Testicular Cancer, past or present? Dont use Nandrolone or Stanozolol

**Swifto** · 07-26-2011, 05:16 PM

J Cell Physiol. 2011 Jul 18. doi: 10.1002/jcp.22936.

[Epub ahead of print]

Nandrolone and stanozolol induce Leydig cell tumor proliferation through an estrogen-dependent mechanism involving IGF-I system.

Chimento A, Sirianni R, Zolea F, De Luca A, Lanzino M, Catalano S, Andò S, Pezzi V.
SourceDepartment of Pharmaco-Biology, University of Calabria, 87036 Arcavacata di Rende, Cosenza, Italy.

Abstract
Several substances such as anabolic androgenic steroids (AAS), peptide hormones like insulin -like growth factor-I (IGF-I), aromatase inhibitors and estrogen antagonists are offered via the internet, and are assumed without considering the potential deleterious effects that can be caused by their administration. In this study we aimed to determine if nandrolone and stanozolol , two commonly used AAS, could have an effect on Leydig cell tumor proliferation and if their effects could be potentiated by the concomitant use of IGF-I. Using a rat Leydig tumor cell line, R2C cells, as experimental model we found that nandrolone and stanozolol caused a dose-dependent induction of aromatase expression and estradiol (E2) production. When used in combination with IGF-I they were more effective than single molecules in inducing aromatase expression. AAS exhibited estrogenic activity and induced rapid estrogen receptor (ER)-dependent pathways involving IGF1R, AKT and ERK1/2 phosphorylation. Inhibitors for these kinases decreased AAS-dependent aromatase expression. Up-regulated aromatase levels and related E2 production increased cell proliferation as a consequence of increased cyclin E expression. The observation that ER antagonist ICI182,*** was also able to significantly reduce ASS- and AAS + IGF-induced cell proliferation, confirmed a role for estrogens in AAS-dependent proliferative effects. Taken together these data clearly indicate that the use of high doses of AAS, as it occurs in doping practice, enhances Leydig cell proliferation, increasing the risk of tumor development. This risk is higher when AAS are used in association with IGF-I. To our knowledge this is the first report directly associating AAS and testicular cancer.

J. Cell. Physiol. © 2011 Wiley-Liss, Inc.

Copyright © 2011 Wiley-Liss, Inc.

PMID:21769864[PubMed - as supplied by publisher]

Both Nandrolone/Stanozolol both increase expression of leydig cell tumour proliferation, so if you fall into that category, dont use them.

Secondly, I'd also stay away from IGF-1, or anything that increases IGF-1 (various AAS, rHGH, various IGF analogues/peptides).

**yungone501** · 07-26-2011, 05:19 PM

What are the primary aas compounds (aside from those listed above) that increase igf1?

**Lemonada8** · 07-26-2011, 05:42 PM

^everyone of them in a anabolic dose. but IGF1 is very dependent on estrogen

That article kinda backs a general assumption that steroids increase tumor growth by putting it in a great environment to grow and proliferate. And being it binds to AR, ER down in the testes it will increase the ability of tumors to grow.

Awesome article find!

**dec11** · 07-26-2011, 06:05 PM

time for a nut check me thinks

**brad1986** · 07-26-2011, 06:09 PM

im going to go take a shower and grab at my sack now

**Bonaparte** · 07-26-2011, 07:01 PM

Meh, serious AAS users should be less concerned with testicular cancer than other men. After all, losing a testicle (or even both) wouldn't change anything for me besides esthetics, since they aren't doing shit anyway.

But yeah, the risk of it proliferating sucks, as would having to get the surgery.

**Swifto** · 07-27-2011, 03:58 AM

Originally Posted by Lemonada8

^everyone of them in a anabolic dose. but IGF1 is very dependent on estrogen

That article kinda backs a general assumption that steroids increase tumor growth by putting it in a great environment to grow and proliferate. And being it binds to AR, ER down in the testes it will increase the ability of tumors to grow.

Awesome article find!

Exactly my thoughts, the enviroment is far from optimal isnt it.

Agreed on AAS increasing IGF. Tren seems to increase IGF a fair deal from what I can remember.

**Swifto** · 07-27-2011, 04:00 AM

Originally Posted by Bonaparte

Meh, serious AAS users should be less concerned with testicular cancer than other men. After all, losing a testicle (or even both) wouldn't change anything for me besides esthetics, since they aren't doing shit anyway.

But yeah, the risk of it proliferating sucks, as would having to get the surgery.

Actually, I think its the opposite because of the enviroment steroid 's cause (Lemonada pointed out).

Spermatogenesis doesnt stop fully when on steroids , hence the reason why many steroid and bodybuilders get their gf's/wives pregnant on cycle.

CHECK YOUR BALLS!

**Vullfromsc** · 07-27-2011, 04:44 AM

so.. do i just check for lumps or what? lol

**Bonaparte** · 07-27-2011, 12:52 PM

Originally Posted by Swifto

Actually, I think its the opposite because of the enviroment steroid 's cause (Lemonada pointed out).

Spermatogenesis doesnt stop fully when on steroids , hence the reason why many steroid and bodybuilders get their gf's/wives pregnant on cycle.

CHECK YOUR BALLS!

Well yeah, but that was not my point at all.

While we are at a higher risk, most guys who are using enough gear to increase their chances of testicular cancer wouldn't have a problem getting them amputated and staying on test for life. Most guys I know couldn't imagine losing a testicle. I could have both of mine amputated and not bat an eye, since I can easily supply myself with TRT for life and I don't want kids anyway.

It wasn't a scientific observation, just an ironic comment.

**Stickman123** · 07-27-2011, 01:21 PM

Originally Posted by Bonaparte

Meh, serious AAS users should be less concerned with testicular cancer than other men. After all, losing a testicle (or even both) wouldn't change anything for me besides esthetics, since they aren't doing shit anyway.

But yeah, the risk of it proliferating sucks, as would having to get the surgery.

Right. The problem with cancer is that it will kill you. Try looking buff for the ladies when you're on your 10th "cycle" of chemotherapy.

**Hazard** · 07-27-2011, 02:56 PM

Originally Posted by Swifto

Exactly my thoughts, the enviroment is far from optimal isnt it.

Agreed on AAS increasing IGF. Tren seems to increase IGF a fair deal from what I can remember.

ahhhhh fvvvck

I'm sure you're right..... it probably plays a role in the fatloss noticed with tren . Tren also has the ability to build muscle tissue in a caloric deficit (Can't remember where I read that tho)

I was checked for testicular cancer a couple years ago. Had a mega swollen nut for no reason with a small lump. The ultrasound showed no tumors..... just blood.

I just recently decided to cut the tren out..... really want to try and stick with testosterone .

Thanks for the article swifto!

~Haz~

**Lemonada8** · 07-27-2011, 03:51 PM

Originally Posted by Stickman123

Right. The problem with cancer is that it will kill you. Try looking buff for the ladies when you're on your 10th "cycle" of chemotherapy.

a tumor doesnt mean its cancer. Its generically called cancer because it is serious, but it can be removed w/o much complications. lance armstrong for example had a tumor, it was removed and he won the Tour de france again...