pt-141

**tboney** · 04-20-2008, 07:24 PM

Does anyone have any experience with pt 141?

**Kale** · 04-21-2008, 08:39 AM

I have not, but for those that dont know what this is here is an explanation

Bremelanotide (formerly PT-141) is the generic term for a new medication for use in treating sexual dysfunction in men (erectile dysfunction or impotence) as well as sexual dysfunction in women (sexual arousal disorder). It is the only known synthetic aphrodisiac. Unlike Viagra and other related medications, it does not act upon the vascular system, but directly increases sexual desire. Bremelanotide is a spray introduced nasally.

Originally, the peptide Melanotan II that bremelanotide was developed from was tested as a sunless tanning agent. In initial testing, Melanotan II did induce tanning but additionally caused sexual arousal and spontaneous erections as unexpected side effects in nine out of the ten original male volunteer test subjects.[1] In clinical studies, bremelanotide has been shown to be effective in treating male sexual and erectile dysfunction as well as female sexual dysfunction. It is currently being tested by Palatin Technologies.

A Phase III clinical trial was scheduled to begin in the first half of 2007, but was delayed until August 2007. On August 30th, Palatin announced that the FDA had expressed serious concerns regarding the benefit/risk ratio of bremelanotide with regards to the side effect of increased blood pressure. The FDA also stated that they would consider alternate uses for bremelanotide, including as a treatment for individuals who do not respond to more established ED treatments.

**Teegunn** · 04-21-2008, 11:00 PM

Good info, Kale. I had no idea PT-141 (sounds like a german submarine huh) was derived from MT2. I know for a fact that MT2 will help sex drive. It does have a pretty noticeable flushing feeling though along with some upset stomach sometimes. You have to give to get I suppose.