Progesterone and prolactin induced gynecomastia

[EpyoN]

Im failing to understand how prolactin or progesterone come to be. Do certain hormones convert into prolactin or progesterone when there is an excess?

[songdog]

Good job bro.

[DanB]

I been looking for this thread, couldnt remember who wrote it

Admin where are you? Sticky!

[kelkel]

Saved it to my favorites. Another excellent thread! Damn.

[bob87]

oops replied to old post

[bob87]

oops replied to old post

[Lemonada8]

Im failing to understand how prolactin or progesterone come to be. Do certain hormones convert into prolactin or progesterone when there is an excess?

they are natural hormones in the human body, that play a key part in sexual differences. Estrogen is a major stimulator when it comes to them doing certain actions.

aka, prolactin by it self doesnt do much, but when there are high estrogen levels, it increses the breast tissue to begin to grow and lactate (similar to a preggo woman breast feeding) but in males, since we dont have that much of dominance of estrogen in our bodys (testosterone is our main one) that function doesnt occur.
Think of the word "gynecomastia ' which literally means "women breast" when broken down to the original greek term definations. normally this doesnt happen in males, and if it does its due to a hormonal imbalance ( mens breasts dont get NEARLY the size of a preggo womans) so its more of a cosmetic thing than anything else.

Prolactin is released from the pituitary gland, and is usually controlled by Dopamine. (thats why its suggested to take dopamine agonists *caber, bromo* to couteract those effects) however the down side is that they are pretty potent drugs and not to be taken lightly. Personally, i would go with tamox, vit b6, and the supplement L-Dopa before taking one of those dopamine agonists. but thats a side issue, and im not wanting to start a debate on that type of stuff, just trying to answer ur question as thorough as i can (b/c im procrastinating from studying :P) but the main effects of prolactin that would cause gyno are minimal without the presence of elevated estrogen. The estrogen makes the prolactin 'more effecient' at its biological function for breast growth. (probably due to the genome changes that estrogen induces to the DNA which slows certain proteins from being made to others being made more... hence estrogen being carcinogenic in males b/c we dont need nearly the same amount of changes as women do)

Progesterone is considered the 'mother of all hormones' (behind pregnenolone *for those scholars out there :P ) that it is the first step in the hormone transformation in the body and can become any part of the 4 major hormones in the body (Progestins, mineralocorticoids, androgens, estrogens) check out this graph which explains the process a lil better of how they all interact . There really isnt a true 'progesterone induced' gyno, because thats way to early in the hormonal process to determine that is the cause.

Basically the end line is that if you control your estrogen levels while on a cycle, then prolactin issues shouldnt be a problem. And the best thing for *gyno only* is tamox (nolvadex )... (yet rolaxifene is showing some good progress, its a newer drug with a different structure but still looks good for the future)

[DanB]

I shall bump this thread

[bob87]

It's a great thread.

[DanB]

I shall bump this thread

getting deja vu

[blacksmoke]

Bump

[Scabtree]

Gotta love information with references. It's so rare; thanks D7M.

[DanB]

Its about time for me to bump this again

[AnabolicDoc]

I recently read an article abstract that compared raloxifene vs tamoxifen in treating gynecomastia in prepubescent males and the results favored raloxifene, which is also known as Evista. The dosage is 60mg per day.

I tried to include the article in my post but when I do so my post keeps getting denied. So if u want to see the article, go to PubMed and search for it.

FYI, this is my first post and I'm new to the site.

[kelkel]

Here you go AD. http://www.ncbi.nlm.nih.gov/pubmed/15238910

You have to be here a bit before your allowed to post links or PM other members. Safety method to avoid scammers, etc.

Welcome to the forum AD!

kel

[AnabolicDoc]

Thank you.

[AnabolicDoc]

It is commonly believed that an elevated prolactin level is most often due to stress, physical and/or mental, and should always be rechecked before starting medication.

I posted this just as a reminder for those who privately check their own blood work and obtain medication, without a doctor (or if you're seeing a doctor who's not entirely competent). Double checking prolactin levels could spare you a wrong diagnosis, unnecessary grief, cost, side effects, and imaging tests (looking for a prolactinoma).

[DanB]

new years bump ! ! ! ! ! ! ! ! ! ! ! ! ! ! !