Can we clear up the whole test/prostate thing? OASIS?

[Spyke]

I know we have touched on this before but it still makes no sense to me. Maybe if Oasis reads this they can get a doc to reply.

Everything you read about TRT talks about watching the prostate and kinda implies that it can cause prostate problems...

BUT

It makes no sense at all! I am taking test to raise my levels but they remain well within the "normal" range. Which means some guys my age actually produce that much test naturally....right? So why would I be at a higher risk then those guys? Our levels are the same. I just happen to shoot mine with a needle.

Now if they were talking about guys using AAS that may make some sense. They are raising their levels far beyond what any man could ever hope to produce naturally.

WTF?

[Ufa]

Spyke - aas do not cause cancer! However the do increase red blood cells.
If some one is prone to cancer or allready has cancer or a prostate problem
the increased red blood cells will make things worse. Cancer feeds off red blood cells.

[balin]

Test makes cells grow and divide. Sop if you have prostate cancer then the high levels of test can make the cancer grow quicker. That is the therory anyway.

[Oasis]

I appologize for the delay in posting a response with the relation to prostate cancer and testosterone replacement . Though most individual will probably find studies that will show the contrary each way I have found a few in the research that we have that may help shed some light on the subject. The Journal of Urology states the following in a study that was done in November 1997:

Abstract
Purpose
Parenteral testosterone supplementation is a common treatment for erectile dysfunction in hypogonadal men. Despite its frequent use, the effect of testosterone on prostate specific antigen (PSA) in these patients has not been documented previously. In this study we determined the effect of parenteral testosterone replacement on PSA and PSA velocity in a group of men being treated for erectile dysfunction.

Materials and Methods
A retrospective analysis of 48 patients (mean age 65.9) was performed and 2 study groups were identified. Group 1 consisted of 27 patients with a serum PSA level before and after initiating testosterone replacement therapy, and group 2 consisted of 27 men with a minimum of 3 PSA measurements (intervals of 6 months or greater) while on testosterone replacement. Each man had erectile dysfunction, a normal digital rectal examination and a low or low-normal total serum testosterone level before initiating therapy. Testosterone replacement was discontinued if no subjective improvement in erectile function was obtained, or if prostate adenocarcinoma was suggested by digital rectal examination or PSA.

Results
The mean increase in PSA after initiating testosterone replacement was 0.29 ng./ml. representing a mean change of 37% from baseline (mean interval 12.8 months). The mean PSA velocity was 0.05 ng./ml. per year. Pretreatment testosterone level, age and testosterone dose did not independently alter the PSA during testosterone replacement. Eleven men required prostate biopsies during treatment. Biopsies were indicated for abnormal digital rectal examination in 10 men and an elevated PSA in 1. All biopsies were benign.

Conclusions
Parenteral testosterone replacement in hypogonadal men with normal pretreatment digital rectal examination and serum PSA levels does not alter PSA or PSA velocity beyond established nontreatment norms. Thus, any significant increase in PSA or PSA velocity should not be attributed to testosterone replacement therapy and should be evaluated.

I hope this will help and I will be posting more studies as they become available. If you need the whole article please let me know and I can arrange getting you a copy.

Oasis Longevity & Rejuvenation Mngmt
1-877-548-3968
www.oasisrejuvenation.com

[Oasis]

Here is another one from the Journal of Urology Let me know if you need the full copy. I believe this study was not as strong due to the lack of subjects that participated.

Abstract
Purpose
We evaluated the effect of exogenous testosterone administration on serum total and free prostate specific antigen (PSA) in healthy young men.

Materials and Methods
Nine volunteers received either 100, 250 or 500 mg. testosterone by intramuscular injection each week for 15 weeks. Blood was drawn every other week for 28 weeks and at week 40. Serum total and free PSA, and total and free testosterone were measured and compared to baseline values.

Results
Significant elevations in total and free testosterone occurred but no significant change in serum total and free PSA was detected.

Conclusions
Serum PSA is not responsive to elevated serum testosterone levels in healthy young men. PSA metabolism in the normal prostate is unclear but our findings may have implications for differentiation of pathological conditions of the human prostate.

[Oasis]

Here is a study that is more recent than the others. Once again if you would like more information on this study please let me know but I have only copied the basic information of these studies for simplicity reasons.

December 2003 Journal of Urology:

ABSTRACT
Purpose
One of the greatest concerns among clinicians regarding testosterone replacement therapy (TRT) is the fear of causing or promoting prostate cancer. We evaluated prostatic changes in hypogonadal men with and without high grade prostatic intraepithelial neoplasia (PIN), which is considered a prostatic precancerous lesion, after 1 year of TRT.

Materials and Methods
A total of 75 hypogonadal who completed 12 months of TRT were studied. All underwent prostate biopsy prior to initiating treatment. Of the men 55 had benign prostate biopsies (PIN−) and 20 had PIN without frank cancer (PIN+). All men with PIN underwent repeat biopsy to exclude cancer prior to the initiation of testosterone treatment. Prostate specific antigen (PSA), and total and free testosterone were determined prior to treatment and at 1 year. Repeat biopsy was performed for a change noted on digital rectal examination or for a PSA increase of 1 ng/l or greater.

Results
PSA was similar at baseline in men with and without PIN (1.49 ± 1.1 and 1.53 ± 1.6 ng/dl, p >0.05) and after 12 months of TRT (1.82 ± 1.1 and 1.78 ± 1.6 ng/dl, respectively, p >0.05). A slight, similar increase in mean PSA was noted in the PIN− and PIN+ groups (0.25 ± 0.6 and 0.33 ± 0.6 ng/dl, p >0.05). One man in the PIN+ group had cancer after biopsy was performed due to abnormal digital rectal examination. Four additional men in the PIN− group and 2 in the PIN+ group underwent re-biopsy for elevated PSA and none had cancer. No differences were noted between the PIN− and PIN+ groups with regard to total and free testosterone at baseline and at 1 year (p = 0.267).

Conclusions
After 1 year of TRT men with PIN do not have a greater increase in PSA or a significantly increased risk of cancer than men without PIN. These results indicate that TRT is not contraindicated in men with a history of PIN.


Oasis Longevity & Rejuvenation Mngmt
1-877-548-3968
www.oasisrejuvenation.com

[zaggahamma]

thanks for catching up

[Spyke]

Great info Oasis! I dont know if I am more or less confused now. My concern is really for us younger guys. It does not sound like a guy who is on TRT for 30 years will be at a higher risk for prostate problems. The risk factors seem more genetic.

cbc, psa and test levels every 6 -8 months seems like a real quick and easy way to keep an eye on all this!

[scubadoo]

i think prostrate and HGH are more of an issue.. reason being is that HGH will make a tumor grow faster... growth hormone will make everything but you eyeballs grow.. even a tumor

can Oasis add to this please..

By the by i use Oasis and think they are GREAT

hey Jason... how the heck are ya?

[Ufa]

If you have a tumor you should get it cut out.

[scubadoo]

If you have a tumor you should get it cut out.

yes cut it out.. the problem is that if you dont get check enough.. by the time you go in for a reg check.. hgh will have made it grow too fast.. for normal diag and treatmnt.. so getting your prostate check more often is the safest way to go..

Having your girl friend with a medical degree and lic. makes if safer and FUN LMAO