Are AI's AAS dose dependant?

[Lemonada8]

Typically speaking, the dose of AI shouldnt change much with the dose: unless you are going to a very high Test level...

Remember, Test and Estrogen levels are a ratio in the body and the AI helps tip that balance into more "T" region by inhibiting aromatase therefore lowering the E production.
However, the major balances of estrogen on the body are due to 2 reasons: The balance between ER-α and ER-ß on certain organs ( prostate for example) which have opposing actions at the end organ(entirely within the organ/cell specificaly - so down to the pure cellular level - One acts to increase proliferation and action, and the other acts to inhibit proliferation and activation)
and the total amount of estrogen in the body. Testosterone doesnt have the reverse/inhibiting effects completely ( like the ER receptors do), it does have some of the opposing effects at the end organs, but since it doesnt have the opposing effect at the cellular level to actively compete with estrogen activation: the elevated levels of estrogen will increase their effects at the end organs which would get at the duality of receptor type.

So when one is using *absurdly high*(pure opinion there) amounts of test/week: there is much more test in the system which is converted to aromatase and kept in a ratio balance:
To put it mathematically - if 20% of T was converted to E... then 500mg/week T dosing would end with 100mg/week of E and 400mg/week of T. Then with the use of an AI which helps prevent ~10%, the E levels would end up being 50mg/week Estrogen and 450mg/week of T:
Now change that with a 1000mg/week: W/O an AI, keeping with a similar ratio.. would be 800mg/week of T and 200mg/week Estrogen: with the AI - 900mg/week of T and 100mg/week E. Now that much of an increase of Estrogen in the body would have more estrogenic effects ( ultimately depending on the individuals ER ratio on their cells: but still, flooding the ER receptors with that much estrogen; the proliferative effects will predominate resulting in increased estrogenic issues)

As you can see, the typical dose of AI wouldnt be sufficient because the ratio wouldnt be hampered enough to keep the estrogen levels suppressed enough to prevent negative manifestations because they are total amount related and not ratio-regulated.

[stevelifts]

[The Bear 79]

What is that supposed to mean?

[MickeyKnox]

Typically speaking, the dose of AI shouldnt change much with the dose: unless you are going to a very high Test level...

Remember, Test and Estrogen levels are a ratio in the body and the AI helps tip that balance into more "T" region by inhibiting aromatase therefore lowering the E production.
However, the major balances of estrogen on the body are due to 2 reasons: The balance between ER-α and ER-ß on certain organs ( prostate for example) which have opposing actions at the end organ(entirely within the organ/cell specificaly - so down to the pure cellular level - One acts to increase proliferation and action, and the other acts to inhibit proliferation and activation)
and the total amount of estrogen in the body. Testosterone doesnt have the reverse/inhibiting effects completely ( like the ER receptors do), it does have some of the opposing effects at the end organs, but since it doesnt have the opposing effect at the cellular level to actively compete with estrogen activation: the elevated levels of estrogen will increase their effects at the end organs which would get at the duality of receptor type.

So when one is using *absurdly high*(pure opinion there) amounts of test/week: there is much more test in the system which is converted to aromatase and kept in a ratio balance:
To put it mathematically - if 20% of T was converted to E... then 500mg/week T dosing would end with 100mg/week of E and 400mg/week of T. Then with the use of an AI which helps prevent ~10%, the E levels would end up being 50mg/week Estrogen and 450mg/week of T:
Now change that with a 1000mg/week: W/O an AI, keeping with a similar ratio.. would be 800mg/week of T and 200mg/week Estrogen: with the AI - 900mg/week of T and 100mg/week E. Now that much of an increase of Estrogen in the body would have more estrogenic effects ( ultimately depending on the individuals ER ratio on their cells: but still, flooding the ER receptors with that much estrogen; the proliferative effects will predominate resulting in increased estrogenic issues)

As you can see, the typical dose of AI wouldnt be sufficient because the ratio wouldnt be hampered enough to keep the estrogen levels suppressed enough to prevent negative manifestations because they are total amount related and not ratio-regulated.

This is an excellent answer bro! Do you have a link for any of this information? If so, i would like to read the article in its entirety.

Thanks!