Whats the highest doasge of dbol you've ran?

[LORDBLiTZ]

I can't remember if I was doing 40mg ED or not. Regardless, I cannot ever see myself going past 40mg...my titties burn on dbol. I had to get off it fast. I would have had Dolly Parton titties from gyno. They hurt and were really itchy!!

[chel2323]

does any one know about this company AMerican pharmaceutical group llc???????

[AnabolicAlien]

i ran 100mg ed split into 25 mgs every 6 hours. got insane pumps. did this for about 6 weeks. i didn't turn yellow. my nuts didn't fall off. i didn't get roid rage . i didn't kill anyone. however, i did get a lot more vagina.

A.A.

[slob]

is there any reason that you use so much of everything you take bdtr?
Have you built up a tolerance to doses that normal people would find too high?
Or do you just do it to see how far you can push your body? Or for some other reason?
thanks.

[dtr98]

50mg for 4wks, thinking of going more next cycle

i ran 100mg ed split into 25 mgs every 6 hours. got insane pumps. did this for about 6 weeks. i didn't turn yellow. my nuts didn't fall off. i didn't get roid rage . i didn't kill anyone. however, i did get a lot more vagina.

A.A.

[Sigmund Froid]

75mg dbol with 225mg Anadrol
about 6 weeks

[Ejuicer]

60mg ed for 4 weeks

[ColdSore]

im useing 60-70mg ed now depending on how long im awake...getting strong real quick

[Pork Chop]

When i go high my nips also get hot.

Not me, my trainer is at 80mg/ED.. has been doing so for months. His liver enzimes are good.

Seems Dbol can be run for longer than the gospel 4-6weeks.

[ColdSore]

When i go high my nips also get hot.

Not me, my trainer is at 80mg/ED.. has been doing so for months. His liver enzimes are good.

Seems Dbol can be run for longer than the gospel 4-6weeks.

im gonna go 6-8 weeks and see what happens

[Pork Chop]

im gonna go 6-8 weeks and see what happens

The first sign your liver is taxed is the white of your eye turning yellow.
Then it's pains in lower abdomen and your skin turns yellow.

[ColdSore]

The first sign your liver is taxed is the white of your eye turning yellow.
Then it's pains in lower abdomen and your skin turns yellow.

****...thats good to know...i learned something today

[imann]

I have ran as much as 80 mg a day............we wre taking them horribley random.....I mean we were eating them like pez candy....that continued for about 5 1/2 weeks.............I got horrible night sweats.........i would not recommend running more than 50 mg's a day.............hind sight is a MF

[workdude]

25mg ED for 4 weeks. I don't think i'd go much higher or longer.

[BigMike J]

30 mgs a day/ 5 weeks.

[BigMike J]

I have actually thought about doing 50mg/day for 8 weeks. I want to know how toxic they really are.

For some reason i don't think they are any worse then the rec drugs i have done in the past. for long periods of time.


I will have to get my liver checked first. Make sure my liver is doing ok.

[IronAdam]

does any one know about this company AMerican pharmaceutical group llc???????

You need to start a new thread of your own when your asking questions. But you're not supposed to be asking about sources in the open anyway. If I were you I'd stay away from that site...they are most likely scammers.

[IronAdam]

As long as this thread is bumped...40mg/4 weeks, No need to go higher for now.

[AnabolicAlien]

it's already been mentioned but just because someone else (like me) can handle 100mg dbol over an extended period of time doesn't mean you can.

take too much dbol and you might look like this:



at least you'll look all jacked in your coffin!

A.A.

[kaptainkeezy04]

good god yall...too much dbol or any steroid for taht matter will fvck up yalls receptor sites.

[AnabolicAlien]

kaptain!! screw receptor sites - just look at that guy's head!

A.A.

[Anhydro78]

Supposed 50mgs of Reforvit-B injected for 8 weeks. ANd I loved it.

[kaptainkeezy04]

hhahaha you are funny anabolicalien...but yea i will never do more than 30mg a day...what i am doing on my first cycle as far as dbol goes is:
15mg ed for the first week
20mg ed for the second week
30mg ed for the third week
20mg ed for the 4th week
10mg ed for the 5th week

This way you dont lose everything all at once and dont get all depressed and you give your receptor sites a rest.

[kaptainkeezy04]

yeah dude take 50mg a day and GET REAL FVCKING HUGE...and have a penis that doesnt do nothing but flap around all day.

[AnabolicAlien]

kaptain!! i was sporting a "horse cock" while taking that much dbol . as a matter of fact i resorted to dating a girl who worked at HOOTERS just to satisfy my seemingly neverending sexual urges.

PM me for pics i can't post...

A.A.

[kaptainkeezy04]

yeeah dude my sex drive is off the fvcking chain right now but too much of that **** will fvck up your natural testosterone production.

[Anhydro78]

What are you talking about kaptainkeezy?? D-bol is the **** all the way around. There is no problem with erections while on D-bol alone let alone D-bol and Test. That just makes for a big dose of man juice.


There is no reason to ramp your dose anything like that. The reason people start with a lower dose and raise within Days is to see if they can handle taking Dbol . With 30mgs that wouldnt even be needed. And when it is ramped it is done like day 1,2,3,4

I think you have the receptor deal wrong so I will post something for you.

[Anhydro78]

Receptor Down Regulation
Brian Haycock


There is as much misinformation about steroids as there is good information had among bodybuilding enthusiasts. Go to any gym and you will hear some kid spouting off to his buddies about how steroids do this, or how they do that, or whatever. This soon starts somewhat of a pissing contest (excuse the expression) as to who knows more about steroids. It’s the same kind of titillating and infectious banter that adolescent boys get into about girls and sex. With steroid banter you hear all the popular terms like Deca , Test, GH, gyno, zits, raisins, "h-u-u-u-ge", roid, freak, monster, roid-rage, "I knew this guy once", etc., etc.. If by some rare chance they are smart and have been reading this or some other high quality bodybuilding site on the net, they may actually get a few details right. More often than not they know just enough to be dangerous. Fortunately steroids haven’t proven to be all that dangerous. Not only that, but most of these guys who are infatuated with steroids won’t ever use or even see them except in magazines.

This kind of ego driven gym talk doesn’t really bother me until they begin giving advice to other clueless people who actually have access to them. Spewing out steroid lingo gives other less experienced kids the impression that these kids actually know what they are talking about. That’s how all of the psuedo-science folklore about steroids perpetuates. This is also why most people who actually use steroids know little about them. This last fact should bother anyone who cares about bodybuilding and/or bodybuilders.

I started out with this article planning on giving some textbook style explanation as to why using steroids doesn’t down regulate androgen receptors (AR). Then after considering some of my critics views that I tend to write articles that hardly anyone can read, I decided to write an easy to read, yet informative explanation about what androgens actually do and how this precludes androgen receptor down regulation. I still have a few references but not so many that it looks like a review paper.

Androgen receptors down-regulate….Don’t they?

One misunderstood principle of steroid physiology is the concept of androgen receptors (AR), sometimes called "steroid receptors", and the effects of steroid use on their regulation. It is commonly believed that taking androgens for extended periods of time will lead to what is called AR "down regulation". The premise for this argument is; when using steroids during an extended cycle, you eventually stop growing even though the dose has not decreased. This belief has persisted despite the fact that there is no scientific evidence to date that shows that increased levels of androgens down regulates the androgen receptor in muscle tissue.

The argument for AR down-regulation sounds pretty straightforward on the surface. After all, we know that receptor down-regulation happens with other messenger-mediated systems in the body such as adrenergic receptors. It has been shown that when taking a beta agonist such as Clenbuterol , the number of beta-receptors on target cells begins to decrease. (This is due to a decrease in the half-life of receptor proteins without a decrease in the rate that the cell is making new receptors.) This leads to a decrease in the potency of a given dose. Subsequently, with fewer receptors you get a smaller, or diminished, physiological response. This is a natural way for your body to maintain equilibrium in the face of an unusually high level of beta-agonism.

In reality this example using Clenbuterol is not an appropriate one. Androgen receptors and adrenergic receptors are quite different. Nevertheless, this is the argument for androgen receptor down-regulation and the reasoning behind it. The differences in the regulation of ARs and adrenergic receptors in part show the error in the view that AR down-regulate when you take steroids. Where adrenergic receptor half-life is decreased in most target cells with increased catecholamines, AR receptors half-live’s are actually increased in many tissues in the presence of androgens.1

Let me present a different argument against AR down-regulation in muscle tissue. I feel that once you consider all of the effects of testosterone on muscle cells you come to realize that when you eventually stop growing (or grow more slowly) it is not because there is a reduction in the number of androgen receptors.

Testosterone : A multifaceted anabolic

Consider the question, "How do anabolic steroids produce muscle growth?" If you were to ask the average bodybuilding enthusiast I think you would hear, "steroids increase protein synthesis." This is true, however there is more to it than simple increases in protein synthesis. In fact, the answer to the question of how steroids work must include virtually every mechanism involved in skeletal muscle hypertrophy. These mechanisms include:

· Enhanced protein synthesis

· Enhanced growth factor activity (e.g. GH, IGF-1, etc.)

· Enhanced activation of myogenic stem cells (i.e. satellite cells)

· Enhanced myonuclear number (to maintain nuclear to cytoplasmic ratio)

· New myofiber formation

Starting with enhanced growth factor activity, we know that testosterone increases GH and IGF-1 levels. In a study by Fryburg the effects of testosterone and stanozolol were compared for their effects on stimulating GH release.2 Testosterone enanthate (only 3 mg per kg per week) increased GH levels by 22% and IGF-1 levels by 21% whereas oral stanozolol (0.1mg per kg per day) had no effect whatsoever on GH or IGF-1 levels. This study was only 2-3 weeks long, and although stanozolol did not effect GH or IGF-1 levels, it had a similar effect on urinary nitrogen levels.

What does this difference in the effects of testosterone and stanozolol mean? It means that stanozolol may increase protein synthesis by binding to AR receptors in existing myonuclei, however, because it does not increase growth factor levels it is much less effective at activating satellite cells and therefore may not increase satellite cell activity nor myonuclear number directly when compared to testosterone esters. I will explain the importance of increasing myonuclear number in a moment, first lets look at how increases in GH and IGF-1 subsequent to testosterone use effects satellite cells…

In part 2 we will discuss the role of satellite cells and myonuclei and how testosterone (androgens) activates these systems to create muscle growth far beyond what simple activation of the androgen receptor can produce.

In part 1 of this article we discussed the mistake of thinking about androgen receptors (testosterone receptors) in the same way we think of other receptors such as beta-receptors. Beta-receptors down regulate in response to beta-adrenergic stimulation whereas there is good evidence that androgen receptors increase in numbers in response to androgens. We also discussed the various affects of testosterone on muscle growth. Testosterone does far more than simply increase the rate of protein synthesis!

Now in part 2 we will finish our discussion of androgen receptor regulation as it pertains to the way muscle cells grow. The very mechanism of real muscle growth opens the door for increased androgen receptor number in response to testosterone treatment.

Don’t forget Satellite cells!

Satellite cells are myogenic stem cells, or pre-muscle cells, that serve to assist regeneration of adult skeletal muscle. Following proliferation (reproduction) and subsequent differentiation (to become a specific type of cell), satellite cells will fuse with one another or with the adjacent damaged muscle fiber, thereby increasing the number of myonuclei for fiber growth and repair. Proliferation of satellite cells is necessary in order to meet the needs of thousands of muscle cells all potentially requiring additional nuclei. Differentiation is necessary in order for the new nucleus to behave as a nucleus of muscle origin. The number of myonuclei directly determines the capacity of a muscle cell to manufacture proteins, including androgen receptors.

In order to better understand what is physically happening between satellite cells and muscle cells, try to picture 2 oil droplets floating on water. The two droplets represent a muscle cell and a satellite cell. Because the lipid bilayer of cells are hydrophobic just like common oil droplets, when brought into proximity to one another in an aqueous environment, they will come into contact for a moment and then fuse together to form one larger oil droplet. Now whatever was dissolved within one droplet (i.e. nuclei) will then mix with the contents of the other droplet. This is a simplified model of how satellite cells donate nuclei, and thus protein-synthesizing capacity, to existing muscle cells.

Enhanced activation of satellite cells by testosterone requires IGF-1. Those androgens that aromatize are effective at not only increasing IGF-1 levels but also the sensitivity of satellite cells to growth factors.3 This action has no direct effect on protein synthesis, but it does lead to a greater capacity for protein synthesis by increasing fusion of satellite cells to existing fibers. This increases the number of myonuclei and therefore the capacity of the cell to produce proteins. That is why large bodybuilders will benefit significantly more from high levels of androgens compared to a relatively new user.

Testosterone would be much less effective if it were not able to increase myonucleation. There is finite limit placed on the cytoplasmic/nuclear ratio, or the size of a muscle cell in relation to the number of nuclei it contains.4 Whenever a muscle grows in response to training there is a coordinated increase in the number of myonuclei and the increase in fiber cross sectional area (CSA). When satellite cells are prohibited from donating viable nuclei, overloaded muscle will not grow.5,6 Clearly, satellite cell activity is a required step, or prerequisite, in compensatory muscle hypertrophy, for without it, a muscle simply cannot significantly increase total protein content or CSA.

More myonuclei mean more receptors

So it is not only true that testosterone increases protein synthesis by activating genetic expression, it also increases the capacity of the muscle to grow in the future by leading to the accumulation of myonuclei which are required for protein synthesis. There is good reason to believe that testosterone in high enough doses may even encourage new fiber formation. To quote the authors of a recent study on the effects of steroids on muscle cells:

"Intake of anabolic steroids and strength-training induce an increase in muscle size by both hypertrophy and the formation of new muscle fibers. We propose that activation of satellite cells is a key process and is enhanced by the steroid use."7

Simply stated, supraphysiological levels of testosterone give rise to increased numbers of myonuclei and thereby an increase in the number of total androgen receptors per muscle fiber. Keep in mind that I am referring to testosterone and testosterone esters. Not the neutered designer androgens that people take to avoid side effects.

Another group of researchers are quoted as saying:

"…it is intriguing to speculate that the upregulation of AR levels via the administration of pharmacological amounts of androgens might convert some muscles that normally have a minor or no response to muscles with enhanced androgen responsiveness"(8)

This is not an argument to rapidly increase the dosages you use. It takes time for these changes to occur and the benefits of higher testosterone levels will not be immediately realized. It does shed some light however on the proportional differences between natural and androgen assisted bodybuilders physiques.

Maintenance of the kind of muscle mass seen in top-level bodybuilders today requires a given level of androgens in the body. That level will vary from individual to individual depending on their genetics. Nevertheless, if the androgen level drops, or if they were to "cycle off" the absolute level of lean mass will also drop. Likewise, as the level of androgens goes up, so will the level of lean mass that individual will be able to maintain. All of this happens without any evidence of AR down regulation. More accurately it demonstrates a relationship between the amount of androgens in the blood stream and the amount of lean mass that you can maintain. This does not mean that all you need is massive doses to get huge. Recruitment of satellite cells and increased myonucleation requires consistent "effective" training, massive amounts of food, and most importantly, time. Start out with reasonable doses. Then, as you get bigger you can adjust your doses upwards.

References:

1. Kemppainen JA, Lane MV, Sar M, Wilson EM. Androgen receptor phosphorylation, turnover, nuclear transport, and transcriptional activation. Specificity for steroids and antihormones. J Biol Chem 1992 Jan 15;267(2):968-74

2. Fryburg DA., Weltman A., Jahn LA., et al: Short-term modulation of the androgen milieu alters pulsatile, but not exercise- or growth hormone releasing hormone-stimulated GH secretion in healthy men: Impact of gonadal steroid and GH secretory changes on metabolic outcomes. J Clin Endocrinol. Metab. 82(11):3710-37-19, 1997

3. Thompson SH., Boxhorn LK., Kong W., and Allen RE. Trenbolone alters the responsiveness of skeletal muscle satellite cells to fibroblast growth factor and insulin -like growth factor-I. Endocrinology. 124:2110-2117, 1989

4. Rosenblatt JD, Yong D, Parry DJ., Satellite cell activity is required for hypertrophy of overloaded adult rat muscle. Muscle Nerve 17:608-613, 1994

5. Rosenblatt JD, Parry DJ., Gamma irradiation prevents compensatory hypertrophy of overloaded extensor digitorum longus muscle. J. Appl. Physiol. 73:2538-2543, 1992

6. Phelan JN, Gonyea WJ. Effect of radiation on satellite cell activity and protein expression in overloaded mammalian skeletal muscle. Anat. Rec. 247:179-188, 1997

7. Kadi F, Eriksson A, Holmner S, Thornell LE. Effects of anabolic steroids on the muscle cells of strength-trained athletes. Med Sci Sports Exerc 1999 Nov;31(11):1528-34

8. Antonio J, Wilson JD, George FW. Effects of castration and androgen treatment on androgen-receptor levels in rat skeletal muscles. J Appl Physiol. 1999 Dec;87(6):2016-9.

[kaptainkeezy04]

dude you obv. didnt read my previous post...im on test and dbol right now and im horny all day long but like i said...too much roids can cause your body to stop naturally producing natural T.

[AnabolicAlien]

screw it.... here's one i found that i can post.

poor girl... dbol , test, eq... she never had a chance

A.A.

[Anhydro78]

Yeah I have read your posts im not trying to be a dick but im not sure you understand what receptor site is. Why do you keep saying alot of hormones screws up your receptor sites???

It doesnt matter if you take 100mgs or 3,000mgs your testosterone is still suppressed.


Im just trying to see what you are getting at.

[Anhydro78]

I dated a Hooters girl too, mine had bigger Tits. Nananana

[AnabolicAlien]

Freshman girl oh so shy, is staring at the sophmore guy.
The sophomore guy with his head in a whirl, is looking at the junior girl.
The Junior girl in her red sudan, is staring at the senior man.
The senior man, hot and wild, secretly loves the freshman child.

Live for the nights you can't remember... with the girls you will never forget.

she had just turned 18 and i was 26 in that pic...

A.A.

[kaptainkeezy04]

okay here is waht i am getting at.........GET READY....

[kaptainkeezy04]

everytime you cycle, after your cyle your natural testosterone production is lower than it was before....so if you do a huge cycle with lets say 100mg of dbol a day and 1500mg of test a week, your natural test production will go way down after you are done cycling...my current cycle goes like this.....

8 weeks of anabolic /androgenic cycle..dbol test and deca
4 weeks off
6 weeks of anabolic cycle...winny, eq, primo...that stuff
2 weeks off
another anabolic cycle for 4 weeks...dunno what it is yet...my trainer has it lined up

[Anhydro78]

You are ate up Alien... But I agree its all the azz we got when we where younger that is gonna keep us going in our older years..

[AnabolicAlien]

her "tits" were just fine...

it was her as$ and the way she danced that would blow your mind

A.A.

[Anhydro78]

You have a PM kaptainkeezy..

[kaptainkeezy04]

no i dont have a pm from you

[ibiza69]

75mg/day for 7 weeks, lowerback started getting a really dull pain, havn't used an oral for over a year and a half, gonna get more d-bol this winter though wanting to start at 50 and see how i feel.