Few AI questions

[meathead320]

Hi all,

Finally got that script for anastrozole few weeks ago, and things have been improving. Blood work scheduled in 5 more weeks. Hopefully whatever dose feels gbest is also keeping me in range.

Currently on:

60mg Test cyp 2x EW, both monday and thursday.

0.25mg anastrozole EOD

I know the general rule is 1mg of AI per 100mg of test, and my dose averages only 0.875mg EW for 1.2, BUT with the dose spilt up the peak level of 60 2x per week is the same as 100 1x per week. I am dosing off of what I think the peak level is around. http://www.steroidsource.net/calculator.htm

I do have a bit of gyno behind my left nipple. Its a small lump that cannot be seen, but it can be felt with my fingers. It is actually a bit painfull and sensitive to the touch.

I know the lump will not go away, and would need to be removed, but does the pain in it stop once the E2 is under control? If so about how long after starting the AI?

Ohh, one more question, does the absorption of anastrozole differ if taken on empty stomach vs. with food?

[Pheedno]

I would disagree with the dosing schedule(1mg/100mg). Dosing should be an individualistic thing.
The lump you have is possibly remedied by letrozole . I have had luck in shrinking a solidified lump with a letro/b6 combo. I doubt the anastrozole will do that. It sounds like it isn't to bad, though. If the anast is doing it's job you should have cesation of pain in the nipple.

Absorption is fine either way. I've seen a difference in a precontest setting when using a stronger AI for drying out but could have been placebo. For your purposes, no problem either way.

[THE-DET-OAK]

any AI is best with high fat meal. surprisingly there is a study floating around where they used adex to treat gyno, and it DID reduce in cases where nolva was unsuccessful, but everyone is different. your dose is a good dose to control E, may have to go higher to get reduction though, I think it was 1 mg ED in study. this was a study on hypo males on TRT

[bass]

i don't know about the pain, but it will help with sensitivity! i take my anastrozole on empty stomach with 16 oz water early morning, and it seems to take effect within 24 hours! you can take it with food i don't think it matters! as far as removing the bump behind your nipple, it should be very simple procedure, use the smart lipo where they use laser and ultrasonic technology, this will help tighten your skin as well! if my gyno (fat gyno) doesn't melt away i am definitely doing smart lipo!

http://www.smartlipo.com/smartlipovideos.html

[forrest_and_trees]

.25mg EOD is a good starting point but AI is pretty individualistic as everybody tends to aromatize at different rates based on a number of factors. It's best to start slow because overdoing it is a *real* drag. 1mg daily will tank your E2 and you'll feel like shite. In time, you'll get better at reading the signs and find you're own ideal dosage as you fine tune.

[NOSUPERMODEL]

i don't know about the pain, but it will help with sensitivity! i take my anastrozole on empty stomach with 16 oz water early morning, and it seems to take effect within 24 hours! you can take it with food i don't think it matters! as far as removing the bump behind your nipple, it should be very simple procedure, use the smart lipo where they use laser and ultrasonic technology, this will help tighten your skin as well! if my gyno (fat gyno) doesn't melt away i am definitely doing smart lipo!

http://www.smartlipo.com/smartlipovideos.html

What are the signs that it is taking effect that you notice. I take mine right before bed, so I go to sleep right after I take it. I am just wondering if I should switch up my times. But I want to know what kind of signs to be looking for.

[bass]

What are the signs that it is taking effect that you notice. I take mine right before bed, so I go to sleep right after I take it. I am just wondering if I should switch up my times. But I want to know what kind of signs to be looking for.

no signs, my clinic told me that, also based on my last experience, i was at 102 with my e2 and within one week i was down to 18! so i am assuming it didn't go down at the last minute, it went down gradually from the start! however its the opposite when you stop taking AI, it take about 2-3 weeks to lose the effect, and this is what my clinic told me also!

[steroid.com 1]

Starting out at 1mg / week at 120 mg of T is a pretty much the standard before labs to dial in. I also like that you're taking your AI EOD, really helps to keep consistent E2 levels. I just had labs done, and I am on the exact same protocol, and my E2 was 22.6 pg/ml...which delighted me to no end.

My Free T was 2.58% as well.

I'd buy that for a dollar:-)

[kjs1977]

don't know if im in the right place but has anyone ever used the prohormone emoster and if so what are your view on it

[kjs1977]

it's emonster sorry!

[steroid.com 1]

it's emonster sorry!

Start your own thread kjs; please don't hyjack this one with your question.

[bass]

Starting out at 1mg / week at 120 mg of T is a pretty much the standard before labs to dial in. I also like that you're taking your AI EOD, really helps to keep consistent E2 levels. I just had labs done, and I am on the exact same protocol, and my E2 was 22.6 pg/ml...which delighted me to no end.

My Free T was 2.58% as well.

I'd buy that for a dollar:-)

cool! i will be updating my thread as well but i like to say that going 1/2 mg Anastrozole eod three days a week is working great for me, currently am on 160 mgs T ew, not sure where my E2 levels are but may back muscle aches are going away and i am feeling much better! so i agree it seems that 1mg AI per 100 mgs of T is about right!

[steroid.com 1]

cool! i will be updating my thread as well but i like to say that going 1/2 mg Anastrozole eod three days a week is working great for me, currently am on 160 mgs T ew, not sure where my E2 levels are but may back muscle aches are going away and i am feeling much better! so i agree it seems that 1mg AI per 100 mgs of T is about right!

Glade to here things are working for you Bass. Keep us posted.

[meathead320]

Hi all,

One more Question on the AI's, as I am concidering to simplify things, going back to 1x EW, of 100mg.

For a couple reasons. The biggest being libido, and the other is just not to be injecting so much, and makes it easier to get out of town for a week at a time etc...

The libido reason is what this has all been ebout for me lately. I have noticed a big improvement on the 0.25mg arimidex with the 60mg 2x EW plan.

I do think things could be even better however, and I think that a small peak and valley, combined with E2 control would be ideal for all reasons including dopamine sensitivity etc...

I am pretty sure now that 0.25mg EOD of armidiex is keeping my E2 stable, but if I am injecting 1x EW, on every thursday, then would it be best to take the 0.25mg arimidex on thursday evening 12 hours after the test shot, so as to get it going around the time the testosterone hits its peak (hour 18), and then take the next dose on saturday, then monday, and then skip the wednesday shot as the testosterone would now be low enough that E2 conversion would not be an issue this day?

Here would be the Protocol:

Thursday: 8am 100mg Test Cypionate , 8pm 0.25mg Anastrozole
Saturday: 8am 0.25mg Anastrozole
Monday: 8am 0.25mg Anastrozole

So it would not be exactly EOD for the Anastrozole, as the wednesday dose would not be taken, and be pushed back to the next day, the day of the shot, as by wednesday itself the test level should be low enough not to need the AI anyway.

[bass]

i don't think it matters, adex will be in your system for days anyway, especially if you're taking it eod, i don't think one day will make any difference! according to my clinic adex stays in your system for 2-3 weeks, and it takes effect within 24 hours after taking it!

[meathead320]

Well then I think I will give this one a try. Very close to what I am doing, just going to have a slightly greater peak and valley in test levels, but in theory that little valley and peak may have a benefit. Not going to be like EOW injection peak and valley, but just going from top of the range to lower 1/3rd at the end day or two of it, which I'm ok with.

[zaggahamma]

i don't think it matters, adex will be in your system for days anyway, especially if you're taking it eod, i don't think one day will make any difference! according to my clinic adex stays in your system for 2-3 weeks, and it takes effect within 24 hours after taking it!

this is my take on AI use and experience

and to add when i feel nip sensitivity and take anastrazole that senstivity is gone shortly after taking .25 mg (couple hours)

[forrest_and_trees]

this is my take on AI use and experience

and to add when i feel nip sensitivity and take anastrazole that senstivity is gone shortly after taking .25 mg (couple hours)

Same here including; puffy nipples and irritability. They usually clear up within a couple hours of taking .25mg.

The signs I look for are:
- Sensitive nipples
- Tingling in my pectorals
- Puffy nipples
- Irritable or emotional for no reason
- Water retention. i.e. not pissing much, general puffiness around the face, hands and ankles etc.

The water seems to take the longest to respond. There are times I can drink a gallon of water and never have to piss, but when I get my E2 dialed in, I'm pissing all the time, several times a day. Sometimes like every hour depending on how much fluid I'm taking in.

[meathead320]

Funny you guys mention the water retention.

Soon as I got on the Adex, people commented on "I can see how much weight you've lost in your face!" They thought I had cut like 20 pounds.

More like peed it out.

[forrest_and_trees]

Ya, no kidding. I'd lost 60 lbs. and hardly anyone said a thing, then I started hitting the anastrozole hard, because I began taking HCG and added DHEA back do my regimen, and *now* people notice. LOL. Life is full of ironies.

[Bigfoot66]

I follow the same dosage of AI. I take 200 mg wily broken into 2 doses. I take bloodtest Wednesday so I'll know levels but as I said before you eventually can tell when levels are right because you just feel right....can't explain but it is easier and easier to know rue in sync.

cool! i will be updating my thread as well but i like to say that going 1/2 mg Anastrozole eod three days a week is working great for me, currently am on 160 mgs T ew, not sure where my E2 levels are but may back muscle aches are going away and i am feeling much better! so i agree it seems that 1mg AI per 100 mgs of T is about right!

[meathead320]

One more question just came up. If I drive my E2 too low, as in took 0.5mg the other day, and noticing stiff joints, suddenly really bad unable to get or maintain and erection / and low libido... How long does it generally take for the E2 levels to climb back up?

Is it a very quick, wam! and the E2 levels will be too high again? Or do they slowly climb back up, even passing through the "sweet spot" where I should feel good, and be waking with strong morning wood for a couple days?

What I'm trying to do is find what dose makes me feel the best, before I get my blood tested, so the test will let me know what blood levels are best for me. Either way Blood test is coming soon, so if I have not dialed it in right by then, it will be an indicator of which way to dose.

Things had improved on 0.25mg EOD, but still felt like it could be better, so I tried 0.5mg for one of those, and it clearly seems to have been too much.

I may even try 0.25mg 2x EW, roughly E3D and see how that feels, but want to wait until my E2 comes up a bit, which it has not quite done yet.

If moving the dose up from X makes a problem worse, then perhaps slightly less than X is better?

[GotNoBlueMilk]

Anastrozole has a half-life of 2-3 days. So, going with 2 days, that means half of the dose is out of your blood in 2 days. 3/4 of the dose is gone in 4 days, 7/8 gone in 8 days, etc. As the blood serum levels decrease, E rises.

Skip a dose, then go back to dosing.

I inject my T twice a week. I also take my AI twice a week, on the days I inject. This gets the AI at the highest concentrations at the same time my T is at the highest concentrations. And as my T lowers, my AI gets lower.

If you inject once a week, maybe you can do a slightly higher AI does on that day, and then back off some on subsequent doeses. Just a thought.

[meathead320]

Thanks again,

Ok, so here is the revised strategy then:

100mg Test Cype 1x EW Thursday
0.25mg Anastrozole Thursday
0.25mg Anastrozole Sunday

By wednesday my Test level should be at its lowest, also when the Anastrozole should be at its lowest too.

Will keep on this until blood test. Talk with Doc then too. If I'm still not feeling right libido wise we should see why on the labs, E2, prolactin, Test, Free test etc... Adjust doses from there.

[bass]

i agree with GNBM, i take .5 mgs AI eod but also take it the day i inject! but of course i keep clanging it based on how i feel!

Sunday, inject 160mgs test plus .5 AI
Monday, .5 AI
Tues, skip
Wednesday, .5 AI
Thursday, skip
Friday, .5 AI
Saturday, Skip

so far it seems to be the best dose and frequency!

[bass]

Thanks again,

Ok, so here is the revised strategy then:

100mg Test Cype 1x EW Thursday
0.25mg Anastrozole Thursday
0.25mg Anastrozole Sunday

By wednesday my Test level should be at its lowest, also when the Anastrozole should be at its lowest too.

Will keep on this until blood test. Talk with Doc then too. If I'm still not feeling right libido wise we should see why on the labs, E2, prolactin, Test, Free test etc... Adjust doses from there.

it maybe too low of a dose for the AI, but everyone is different! give it shot and see what happens!

[Bigfoot66]

I take eod but never thought about on day of injection as well. Good idea!

i agree with GNBM, i take .5 mgs AI eod but also take it the day i inject! but of course i keep clanging it based on how i feel!

Sunday, inject 160mgs test plus .5 AI
Monday, .5 AI
Tues, skip
Wednesday, .5 AI
Thursday, skip
Friday, .5 AI
Saturday, Skip

so far it seems to be the best dose and frequency!

[steroid.com 1]

I inject my T twice a week. I also take my AI twice a week, on the days I inject. This gets the AI at the highest concentrations at the same time my T is at the highest concentrations. And as my T lowers, my AI gets lower.

Personally, I am a big proponent of this type of protocol. It provides for more even T and E2 levels (more natural) and helps to make men feel better more consistently. No ups and down. All men are different and long esters can make once a week work...but that being said, there's enough out there to support this protocol. In fact a E3D protocol may be even better!

[forrest_and_trees]

I too had the same result taking .50 mg, stiff, ache, popping joints, no wood, low libido. Yes... I did climb back up after a day or so and did hit the sweet spot on the way, but then overshot the mark, took .50 again and crashed again. It was a friggin roller coaster drag. I've since gone to .25 as needed and no more crashes. As I mentioned above, since adding HCG and DHEA, I now take much more often, some times every day, but still no crashes.

[meathead320]

Yeah, I've heard HCG and DHEA can do that. I don't take either.

As for the HCG, my issue was primary hypogonadism. Testes themselves just not able to do much, have frozen sperm at a cryolab, so fertility is a non issue anyway.

Might talk to my urologist about the DHEA, if it really helps libido, and if mine is low then for sure. Until then I only like to adjust one thing at a time.

The anastrozole has helped a lot already, when I don't overshoot, but as for now I still think there is room for some improvment.

I want that fire back, like that sometimes feeling so horny the heart is pounding, craving it must have now feeling. I miss that.

These days its more like "sex, well yeah, it feels good, I'd could go for some".

From most people I've read posting here, once E2 is in balance, if the test is high enough its quite easy to be in that agressive horny mood, and it seems to have more to do with the E2 being right than anything.

I figure that has a lot to do with when E2 getting really high it raises prolactin.