Hercules gene

[drdeath613]

woohoo first time posted here

whats peoples thoughts

if they could find a way to bottle this gene for u to shoot up
would u

and could this be the new steroid in time



and yes this is a real pics

[Deltasaurus]

called Myostatin inhibitors and there working on it.

people will die young though

[CHUCKYthentic]

its called double muscle or some shite right? those dogs are called whip-its

anyway, looks cool, i personally wouldnt ever want to be that big. i could kinda imagine what a human being would look like, damn!

actually i think ronnie coleman already has that gene injected into him! LOL

[drdeath613]

well there are a few humans they have found this gene in and a few they are trying to test to see if they have it

they think this girl might have the gene
Discovery Channel My Shocking Story - Worlds Strongest Girl
but cuz of religon parents wont let her blood be tested

like i said there are a few others with this so called gene

[CHUCKYthentic]

my weiner has this gene

[Nooomoto]

Yeah they showed that "World's Strongest Boy" who is supposed to have that...the kid was like 3 years old doing pull-ups...and he wasn't trying either, just playing around.

[drdeath613]

Myostatin (formerly known as growth differentiation factor 8) is a secreted TGF beta protein family member that inhibits muscle differentiation and growth, i.e. higher concentrations of myostatin in the body cause the individual to have less developed muscles. Myostatin is produced primarily in skeletal muscle cells, circulates in the blood and acts on muscle tissue, by binding a cell-bound receptor called the Activin type II receptor.

Myostatin has been found in humans and several other mammals, as well as in birds and fish. Its functions in non-mammalian vertebrates appear to be somewhat conserved, as muscle-specific actions have been demonstrated in birds. However, it is produced in many different fish tissues, suggesting that it may regulate more than just muscle mass in these vertebrates.

[drdeath613]

During the last decades looking for ways to restore and increase muscle mass were not only using low molecular weight anabolic and anti-catabolic agents, as well as biologically active food supplements, but also at the level of searching for genes responsible for the homeostasis of muscle tissue. Object to detect such genes were, in particular, and breed of beef cattle with the phenotype of so-called "double-muscle mass" (Breed "Belgian Blue" and Piedmontese). Turning in this quest began in 1997.

Myostatin and the associated gene were discovered in 1997 by geneticists Alexandra McPherron, Se-Jin Lee and Ravi Kambadur, who also produced a strain of mutant mice that lack the gene and thereby have approximately twice as much muscle as normal mice.[1] These mice were subsequently named "mighty mice".

The gene has been sequenced in humans, mice, several other mammals and many fish species. The primary coding sequence is highly conserved among all vertebrates[2] as is the genomic organization.[3] These and other recent studies also indicate that the myostatin gene in fish has been duplicated as most fish species possess two distinct myostatin genes (MSTN-1 & -2) while salmonids have four (MSTN-1a, -1b, -2a & -2b)[4][5][6] This further suggests that the physiological and developmental aspects of myostatin biology may be quite different from that in mammals.

[drdeath613]

After that opening in the same 1997 in several laboratories cloned and have established sequence of a gene myostatin at a horned cattle of breeds «Belgian blue» and Piedmontese. It was revealed that these animals have mutations in a gene myostatin (various in each of breeds) which in one way or another lead to absence functionally active myostatin (McPherron A., Lee S-J., 1997; Grobet L. et al., 1997; Kambadur R. et al., 1997). Unlike mice to the damaged gene myostatin at these breeds occurs only hyperplasia a muscular fabric without a hypertrophy. Though with reference to this meat cattle use the term "a phenotype of the doubled muscular weight", the total increase in all muscles makes no more than 40 % in comparison with other meat breeds, but also it, is unconditional, invaluable to meat animal industries. The photo of "Belgian Blue" shows, how absence functionally active myostatin (the gene myostatin works, but the synthesized fiber is inactive) leads to increase in muscular weight.[7][8][9]

[drdeath613]

In 2004, a German boy was diagnosed with a mutation in both copies of the myostatin-producing gene, making him considerably stronger than his peers. His mother, a former sprinter, has a mutation in one copy of the gene.[10][11][12][13][14][15]

An American boy born in 2005 was diagnosed with a clinically similar condition but with a somewhat different cause.[16] In contrast to the first case, this boy produces a functional myostatin, however he has a defect in his myostatin receptor so that his muscles do not respond to the myostatin signal.

[drdeath613]

Biochemistry

Myostatin is a member of the TGF beta superfamily of proteins.

Human myostatin consists of two identical subunits, each consisting of 109 amino acid residues. Its total molecular weight is 25.0 kDa. It can be produced in genetically engineered E. coli or eukaryotic cells and the recombinant protein from both sources is commercially available. However, due to the unique manner by which the mature protein is processed, there is considerable doubt as to the effectiveness of myostatin generated in E. coli.
Clinical significance

Further research into myostatin and the myostatin gene may lead to therapies for muscular dystrophy.[18] The idea is to introduce substances that block myostatin. In 2002, researchers at the University of Pennsylvania showed that monoclonal antibody specific to myostatin improves the condition of mice with muscular dystrophy, presumably by blocking myostatin's action.

In 2005, Lee showed that a two-week treatment of normal mice with soluble activin type IIB receptor, a molecule that is normally attached to cells and binds to myostatin, leads to a significantly increased muscle mass (up to 60%).[19] It is thought that binding of myostatin to the soluble activin receptor prevents it from interacting with the cell-bound receptors.

It remains unclear whether long term treatment of muscular dystrophy with myostatin inhibitors is beneficial: the depletion of muscle stem cells could worsen the disease later on.

As of 2009[update], no myostatin-inhibiting drugs for humans are on the market, but an antibody genetically engineered to neutralize myostatin was developed by New Jersey pharmaceutical company Wyeth.[20] The inhibitor is called MYO-029, but after an initial clinical trial, Wyeth says they won't be developing the drug.[21] Some athletes, eager to get their hands on such drugs, turn to the internet, where fake "myostatin blockers" are being sold.[18]

Johns Hopkins University has developed a technique for detecting mutations in myostatin variants.[22]

[Deltasaurus]

http://www.youtube.com/watch?v=Mb6TsYsOK0A

[drdeath613]

Worlds Strongest Girl
Varya Akulova is capable of lifting up to 350kg, while she herself weighs only 40kg and she is the strongest girl in the world. This fact has already been confirmed twice by Guinness Book of World Records.
http://www.youtube.com/user/funtimef.../2/3P1A0yUjpZA

at the time this came out she was like 13 or 15 i dont remember its been a few months since i seen the whole show
and this also was the girl i was talking about who might have the gene but cant be tested cuz of religon

[lovbyts]

I hope someone teacher her how to bench properly before she hurts herself. That hurt just watching her...

[Friend]

I have it

[lovbyts]

I have it

What are you gona do with it, sell it? You arent using it...

[Friend]

What are you gona do with it, sell it? You arent using it...

You would be the first one to buy it

[ranging1]

Myostatin inhibiors have been developed and were unsuccessful

MYO-029 was the only clinical approved one that seemed plausable

after tested it was unsuccessful on patients with muscular defiecincys

the tests were then not published becuase they were deemed unsuccessful

they now are researching further into it, not for human use but for cattle farming and veterinary purposes becuase governments wont approve of genetic modification on humans

the animals u see above were genetically modified to remove that gene, which caused them to grow excessive amounts of muscle mass

the dog in that picture is now dead, as for the cow now im unaware

as for the boy, he is the first child believed to be born without the gene, however their is still not enough conclusive evidence to support this

scientists are waiting for the boy to develop further and see if the gene actually playts a serious role in his body

[ranging1]

double post

[lovbyts]

You would be the first one to buy it

Agreed, I could defiantly use it.

[CHUCKYthentic]

http://www.youtube.com/watch?v=Mb6TsYsOK0A

nice comments from you on this kid on youtube hahahaha