Thread: Benadryl, tylenol pm, melatonin
04-02-2002, 12:23 PM #1
Benadryl, tylenol pm, melatonin
I usually take a mix of these three drugs to go to sleep at night. Does this inhibit my REM sleep? I take these supps in order to go to bed earlier and get more sleep so my muscles will grow, but am I defeating the purpose of getting more sleep with the supps. Thanks in advance.
04-02-2002, 05:14 PM #2
04-02-2002, 08:01 PM #3
know one's replying, so i'll give this post a shot.
I heard taking unnatural sleep stuff does mess with REM sleep,
tylenol is toxic and isn't something I'd take often. ibprophen is said to affect gains. drugs in nyquil and that shit is ok once in a while, but I would not abuse that stuff at all. jmo
04-02-2002, 08:15 PM #4
I would honestly stay away from all the synthetic shit. Stick with 3mg of timed released melatonin and if you want combine it with 50mg of 5-HTP.
Normally, the body secretes melatonin for several hours per night—an effect best duplicated with time-release supplements. Studies using timed-release melatonin for insomnia have reported good results.39 Many doctors suggest 1–3 mg of melatonin taken one to two hours before bedtime. Studies with people suffering from sarcoidosis or cancer have used very high amounts of melatonin—typically 20 mg per night. Such levels should never be taken without the supervision of a doctor. Melatonin should not be taken during the day.
Melatonin is a natural hormone that regulates the human biological clock. Double-blind research with young adults has shown that melatonin facilitates sleep.1 Another study of healthy, young adults reported that melatonin significantly shortened the time needed to go to sleep, reduced the number of night awakenings, and improved sleep quality.2 Other researchers reported the time needed to get to sleep was reduced with melatonin.3
Melatonin is also helpful in relieving symptoms of jet lag. One double-blind trial, involving a sample of international flight crew members taking either melatonin or a placebo for three days before and five days after an international flight, found that melatonin significantly reduced symptoms of jet lag and resulted in a quicker recovery of preflight energy levels and alertness.4
Less than 1 mg of melatonin has lowered pressure within the eyes of healthy people,5 but studies have not yet been published on the effects of using melatonin with people who have glaucoma. Melatonin might help some people suffering from depression. A small double-blind study suggested that supplementation with small amounts of melatonin (0.125 mg taken twice per day) may reduce winter depression.6 People with major depressive disorders sometimes have sleep disturbances. Melatonin has been shown to be effective at improving the quality of sleep of people with major depression.7 However, because of the possibility that melatonin could exacerbate depression, it should only be used for this purpose, under a doctor’s supervision.
When some people take melatonin to treat sleep disorders, chronic tension headaches are relieved.8 Melatonin has also relieved cluster headaches in double-blind research.9 Some researchers have suggested that melatonin’s role in regulating core body temperature may be responsible for preventing cluster headaches,10 which have been reported to be triggered by increased body heat.11
Melatonin also regulates immunity. One group of doctors reported two successfully treated cases of sarcoidosis that it attributed to melatonin’s immune-modulating effect.12 Also, because of its effects on the immune system, melatonin has been given to people with cancer in many research trials. Low blood levels of melatonin are associated with an increased risk of uterine cancer.13 Melatonin has significantly reduced the level of prostate specific antigen (PSA, a marker for cancer) in prostate cancer patients.14 Melatonin inhibits breast cancer cells in test tubes15 and has put some women with breast cancer into remission in preliminary research.16 Melatonin supplementation has improved disease-free survival in people with melanoma17 and increased survival in people with brain cancer18 and lung cancer.19 Melatonin exerts anti-inflammatory activity that may be responsible for its anticancer properties.20
In a double-blind trial, people who had difficulty sleeping as a result of tinnitus were better able to sleep if given 3 mg melatonin per night for one month rather than a placebo.21 Although melatonin did not reduce overall symptom scores for tinnitus, people in this trial with higher symptom scores did appear to obtain some benefit.
Melatonin supplementation may be helpful in treating epilepsy; 5–10 mg of melatonin taken at bedtime reduced the frequency of seizures and improved sleep in a group of children with epilepsy in a small, preliminary trial.22 However, in a group of children suffering from neurological disorders, 1–5 mg of melatonin per night led to an increase in the rate of seizures.23 Children with a seizure disorder called “myoclonus” were reported to have been cured by supplementing with 3–5 mg of melatonin per day in a preliminary trial.24 Until more is known, children with neurological conditions should take melatonin only under medical supervision.
Melatonin may be useful in the treatment of fibromyalgia. In a small, uncontrolled preliminary study, 3 mg of melatonin at bedtime was found to reduce tender points associated with this disorder. Pain and fatigue improved only slightly.25
Children with Angelman’s syndrome (a rare, genetic disorder characterized by severe mental retardation, seizures, and sleep disturbances) may benefit from low amounts of melatonin. In an uncontrolled study, children with Angelman’s Syndrome who took 0.3 mg of melatonin one-half to one hour before bedtime had significant improvement in nighttime sleep patterns and a reduction in movement disturbances during sleep.26
Animal studies indicate that melatonin secretion may regulate cardiovascular activity,27 28 blood pressure,29 and blood flow to the brain.30 In healthy young men, oral administration of 1 mg of melatonin significantly reduced blood pressure and levels of stress hormones within 90 minutes.31 To date, no clinical trials in humans have tested the efficacy of melatonin for hypertension.
5-HTP is used by the human body to make serotonin, an important substance for normal nerve and brain function. Serotonin appears to play significant roles in sleep, emotional moods, pain control, inflammation, intestinal peristalsis, and other body functions.
In a controlled trial, 5-HTP (300 mg per day) was shown to be effective in reducing many symptoms of fibromyalgia, including pain, morning stiffness, sleep disturbances, and anxiety.8
For depression, 300 mg per day is often effective, though much of the research used 5-HTP in combination with drugs or was uncontrolled.9 10 11 For insomnia, a single 100-mg nighttime dose of 5-HTP was sufficient to improve the duration and depth of sleep in one placebo-controlled trial.12 For migraine headaches, amounts ranging from 400–600 mg per day have been shown to be effective at reducing the frequency and severity of attacks in most clinical trials.13 14 15 16 17 For tension headaches, 100 mg of 5-HTP taken three times per day led to a significant decrease in consumption of pain-relievers, but no significant change in headache duration or intensity.18
Appetite reduction and weight loss (averaging 11 pounds in 12 weeks) has occurred with amounts of 600–900 mg daily.19 20 In another clinical trial, 750 mg per day has been shown to be effective at decreasing carbohydrate and fat intake, and promoting weight loss.21
04-02-2002, 10:29 PM #5
thanks for the responses guys. Ripped, I've never heard of the 5-HTP stuff, but I'm going to do some more research on it. Thanks again.
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