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01-21-2005, 08:03 PM #1Member
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how long to load letro before starting test
hey
im gonna do a cycle that looks like this:
1-15 Eq 400mg/w
1-18 test prop 100mg/eod
clomid PCT, with Nolva
how long should i be taking letro before i start taking the test? ill be takin 1.25mg/eod
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01-21-2005, 08:11 PM #2
2 weeks so it will get blood levels peaked.
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01-22-2005, 10:06 AM #3VET Retired
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Test does not take 2 weeks to kick-in. From the first shot you'll have higher than normal blood testosterone levels .
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01-22-2005, 10:34 AM #4Originally Posted by big k.l.g
gsxxr - I start all anti-e's 2 weeks prior to my cycle starts........... this way I have my blood levels peaked before I start using any AAS.
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01-22-2005, 12:14 PM #5Originally Posted by TheMudMan
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01-22-2005, 12:22 PM #6Member
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i hope you guys all know i was refering to test propionate , and not enanthate or cypionate
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01-22-2005, 12:23 PM #7Member
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any one know if letro has any effect on acne? like supressing it or increasing it?
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01-22-2005, 12:41 PM #8New Member
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Originally Posted by TheMudMan
Letro has a half life of about 1 1/2 days, so you should have a max blood concentration in about 5 days given that you take it ed.
For me that small amount of AAS would not call for the use of an anti e, but everyone does respond differently so the choice is yours....
badham
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01-22-2005, 01:03 PM #9Originally Posted by TheMudMan
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01-22-2005, 09:50 PM #10Originally Posted by badham
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01-22-2005, 10:22 PM #11New Member
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Originally Posted by TheMudMan
badham
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01-23-2005, 06:57 AM #12Originally Posted by badham
Here's just one of the many article/study that I have on letro/femara:
================================================== =====
R E F E R E N C E
1. Turnidge J. What to use instead of flucloxacillin. Aust Prescr 1995;18:54-6.
Letrozole
Femara (Novartis)
2.5 mg tablets
Indication: breast cancer
Antioestrogens such as tamoxifen are often used in the treatment of advanced breast cancer. In postmenopausal women, including those whose menopause has been induced by treatment, oestriol can be produced by other tissues. This synthesis can be stopped by inhibiting the aromatase enzymes. Anastrozole is already available for postmenopausal women with advanced breast cancers which have progressed following treatment with tamoxifen. Letrozole, another non-steroidal aromatase inhibitor, is now also approved for the same indication.
In a pivotal clinical trial, letrozole was not compared with anastrozole. The comparator was megestrol acetate, a synthetic progestogen. The 551 patients were randomised to receive daily doses of 0.5 mg or 2.5 mg of letrozole or 160 mg megestrol. The overall response rate was 24% in patients given 2.5 mg letrozole. Only 13% of the women given 0.5 mg letrozole and 16% of those given megestrol had a response to treatment. The median time before treatment failed was longest (155 days) in the patients given 2.5 mg letrozole.
Letrozole is taken once a day until the cancer progresses. It is well absorbed and rapidly distributed. The drug is slowly metabolised and then excreted mainly in the urine. As the metabolism may involve cytochrome P450 3A4 and 2A6, there is a potential for interactions with other drugs metabolised by these enzymes. The half-life of letrozole is two days and its concentration takes 2-6 weeks to reach a steady state.
Some of the adverse reactions of letrozole can be predicted by its effects on oestradiol synthesis e.g. hot flushes. The most common adverse effects are headache, nausea and peripheral oedema. In the pivotal study, letrozole was generally better tolerated than megestrol.
Women with breast cancer and their doctors will need to consider carefully the risks and benefits of letrozole. Its efficacy in oestrogen-receptor negative tumours is not yet known. Although letrozole has a higher response rate than megestrol, the median time to progression is not significantly different. When the data from the pivotal trial were collected, there were no statistically significant differences in the risk of death or the median time to death. At that stage, 58% of the women taking letrozole (2.5 mg) and 50% of those taking megestrol were still alive. If further study finds that letrozole has no greater effect on survival than megestrol, patients may still prefer letrozole (or anastrozole) as it is better tolerated.Last edited by TheMudMan; 01-23-2005 at 07:14 AM.
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01-23-2005, 07:13 AM #13Originally Posted by TheMudMan
Good Reference material, MudMan....you must have accumulated a library of info ...
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01-23-2005, 07:19 AM #14Originally Posted by almostgone
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01-23-2005, 07:23 AM #15Originally Posted by TheMudMan
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01-23-2005, 09:06 AM #16New Member
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Originally Posted by TheMudMan
From a biochemical stand point half life determines how much compound is cleaved and is available for use by the body (in this case the liver) at a given time, and certain metabolites are broken slower then others.......but once again this is simply an observation from a shear biochemical standpoint...you could has easily said take the letro for 6 weeks and used that particular study to back it, but with no other drugs in the system we both know that is not the case....using your own data...not busting your balls....just an observation on my part....
Letrozole is taken once a day until the cancer progresses. It is well absorbed and rapidly distributed. The drug is slowly metabolised and then excreted mainly in the urine. As the metabolism may involve cytochrome P450 3A4 and 2A6, there is a potential for interactions with other drugs metabolised by these enzymes. The half-life of letrozole is two days and its concentration takes 2-6 weeks to reach a steady state.
In my opinion all studies have to be analysed and then judged against the peer group they are being used in.....not just taken ad hoc....Just MHO.
badham
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01-23-2005, 09:18 AM #17Originally Posted by badham
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01-23-2005, 09:23 AM #18VET Retired
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Mudman is correct. Letro is best started 2-3 weeks before cycle.
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01-23-2005, 01:33 PM #19New Member
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Originally Posted by TheMudMan
and a side note some of those same professionals will be the ones that tell you not to take AAS for a host of reasons true and untrue. Simply like to know real life reasoning behind a statement....not just because someone said it....sorry it insulted you..
badham
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01-23-2005, 01:46 PM #20based on the half life of the drug
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01-23-2005, 01:54 PM #21New Member
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Originally Posted by Duke of Earl
badham
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04-01-2005, 02:18 AM #22
some people were asking about letro and how long to reach steady blood level concentrations. this is an old thread that i found infomative.
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