Metribolone looking better and better.

[TheIronBull]

AR binding,PR binding

J Biol Chem. 2000 Aug 25;275(34):26164-71.

Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations.

Matias PM, Donner P, Coelho R, Thomaz M, Peixoto C, Macedo S, Otto N, Joschko S, Scholz P, Wegg A, Basler S, Schafer M, Egner U, Carrondo MA.

Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Apartado 127, 2780 Oeiras, Portugal.

The crystal structures of the human androgen receptor (hAR) and human progesterone receptor ligand-binding domains in complex with the same ligand metribolone (R1881) have been determined. Both three-dimensional structures show the typical nuclear receptor fold. The change of two residues in the ligand-binding pocket between the human progesterone receptor and hAR is most likely the source for the specificity of R1881 to the hAR. The structural implications of the 14 known mutations in the ligand-binding pocket of the hAR ligand-binding domains associated with either prostate cancer or the partial or complete androgen receptor insensitivity syndrome were analyzed. The effects of most of these mutants could be explained on the basis of the crystal structure.

Ok, correct me if I am wrong (please be wrong!), if I am understanding this correctly, what this is basically saying is:

Metribolone causes a change of two residues (mutates them) in the ligand-binding pocket between the human progesterone receptor and the human androgen receptor.

Based on the structural implications of the 14 known mutations in the ligand-binding pocket, it is either prostate cancer or the partial or complete androgen receptor insensitivity syndrome.

[oswaldosalcedo]

So who is seeing actual feedback from it and is it reliable information ?

Arent there other issues that should be taken into account before we assume it's not as bad as we have been lead to believe ?

Oswaldo kinda scared me a little bit with that study, unless I am taking it out of context.

perhaps you do not have these mutations (pre existent)

[guest589745]

perhaps you do not have these mutations (pre existent)

Pre existing mutation is required to cause cancer then ?

I thought that it causeed the mutation by binding so tightly but, that study is a little too complex for me.

[TheIronBull]

perhaps you do not have these mutations (pre existent)

Ossie buddy,
do you have any idea what percentage of people have these pre-existent mutations?

Not that it matters much.... I don't think I shall give Metribolone a try, not worth the risk. This really suckkkkkkssss! :

Anyways,
Ossie..... you are the man

Thanks for the info!!!

[TheIronBull]

Bump

[notorious_mem]

bump

[oswaldosalcedo]

Ok, correct me if I am wrong (please be wrong!), if I am understanding this correctly, what this is basically saying is:

Metribolone causes a change of two residues (mutates them) in the ligand-binding pocket between the human progesterone receptor and the human androgen receptor.

Based on the structural implications of the 14 known mutations in the ligand-binding pocket, it is either prostate cancer or the partial or complete androgen receptor insensitivity syndrome.

i posted only mutations for prostate cancer,there are others for receptor insensitivity syndrome and other diseases.

ANDROGEN RECEPTOR GENE MUTATIONS DATABASE:

http://www.androgendb.mcgill.ca/AR23C.pdf

Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations

http://www.jbc.org/cgi/content/full/275/34/26164

or

http://www.jbc.org/cgi/content/full/275/34/26164.pdf


incidence is between 100-250 x 100.000 people.
in african americans is higher,in american indians/alaskan natives less,
whites, the second.

[goose]

Ossie good to see you around....

Have you run INTERLEUKIN -15 or DNP yet?

You still FAT,LOL. Or muscle corpse?

[oswaldosalcedo]

Ossie good to see you around....

Have you run INTERLEUKIN -15 or DNP yet?

You still FAT,LOL. Or muscle corpse?

............lol.............

so so .................lol..............

hi goz

[guest589745]

Would AR inesesetivity syndrome cause a non response to exogenous androgens ?

How do you know if you have this or not ?

[guest589745]

Oh hell no, I just lookde it up, it aint me, I aint feminine lol

[guest589745]

You would basically look feminine and have feminine characteristics if you had that syndrome even partially. I dont think that is a worry for a lot of us.

[BajanBastard]

Oh hell no, I just lookde it up, it aint me, I aint feminine lol

Well

[guest589745]

Well

**** you and the xbox 360 you rode in on !!!!

[BajanBastard]

**** you and the xbox 360 you rode in on !!!!

Shut up you primo using, PS3 loving dog! Now sendme my 10g tren !

[guest589745]

Shut up you primo using, PS3 loving dog! Now sendme my 10g tren!

Oh ok sure, no prob.


*Begins putting boldenone prop in trenbolone acetate package..........

[*Narkissos*]

^^ bold-prop-pwned!

[BajanBastard]

Oh ok sure, no prob.


*Begins putting boldenone prop in trenbolone acetate package..........

Ha! ha! ha! That would defeat most men but i can smell tren like a shark can small blood in the water.

[guest589745]

Ha! ha! ha! That would defeat most men but i can smell tren like a shark can small blood in the water.

*Begins mixing tren /cyanide combo.