absorption, superlipophilic compounds become incorporated into
the core lipids of chylomicrons in the intestinal mucosal cells of the intestinal
mucosa. These fatty chylomicrons are then transferred almost exclusively into the
lymphatic system (including the steroidal ethers).
Methepitiostane is an oral anabolic steroid derived from dihydrotestosterone. This drug
exhibits an anabolic effect that is roughly 12 times more pronounced than its androgenic
effect, and also imparts an anti estrogenic effect. RPN’s product Havoc and IBE’s
Epistane were introduced at practically the same time and considered interchangeable by
many. However, it should be noted that even when two products are identical, users can
experience different effects depending on the quality of the isomer, manufacturing
process and so on. With Havoc and Epistane they are chemically very slightly different
2a,3a-epithio-17a-methyl-5a-androstan-17b-ol 2 (Havoc), and 2,
3a-epithio-17a-methyletioallo cholan-17b-ol (Epistane). Dosages are usually in the
10-30mg range. Competitive Edge Labs E-Stane is probably the cheapest listed version of
Effects: useful for promoting solid, lean muscle gains with a concomitant reduction in
estrogen leading to a drier physique, and significant strength gains. This will
contribute to the vascularity users typically report. Havoc and Epistane are also
sometimes used purely to combat gynecomastia as they act in the body as an anti
estrogen, which also may produce some lethargy though.
Side effects: less hepatoxic and damaging to lipid levels than other orals but
Methepitiostane is a c17-alpha alkylated compound. Methepitiostane is not aromatized by
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Shionogi & Co., Ltd, Shionogi Research Laboratories, Fukushima-ku, Osaka 553, JAPON
Résumé / Abstract
Substitution of the steroid epitiostanol (EP) at position 17 with methoxycyclopentane
yields the extremely lipophilic mepitiostane (MP) with preferential partitioning into
the lymph. Most of the MP in the lymph was associated with the core lipids of
chylomicrons and very low-density lipoproteins (VLDL), as was also the case for EP.
However, the dialysis velocity of EP and MP from lymph to plasma differed greatly; EP,
but not MP, was transferred from the lymph to the plasma. This difference was attributed
to differences in their unbound fraction in the lymph. Lymphatic transfer and the logP
value of several tested steroids correlated
07-24-2009, 09:49 PM #10New Member
- Join Date
- Jul 2009
Im on 150mg ed on drol and have had no problems am uber super strong i throw hay bails around the farm like its nothing i have minor anger issues but thats all
07-24-2009, 11:36 PM #11Associate Member
- Join Date
- Jun 2009
07-24-2009, 11:38 PM #12*Anyone wanting a source check from a willing vet/mod must first acquire 100 posts and 45 days of activity*
The Young and Steroids
The official AR interview thread
Things to consider before starting a first cycle
Information regarding the new HRT therapy Nebido
The Prime explained before cycling
AAS- Tips on keeping gains for the moderate user
Short burst cycling explained
Users Browsing this Thread
There are currently 3 users browsing this thread. (0 members and 3 guests)