Cialis and BPH

[JD250]

FDA Approves Cialis to Treat Benign Prostatic Hyperplasia
October 6, 2011 -- The U.S. Food and Drug Administration today approved Cialis (tadalafil) to treat the signs and symptoms of benign prostatic hyperplasia (BPH), a condition in which theprostate gland becomes enlarged, and for the treatment of BPH and erectile dysfunction (ED), when the conditions occur simultaneously. Cialis was approved in 2003 for the treatment of ED.


Cialis should not be used in patients taking nitrates, for example nitroglycerin, because the combination can cause an unsafe decrease in blood pressure. Also, the use of Cialis in combination with alpha blockers for the treatment of BPH is not recommended because the combination has not been adequately studied for the treatment of BPH, and there is a risk of lowering blood pressure.


My question is this......I have, for quite some time, taken Saw Palmetto daily just to keep everything working well, I just started taking a maintenance dose of cialis (great pumps, in the gym and the bedroom)......should I stop taking the palmetto? could it be dangerous for blood pressure like an alpha blocker when mixed with cialis?

[steroid.com 1]

FDA Approves Cialis to Treat Benign Prostatic Hyperplasia
October 6, 2011 -- The U.S. Food and Drug Administration today approved Cialis (tadalafil) to treat the signs and symptoms of benign prostatic hyperplasia (BPH), a condition in which theprostate gland becomes enlarged, and for the treatment of BPH and erectile dysfunction (ED), when the conditions occur simultaneously. Cialis was approved in 2003 for the treatment of ED.


Cialis should not be used in patients taking nitrates, for example nitroglycerin, because the combination can cause an unsafe decrease in blood pressure. Also, the use of Cialis in combination with alpha blockers for the treatment of BPH is not recommended because the combination has not been adequately studied for the treatment of BPH, and there is a risk of lowering blood pressure.


My question is this......I have, for quite some time, taken Saw Palmetto daily just to keep everything working well, I just started taking a maintenance dose of cialis (great pumps, in the gym and the bedroom)......should I stop taking the palmetto? could it be dangerous for blood pressure like an alpha blocker when mixed with cialis?

I wouldn't really worry about it. If you don't present with any neg sides I think you're fine.

BTW, I take 5 mg of Cialis a day and think it's probably as important to my health at my TRT protocol. Love the stuff...

[marcus300]

Ive recently read this about cialis, thanks for posting.

Sounds like its an all round great supp

[NOSUPERMODEL]

My wife loves it. LOL!!!!!

[steroid.com 1]

There are tons of studies on the effective use of low dose Cialis (Tadalafil) for men. Not only is it a great blood pressure pharmaceutic but it decreases BPH, increases NO and inhibits PDE5 enzymes. It's a great drug for so many reasons and can be bought online pretty easily...go generic if you do. See conclusions below...

Abstract

OBJECTIVE:

To evaluate the effects of daily medication of low-dose tadalafil on the improvement of endothelial function and erectile hardness in erectile dysfunction (ED) patients.

METHODS:

A total of 60 ED patients and 24 controls were treated with oral tadalafil at 5 mg/d for 6 - 8 weeks, and evaluated by international index of erectile function-5 (IIEF-5), erectile hardness grading scale (EHGS) and brachial artery flow-mediated dilation (FMD) test before and after the treatment. All the data obtained were analyzed by independent-sample and paired-sample t tests, respectively.

RESULTS:

The treatment and follow-up were accomplished in 51 of the ED cases. Compared with the controls, the ED patients showed significantly lower scores on IIEF-5 (23.6 +/- 1.0 vs 10.3 +/- 4.5, P < 0.01), EHGS (3.7 +/- 0.5 vs 2.0 +/- 0.6, P < 0.01) and FMD (14.1 +/- 2.1 vs 8.1 +/- 1, P < 0.01). Daily medication of tadalafil achieved an effectiveness rate of 96.1% (49/51) in the treatment of the ED patients, and significantly improved their scores on IIEF-5 (16.9 +/- 3.9 vs 10.6 +/- 4.5, P < 0.01), EHGS (2.6 +/- 0.7 vs 2.0 +/- 0.6, P < 0.01) and FMD (9.2 +/- 1.7 vs 8.1 +/- 0.9, P < 0.01), as compared with pretreatment.

CONCLUSION:

Long-term daily medication of low-dose tadalafil can significantly improve endothelial function and erectile hardness of ED patients.


Abstract

BACKGROUND:

To assess the measurement properties of the Benign Prostatic Hyperplasia Impact Index (BII) for use in men with Lower Urinary Tract Symptoms (LUTS) secondary to Benign Prostatic Hyperplasia (BPH) treated with tadalafil.

METHODS:

Data from a dose-titration (Study 1) and a dose-finding placebo-controlled (Study 2) tadalafil studies of men 45 years of age or older with moderate to severe LUTS (N = 281; N = 1053) were included in this post-hoc analysis. Measures included the BII, International Prostate Symptom Score (IPSS), IPSS Quality of Life Index (IPSS-QoL), LUTS Global Assessment Question, uroflowmetry measure peak flow rate (Qmax) and postvoid residual volume (PVR). Spearman rank and Pearson correlation coefficients were computed between the BII score and the other measures at each visit. Wilcoxin two-sample tests, t-tests and general linear modeling compared BII scores of subjects with global ratings of improvement versus no improvement, and subjects taking tadalafil versus placebo. Effect size, standardized response mean and Guyatt's responsiveness statistic were calculated for BII and IPSS change scores.

RESULTS:

There were high correlations between BII and IPSS & IPSS-QoL and low correlations between BII and Qmax & PVR at each visit. There were significant differences in BII at the End-of-Study Visit between subjects reporting improvement versus subjects reporting no improvement (Studies 1 and 2, P < .0001) and subjects taking tadalafil versus subjects taking placebo (Study 1, P = .0045; Study 2, P = .0064). The BII and IPSS were both responsive to change.

CONCLUSIONS:

Results show that the BII is reliable, shows responsiveness to change in patients with BPH-LUTS, and demonstrates construct validity.

Abstract

INTRODUCTION:

Several phosphodiesterase type 5 (PDE5) inhibitors are commercially available for the treatment of erectile dysfunction (ED). Development of the first once-daily alternative dosing regimen with a PDE5 inhibitor was motivated by the behavioral complexities associated with sexual intimacy.

AIM:

To provide an alternative dosing option for certain men who may benefit from the removal of the temporal linkage between administration of an ED therapy and sexual intimacy or for men and their partners who anticipate at least twice-weekly sexual activity.

METHODS:

Pharmacokinetic predictions of tadalafil plasma concentrations were generated based upon empirical data following 20-mg, single-dose administration coupled with tadalafil usage patterns from as-needed clinical trials. To support the pharmacokinetic simulations and pharmacodynamic assumptions, clinical trials were conducted to demonstrate the efficacy and safety of once-daily, low-dose tadalafil 2.5 and 5 mg.

MAIN OUTCOME MEASURES:

Simulated tadalafil plasma concentrations and comparison with safety and efficacy measures from clinical trials.

RESULTS:

Based upon pharmacodynamic and pharmacokinetic data, once-daily doses of tadalafil 5 mg were predicted to provide therapeutic concentrations that would be maintained throughout the 24-hour dosing interval. Additionally, for a subgroup of men who anticipate at least twice-weekly sexual activity and are currently taking tadalafil 20 mg, a reduction in daily tadalafil exposure was predicted. To support the hypothesis that low-dose, once-daily tadalafil may be a safe and effective treatment alternative, clinical trials were conducted to demonstrate the safety and efficacy of once-daily tadalafil 2.5 and 5 mg. These results were similar to those of historical as-needed studies evaluating tadalafil 10 and 20 mg.

CONCLUSIONS:

Consistent with pharmacokinetic predictions, data from clinical trials indicate that once-daily use of low-dose tadalafil is a safe and effective treatment for men with ED.

[JD250]

My wife loves it. LOL!!!!!

You shouldn't let your wife take it.

I have no scientific data to back anything up but I swear I feel better after I lift now and pumped too, I could be all wet, maybe placebo, something is different since I started using this stuff..........and no I'm not referring to my wiener being enormous, it's always been that way.

[steroid.com 1]

You shouldn't let your wife take it.

I have no scientific data to back anything up but I swear I feel better after I lift now and pumped too, I could be all wet, maybe placebo, something is different since I started using this stuff..........and no I'm not referring to my wiener being enormous, it's always been that way.

It increases Nitric Oxide (see all the sports supplements claiming to do the same thing) so it's not a placebo effect...it's real. I get the exact same thing JD.

[APIs]

With this FDA approval, Insurance Pharmacy Plans will now accept Cialis scripts, as long as your Doctor makes the required diagnosis. I don't think any other ED med is widely covered at the moment...

[ecsaaron]

How is the cost of the daily dose vs the 30mg?

[sirupate]

Interested to have an idea of cost on the daily dose of Cialis. My doctor recently wrote me for 10mg. dose and I went to fill that at the local pharmacy. First I asked to fill the 10 dose scrip off of my insurance as I felt my insurance would not pay for 10 doses. Was shocked when the pharmacist quoted over $200 for 10 tablets. She then checked my insurance amount and they would fill 6 tablets for $25 every 6 weeks....so one tablet being allowed per week. Went with the insurance on that.

Gonna miss AR-R for their liquid Cia. Have not tried the Cialis tablet yet to know if it is any different from the liquid Cia version.

[Vettester]

Gonna miss AR-R for their liquid Cia. Have not tried the Cialis tablet yet to know if it is any different from the liquid Cia version.

Agreed, that was a nice compliment to the AR-R mix. However, it does appear to be available with the other research chem company that members are suggesting for their AI, SERMS, and peptides in general. Will PM you the info if you want.

[sirupate]

Agreed, that was a nice compliment to the AR-R mix. However, it does appear to be available with the other research chem company that members are suggesting for their AI, SERMS, and peptides in general. Will PM you the info if you want.

Yes, please do PM me with the information. Thanks.

[lvs]

Approximately $116 for 30 5mg tablets for daily use from CVS. They have a free 30-day trial program for daily use tabs.

Interested to have an idea of cost on the daily dose of Cialis. My doctor recently wrote me for 10mg. dose and I went to fill that at the local pharmacy. First I asked to fill the 10 dose scrip off of my insurance as I felt my insurance would not pay for 10 doses. Was shocked when the pharmacist quoted over $200 for 10 tablets. She then checked my insurance amount and they would fill 6 tablets for $25 every 6 weeks....so one tablet being allowed per week. Went with the insurance on that.

Gonna miss AR-R for their liquid Cia. Have not tried the Cialis tablet yet to know if it is any different from the liquid Cia version.

[JD250]

There are other (out of pocket) sources for much less......google it my bros, when you search a site use the name (tadalafil)

[lvs]

JD, are they generics? If so, do you feel they are the same?

There are other (out of pocket) sources for much less......google it my bros, when you search a site use the name (tadalafil)

[steroid.com 1]

I get mine online sourced over seas and they are legit.

Generic 10 mg (I split them into two 5 mg) at 60 pills for $116 = 4 months supply...well almost 4 months...some weekends I kick-up the dose for a little more fun

There are a number of online legit pharmacies where you can order. If you don't have a scrip they will provide the medical questionnaire and phone consult with MD for approval.

Cheap and easy to be honest fellows.

[JD250]

Yes and yes, I'm using ar-r stuff now but that wont be possible anymore, I'm not sure what the board rules are any more for this forum concerning this conversation but I do know there are some places to get it, shipping may be a little more from places like India.

[lvs]

Thanks GD and JD. Maybe now I can get PMs. gd if you could pm your source for this I would appreciate it.

[steroid.com 1]

Thanks GD and JD. Maybe now I can get PMs. gd if you could pm your source for this I would appreciate it.

Done. Let me know how it works out for you.

Shouldn't be a problem lvs.

Happy to help you my friend!