Interesting article on Steroid Muscle Memory

[JJ78]

Brief exposure to performance-enhancing drugs may be permanently 'remembered' by muscles

[Cuz]

ill believe it until the day I die.

[austinite]

Abstract 

Previous strength training with or without the use of anabolic steroids facilitates subsequent re-acquisition of muscle mass even after long intervening periods of inactivity. Based on in vivo and ex vivo microscopy we here propose a cellular memory mechanism residing in the muscle cells. Female mice were treated with testosterone propionate for 14 days, inducing a 66% increase in the number of myonuclei and a 77% increase in fibre cross sectional area. Three weeks after removing the drug, fibre size was decreased to the same level as in sham treated animals, but the number of nuclei remained elevated for at least 3 months (>10% of the mouse lifespan). At this time, when the myonuclei-rich muscles were exposed to overload-exercise for 6 days, the fibre cross sectional area increased by 31% while control muscles did not grow significantly. We suggest that the lasting, elevated number of myonuclei constitutes a cellular memory facilitating subsequent muscle overload hypertrophy. Our findings might have consequences for the exclusion time of doping offenders. Since the ability to generate new myonuclei is impaired in the elderly our data also invites speculation that it might be beneficial to perform strength training when young in order to benefit in senescence.

A cellular memory mechanism aids overload hypertrophy in muscle long after an episodic exposure to anabolic steroids Muscle memory induced by steroid use - Egner - The Journal of Physiology - Wiley Online Library

[JJ78]

Damn, 1 up'ed me Aust

[austinite]

haha. I read that today and figured it goes along with your thread

[JJ78]

Damn your mama is looking fine today. All Tan and ready for the pool. She is beautiful.

[qscgugcsq]

Interesting to have a study supporting this.

thanks to share