Tylenol Toxicity Amounts

[Lozgod]

I was just researching Tylenol because I am taking percocets and I wanted to make sure I dont take too much and I found this article, thought I would share it.

http://headaches.about.com/cs/medica...acet_death.htm

[RoNNy THe BuLL]

It's the Acetominephene (sp?) in Tylenol that you want to worry about. Going over 5g (that's 5000mg for those who didn't pick up on it) is medically considered and overdose.

[Lozgod]

It's the Acetominephene (sp?) in Tylenol that you want to worry about. Going over 5g (that's 5000mg for those who didn't pick up on it) is medically considered and overdose.

Yeah, well the article sais anything over 4 grams in 24 hours is an OD.

[RoNNy THe BuLL]

****, I didn't even read that you were taking Percs. Then listen to what I wrote in my first post in this thread.

Do not take over 5,000mg of Acetominephine within a 24 hour period. I think percs have like 300mg Per Tab and Extra Strength Tylenol has somewhere around 250mg?

[RoNNy THe BuLL]

Yeah, well the article sais anything over 4 grams in 24 hours is an OD.

I didn't even read the article. My bro was on Percs a few weeks back after tearing his Gastrocnemius. Ouch.

[Money Boss Hustla]

Let's do some math. 5000mg would equal about 20 250mg Tylenol caplets. Who would ever take 20 caplets in one shot!?

[Lozgod]

I didn't even read the article. My bro was on Percs a few weeks back after tearing his Gastrocnemius. Ouch.

Well I have to be extra careful because I am taking them because I was having bad back pain and pissing blood, so my kidneys may already be f*cked up I dont want them to get worse.

[Lozgod]

Let's do some math. 5000mg would equal about 20 250mg Tylenol caplets. Who would ever take 20 caplets in one shot!?

In a 24 hour period its possible, and mine are 500mg each plus hydrocodone.

[RoNNy THe BuLL]

Let's do some math. 5000mg would equal about 20 250mg Tylenol caplets. Who would ever take 20 caplets in one shot!?

Percoxets you take every 2-4 hours and it can range from 1-2 tabs. Each Percoxet contains around 300mg Acetominophene. Combine that with some Extra Strength Tylenols and you're looking at possibly taking 1g of Acetominpohene in one sitting! That's pretty nuts, but people who are in pain need it.

My bro almost Overdosed on it, that's how I know what the OD dose is. Pretty nuts.

[Lozgod]

Percoxets you take every 2-4 hours and it can range from 1-2 tabs. Each Percoxet contains around 300mg Acetominophene. Combine that with some Extra Strength Tylenols and you're looking at possibly taking 1g of Acetominpohene in one sitting! That's pretty nuts, but people who are in pain need it.

My bro almost Overdosed on it, that's how I know what the OD dose is. Pretty nuts.

Well in my party days I was all drunk and without thinking grabbed a bottle of percs with like 13 in there and downed the whole bottle. That was like 2 years ago, I am wondering if doing stuff like that back in the day is causing me problems now.

[RoNNy THe BuLL]

Never know. I doubt it. Taking them all at once would actually be better then downing them consistantly over an extended period of time.

Could've been anything ranging from AAS Substance Abuse, Alcohol consumption, Diet, Work-Related Chemicals, Hereditary Genes...hell, even STRESS.

I think you should stop stressing about having a Mini-Lozgod...haha...

[birddog]

Tylenol is one of the most, if not the most, toxic drugs to your liver. I wouldn't recomend ever taking it for chronic pain. You should really use it for fevers or acute mild pain, or for children who are sick because you should not give asprin to children because it can cause reye's syndrome.

If your juicing you should be taking asprin everyday anyway to thin your blood out a little especially if taking good ole vitamin A-50.

birddog physician

[birddog]

Downing all the pills at once would be absolutely worse for you than using them long term as far as your liver goes. this is in contrast to what the bull said.

Your liver enzymes won't be able to handle the acute overdose, but overtime (chronic use) your cells smooth endoplasmic reticulum builds up a greater ability to detoxify chemicals that the cells keep facing.

[RoNNy THe BuLL]

Tylenol is one of the most, if not the most, toxic drugs to your liver. I wouldn't recomend ever taking it for chronic pain. You should really use it for fevers or acute mild pain, or for children who are sick because you should not give asprin to children because it can cause reye's syndrome.

If your juicing you should be taking asprin everyday anyway to thin your blood out a little especially if taking good ole vitamin A-50.

birddog physician

For people who don't know how Acetaminophen (Tylenol) damages the liver, Acetaminophen is metabolized in the liver. This results in a byproduct that can damage liver cells, but is quickly converted into a harmless substance by an antioxidant glutathione.

However, when large doses of acetaminophen are taken, the body's supply of glutathione becomes exhausted. This results in progressive destruction of liver cells. And it can happen in as little as five days. If large amounts of alcohol are consumed as well, this further damages the liver.

The recommended dose of Tylenol for adults depends on who you talk to. Some liver specialists say two grams a day. Others go along with the recommended dose on the Tylenol label of four grams a day. But even if you stay within the recommended dose, don't take it for more days than is advised. Unfortunately, some people continue to swallow six or eight tablets day after day. Finally, it's more than the liver can handle.

TAKEN FROM:

http://chealth.canoe.ca/health_news_...1&news_id=8514

[sinista63]

Just to clear things up.

repeated doses of > 4000 mg/day (8 tablets of extra strength tylenol) of acetaminophen can lead to a chronic tylenol toxicity. Doses of about 7.5 grams (15 tablets of extra strength tylenol) and above may lead to acute toxicity.

these thresholds are lower in those that consume alcohol on a regular basis, are malnourished, or have a pre-existing liver disease.

extra strength tylenol contains 500 mg of acetaminophen per tablet.

depending on the specific percocet strength, it can have anywhere from 325 mg to 650 mg of acetaminophen. same thing with vicodin and lortabs.

[birddog]

yeah take asprin not tylenol (acetaminophen) for pain, and also to thin your blood out a little. asprin will not raise AST and ALT levels like tylenol ie it is relatively safe

Good post Ronny the Bull.

[RoNNy THe BuLL]

Downing all the pills at once would be absolutely worse for you than using them long term as far as your liver goes. this is in contrast to what the bull said.

Your liver enzymes won't be able to handle the acute overdose, but overtime (chronic use) your cells smooth endoplasmic reticulum builds up a greater ability to detoxify chemicals that the cells keep facing.

Good point. But, there's a limit.

If you're consistanltly abusing your liver with Tylenol specifically, you're heading down faster then abusing the **** out of it one time. That goes with a lot of medication.

Yes, you will build up an ability to detoxify chemicals, but it won't happen overnight. The amount of abuse your liver would've already had to have taken in order to build up the ability to detoxify the chemicals would be far less then abusing it sporadically.

Just my two cents...

[RoNNy THe BuLL]

yeah take asprin not tylenol (acetaminophen) for pain, and also to thin your blood out a little. asprin will not raise AST and ALT levels like tylenol ie it is relatively safe

Good post Ronny the Bull.

Good post and point. Aspirin and Tylenol are both different drugs. A lot of people don't know that.

[birddog]

sinista you got to be kidding me that your taking that much tylenol. Have you looked at the whites of your eyes lately? I bet they are yellowish in color. You could have an acute failure of your liver with 4000mg a day or even 2000mg a day it is dependent on how good your liver function is. I can pretty much garauntee that you are killing a lot of hepatocytes (liver cells) if you are taking that much right now. There is no need to take that much tylenol. Bro you better get your AST and ALT checked soon if your taking that much.

[sinista63]

aspirin isn't totally benign either. continued use of aspirin may lead to GI bleeds/ulcers. also, some people need to stay away from aspirin (those with a history of GI bleeds, allergy to salicylates, those taking coumadin [warfarin], and persons with G-6-PD deficiency) which would make acetaminophen their primary option.

neither is without side effects. as with everything else, moderation is key.

also, saying that aspirin "thins" the blood is a misnomer. it just makes it more difficult for your body to form clots.

[RoNNy THe BuLL]

Either which way and/or drug, the overall consensus is to know your amounts and to talk to a registered physician. Sticking with the overall post and the research provided...

Do not go over 4-5g of Acetaminophin a day.

[sinista63]

sinista you got to be kidding me that your taking that much tylenol. Have you looked at the whites of your eyes lately? I bet they are yellowish in color. You could have an acute failure of your liver with 4000mg a day or even 2000mg a day it is dependent on how good your liver function is. I can pretty much garauntee that you are killing a lot of hepatocytes (liver cells) if you are taking that much right now. There is no need to take that much tylenol. Bro you better get your AST and ALT checked soon if your taking that much.

um.... never said that I take that much. my posting was to give hard numbers. yes, 4000 mg could put you in acute liver failure but like you said that is wholly dependent upon the current state of your liver function. the general population should be able to handle 4 grams of tylenol per day (in divided doses). but that is also dependent upon the entire course of acetaminophen therapy. i'm sure that the liver of a person taking acetaminophen at 3 grams per day for a month doesn't resemble that of someone taking 3 grams per day for 3 days.

[birddog]

sinista listen I didn't become a doctor by going to the Sally Struthers At Home Medical School. Asprin is very very very safe in comparison to tylenol. You should refrain from pretending like you know what G-6-PD deficiency is, or what warfarin is used for or even what enzyme metabolizes warfarin (cyp 3A4 and other p450 enzymes), which by the way can be affected by almost every drug, not to mention grapefruit juice. Anybody that gets warfarin from a doctor will be managed approriately I garuntee and if there are any body builders that are taking this stuff without the consult of a doctor they are morons. Furthermore, people with GI bleeds probably know not to take asprin.

Let me make a Big big blanket statement Asprin is very very very safe.

Oh your right though about the fact that it doesn't "thin" the blood, but it by preventing clots you are doing the same thing as thining the blood ie preventing strokes, emboli, heart problems.

[sinista63]

nor did i get my doctorate from at home classes either. actually... i am quite familiar with g6pd deficiency.

also, i am aware that warfarin does not interact with aspirin via the cytochrome p450 system and i never stated such a thing. the interaction is due to aspirin's impairment of platelet function. yes. i am aware that anyone on warfarin SHOULD be closely monitored but in reality this does not happen like it should. having worked at a warfarin clinic, i saw first hand how many patients would come in with INR levels all over the place and with no idea that they should refrain from taking aspirin or any NSAIDS (or at least ask their healthcare provider whether it was okay for them to take them). i was simply making a point that aspirin is not a universal panacea and that there are certain situations in which acetaminophen is a better choice. also, aspirin is not devoid of any hepatic effects. i've helped care for patients in the critical care unit that developed hepatitis from aspirin overdoses. but yes, it is less directly hepatotoxic than acetaminophen.

i like to stay away from using terms like "thinning" the blood because many laypersons do not fully comprehend what this may mean and go away with beliefs that warfarin may actually lower their blood pressure (and I have had patients tell me this on more than one occassion). look at some of the posts on AR and you'll quickly realize that many people have misconceptions about what "thinning the blood" actually means.

yes.... aspirin used in moderation is safe but those taking it should be aware of the risks of bleeding (specifically GI bleeding) associated with it (even though this is most commonly associated with older patients but can happen in younger patients as well).

my post was simply an attempt to provide more information to the AR community. my post was not an attack on you nor was i "pretending" to know what i'm talking about. you should consider who your target is and what their background is prior to belittling their statements.