Half-Life

[Lockout888]

Why is the Half-Life of a topical like Axiron so different from an injectable like Cypionate ?

Axiron can bump you from 300 to 650 in 2 hours, but it goes back down to 300 or so within 24 hours.

Cypionate can do the same thing, but it takes 10 days to return to where you started?

[bass]

gels get in your blood stream immediately, where shots have a slow release.

[The Deadlifting Dog]

Topicals are straight testosterone without an ester attached. Testosterone has a half-life of something like 10-100 minutes.

Testosterone cypionate has an ester attached to the testosterone. It takes time for you body (liver I think) to cleave the ester off the testosterone molecule. Hence the long half-life.

[kelkel]

The purpose of the quick response to gels is to mimick the bodies natural rise and fall (diurnal) of endogenous testosterone . Closest thing to "natural" we have but it's a pain in the ars.....some do great on it though!

[Lockout888]

The purpose of the quick response to gels is to mimick the bodies natural rise and fall (diurnal) of endogenous testosterone. Closest thing to "natural" we have but it's a pain in the ars.....some do great on it though!

What does a normal (non-hypogonadal) rise & fall look like as far as numbers?

[The Deadlifting Dog]

What does a normal (non-hypogonadal) rise & fall look like as far as numbers?

see the attached chart:

[Lockout888]

see the attached chart:

So normal levels naturally rise about 400 ng/dl each day and then fall?

[The Deadlifting Dog]

Yes.

[xcraider37]

Yes.

Was going to comment on the chart you posted, but now that I look at it more closely, I have no comment, please disregard.