Pyramiding

[KJSolid]

I know that the question of whether to pyramid helps or not has been asked and I have read the responses. Seems as some like it and others do not. My question is does anyone know of any studies suggesting this is good or bad as I searched and could not find any scientific proof of either. Thanks in advance.

[magic32]

I haven’t seen any studies, but “like” and “dislike” are far too subjective to carry weight in such a matter. Objectively, the fact is that hormones work based on bloodstream accumulation, thus we seek what is called the “steady state” a level at which the administered dosage is best maintained (as opposed to degraded) for the longest time. An understanding of this methodology negates the pro and con sides of the debate because pyramiding upward increases the time to steady state, while doing so downward decreasing the time to back to degradation. Obviously these conditions are not desirable, and consequently neither is pyramiding...in the case of gear. However, it does have very valid applications in other scenarios.

[KJSolid]

Thanks Magic. When I started years ago I used to pyramid but have not done so lately. Just wondering if I was doing what was right. And coming from a vet like you the information is worth listening to. I appreciate it.

[nowdenlid]

yes thats a great post always good to have people like you on here .......