Reverse Brain Cell Death by Growing New Mitochondria

[Times Roman]

http://www.lef.org/magazine/mag2011/...hondria_01.htm

By Michelle Flagg

Go to Google and enter “mitochondria” and “neurodegeneration.” You’ll find hundreds of published studies linking the two.

The decay of mitochondria in brain cells is a primary cause of all neurodegenerative disorders, from Parkinson’s to dementia.1,2

This deadly process begins when free radicals inflict damage to nerve cells. But increased antioxidant intake by itself is not enough to halt this degenerative cascade. As one team of scientists stated in a study published in July 2011:

“Once the mitochondria are destabilized, cells are destined to commit suicide. Therefore, antioxidative agents alone are not sufficient to protect neuronal loss in many neurodegenerative diseases.”1

The encouraging news is that a novel strategy exists to replenish aging cells by triggering them to grow new mitochondria. The result is that many disorders related to brain aging may be halted and reversed.

In this article, you will discover how a compound called pyrrolo-quinoline quinone or PQQ triggers aging cells to grow new mitochondria.3 This process, called mitochondrial biogenesis, can prevent age-related cell death that accelerates brain degeneration.

You will also find evidence of PQQ’s power to stimulate nerve growth factor, combat stroke, Alzheimer’s, and Parkinson’s, and speed regeneration of damaged nerve cells.4-9

Mitochondrial Decay and Brain Degeneration
Every human cell contains tiny “organelles” called mitochondria that are essential to life itself. Mitochondria efficiently convert our intake of food and oxygen into clean energy.

Because of their constant exposure to high levels of energy and oxygen, mitochondria are especially vulnerable to damage by oxidative stress.10 With time, they lose their ability to efficiently manage energy transfer through the flow of electrons.11-13 As they become increasingly inefficient, mitochondria accumulate structural and functional damage, which then leads to a vicious cycle of further inefficiency and damage.14-16 Oxidative mitochondrial decay is now recognized as a major contributor to aging.17

It is now clear that the brain is a primary target of mitochondrial aging.13,18 As one of the body’s greatest consumers of energy and oxygen, the brain is an organ that is highly vulnerable to mitochondrial decay.19-22 That decay is evident in brain tissue as a selective loss of brain cells in areas associated with mobility and with learning and memory, which is why those functions deteriorate most rapidly with aging.17,19

In neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease, mitochondrial dysfunction is associated with abnormal brain cell activity and accumulation of toxic proteins.16,23,24 Older individuals who suffer strokes, with their impaired brain cell mitochondrial function, have more brain tissue injury and slower, less complete recovery than younger stroke victims.25

Even in apparently healthy older people, free of neurodegenerative diseases and strokes, mitochondrial dysfunction in brain cells leaves them with precious little reserve. Evidence strongly suggests that, while aged neurons can function adequately during normal activity, they quickly become vulnerable to the other metabolic stresses of aging.19 That’s why a minor illness or minimal trauma can so suddenly lead to massive—and irreversible—loss of cognitive function in an older adult.

There is now solid evidence that if we can prevent mitochondrial decay, or if we can reverse it by stimulating production of new mitochondria, we can slow down the aging process itself.17 And just as the brain is a principal target of mitochondrial aging, studies suggest that it also may be a main beneficiary of this “mitochondrial medicine” approach.11,24 That’s why mitochondria-targeted therapies are now captivating specialists in brain aging, cognition, and neurodegenerative diseases.24,26

As it turns out, PQQ provides impressive mitochondria-targeted therapy. Let’s examine the compelling evidence for PQQ’s direct neuroprotective effects in greater detail, in order to understand how supplementing with PQQ can prevent your brain from aging too rapidly.

The Science Behind PQQ’s Brain Anti-Aging Benefits
The most notable ways in which PQQ protects the brain from aging are related to its powerful redox cycling abilities. By far the most robust of the redox cyclers available (either as medications or as nutrients), PQQ potently blunts the deadly effects of reactive oxygen species (ROS) in brain tissue, thereby helping to keep existing mitochondria intact.27,28 There’s strong evidence that PQQ also scavenges existing reactive oxygen species,29,30 which offers further promise in reducing the oxidant load on brain mitochondria.

PQQ also stimulates the brain to produce healthy new mitochondria in the process known as mitochondrial biogenesis.3 Mitochondrial biogenesis is a powerful natural response to declining mitochondrial function.31 The use of “mitochondrial nutrients” such as PQQ that stimulate biogenesis may represent an important stride in preserving youthful brain function.32

But PQQ also exerts two additional effects that add to its already-impressive oxidant protection and mitochondrial preservation.
PQQ stimulates natural production of nerve growth factor (NGF)4,5 which triggers growth and branching of nerve cells.33 Nerve growth factor is vital in repairing damage caused by a stroke, by ischemia (loss of blood flow), or by an injury. In other words, PQQ shows promise in stimulating brain and nerve tissue to heal itself.34 That’s important both for people who’ve suffered overt injuries (from trauma or strokes), and also for those who’ve suffered the more subtle damage that can lead to so-called multi-infarct dementia.35-38

Treatment with PQQ reduces the impact of excitotoxicity in brain cells.39,40 Excitotoxicity occurs when neurons become electrically or chemically over-stimulated. It is one of the underlying causes of many age-related states of cognitive impairment, including Alzheimer’s and Parkinson’s diseases. Excitotoxicity is also associated with certain forms of epilepsy.41

PQQ’s powerful redox cycling abilities help it to chemically modify receptors for the most potent excitotoxic neurotransmitter, known as NMDA (N-Methyl-D-aspartic acid).42 Under the influence of PQQ, the NMDA receptors literally “quiet down” and stop producing the toxic effects that lead to neuronal dysfunction.6,43-45 In related actions, PQQ protects against environmental neurotoxicity as well, as in the case of deadly mercury poisoning.46

What You Need to Know: PQQ and Mitochondria
•Loss of mitochondrial function is now known to be a chief cause of aging in human tissues.

•That loss is especially profound in brain cells, which suffer a disproportionate exposure to the oxidative stress that damages mitochondria.
•The result is an unnecessary—and preventable—acceleration of brain aging.
•An ancient mitochondrial nutrient, PQQ, which is common to many living things, has recently been produced in meaningful quantities, thanks to a new process originating in Japan.
•PQQ protects and restores age-related mitochondrial function, and even increases the number of mitochondria in your tissues.
•PQQ offers proven neuroprotection by combating mitochondrial dysfunction in brain and peripheral nerve cells.
•PQQ’s unique actions offer hope in prevention of age-related cognitive decline, stroke-related neurological deficits, and neurodegenerative diseases
•PQQ also offers cardioprotection and enhanced immune function, both of vital concern in increasing longevity.


Powerful and Proven Neuroprotection
PQQ’s neuroprotection in the laboratory translates into impressive prevention of age-related cognitive deficits. Here are the compelling data:

Strokes are the third leading cause of death in older Americans, killing nearly 136,000 of us annually, and six million Americans live with the debilitating after-effects of a stroke.47 PQQ treatment of stroke in an animal study produced a significant reduction in size of the damaged brain area compared with control treatment—even when given after the stroke was induced.6 Another animal study demonstrated significant improvements in neurobehavioral scores following PQQ supplementation after a stroke.48

Cognitive decline caused by Alzheimer’s and Parkinson’s diseases robs hundreds of thousands of older Americans of joy and satisfaction in life each year. PQQ protects brain cells from two deadly proteins called beta-amyloid and alpha-synuclein that trigger those conditions.7,8 The result is that fewer brain cells die, and brain function is preserved, brightening the outlook for sufferers of these devastating diseases.7

Cognitive decline frequently occurs even in the absence of a diagnosed neurodegenerative condition or a stroke. Recent studies from Japan, where PQQ science is most advanced, show that a PQQ-supplemented diet improves learning ability in healthy animals.49 When the animals were subjected to 48 hours of extreme oxidant stress to mimic accelerated aging, the PQQ-supplemented group showed better memory function than the control group, and that improvement was sustained long after the stress.

In a similar study, aged animals (like many aging humans) demonstrated very poor learning ability at baseline.50 When supplemented with PQQ, however, the old individuals learned to navigate a maze with ease and retained their knowledge over time much better than did untreated animals, which showed a memory loss of about 60%.

PQQ’s neuronal benefits are not limited to cognitive factors, however. They also apply to other common age-related problems such as seizures and peripheral nerve injury.

Seizures occur with increasing frequency as our brains age and can be responsible for physical injury as well as neurological deficits.51 By combating the seizure-inducing excitatory effects of the NMDA neurotransmitter, PQQ suppresses spontaneous seizure activity and shortens duration of chemically induced seizures in animals.41 Importantly, PQQ achieves this effect without inhibiting normal NMDA receptor performance or baseline behavior.41

Damage to spinal and peripheral nerves causes substantial loss of function in older adults, the result of major or minor trauma and bony degeneration of the spinal column. Such functional losses lead to decreased mobility, impaired bowel and bladder function, loss of sexual enjoyment, and early death from complications.52,53 Dramatic results have been achieved in animals that capitalize on PQQ’s stimulation of nerve growth factor production and secretion. PQQ-induced nerve growth factor stimulation accelerates growth of cells that produce nerve cells’ vital insulating sheaths and speeds natural repair of damaged nerves.9 In one study, a one-centimeter gap in the sciatic nerve underwent rapid healing after treatment with PQQ, demonstrating improved nerve conduction velocity, strength of the nerve impulse, and increased numbers of nerve cells inside the sheath.9

PQQ: From Stardust to Stellar Mitochondrial Protection
PQQ was discovered only three decades ago,60,61 but its origins seem to be as old as the universe itself. A powerful and essential component of energy-transfer processes in a diverse range of living cells, PQQ is an advanced organic molecule that scientists believe they have identified in stardust collected from comets passing through our solar system.27,62,63

PQQ’s widespread presence in living matter and its ancient origins in the cosmos has intrigued scientists and stimulated massive amounts of research. Fueling this research is the recent discovery of a process for readily producing PQQ by natural bacterial fermentation.64-68 Scientific work since has revealed that PQQ functions as an essential human nutrient—a new vitamin, according to eminent researchers.39,69,70

PQQ stimulates growth and development in living things from bacteria to higher mammals.27,71 In mammals (including humans), PQQ directly modulates and slows mitochondrial aging.27,72

Studies have shown that animals deficient in PQQ develop many of the typical signs of aging: slowed tissue growth, poor reproductive function, impaired skin, bone, and connective tissue integrity, weakened immune systems, and most notably, impaired cognition.27,59,73,74 When PQQ is restored, those abnormalities are reversed.27,72,74

PQQ acts in living cells as a “redox cycler,” meaning that it modulates the flow of electrons that determine if a given chemical reaction produces oxidation or its opposite, known as reduction (hence “red-ox”).39,69 Redox cyclers are essential for protecting mitochondria from the vicious attacks of reactive oxygen species (ROS) generated during energy transfer activities.27,39

Many beneficial antioxidant nutrients, such as quercetin, green tea extracts, and vitamin C, are technically redox cyclers and thereby offer some mitochondrial protection.27 But PQQ is tremendously more robust. A single PQQ molecule can undergo more than 20,000 cycles of oxidation/reduction before it is destroyed, while more conventional redox cyclers give out after at most about 800 cycles.27

That incredible potency gives PQQ a tremendous advantage as a mitochondrial protector. In bacterial cultures in the laboratory, it requires only picogram quantities (one-trillionth of a gram) to support healthy growth and reproductive parameters.71

It’s clear that PQQ protects mitochondria, and that in doing so it protects brain cells from the ravages of mitochondrial aging, with all the deficits that entails.


Improving Immunity and Cardiovascular Health
PQQ’s remarkable anti-aging benefits are not restricted to the brain. Emerging science is demonstrating remarkable effects on two other systems vital to your longevity: the heart and the immune system.

Mitochondria make up an astonishing one-third of the mass of the human heart.54 Reliable quality control of cardiac mitochondria is therefore a major new target in preventing heart disease.55 PQQ is a highly effective cardioprotective agent as a result of its free radical scavenging and mitochondrial protecting characteristics.56,57

PQQ treatment either before or after experimentally induced heart attacks in animal models has multiple beneficial effects. PQQ reduced the size of the damaged (infarcted) area of heart muscle, resulting in a desirable increase in pumping pressure from the left ventricle.56 Treatment also reduced the number of episodes of ventricular fibrillation, a common and deadly complication of heart attacks. In a related study, PQQ performed as well as the prescription heart medication metoprolol in reducing infarct size. And PQQ proved superior to metoprolol in protecting mitochondria from oxidative damage arising from the infarction.58

Immune system cells rely heavily on adequate supplies of PQQ for normal function.27 That’s especially important for older people, in whom immune function reliably falls off with increasing age. PQQ deficiency produces defects in multiple branches of the immune system, impairing its ability to respond to invading stimuli and raising the risk of infection.27,59 A human equivalent dose of as little as 100-400 micrograms of PQQ per day maximizes sensitivity of important B- and T-lymphocytes (infection-fighting white blood cells) to external stimuli.27

Summary
Loss of mitochondrial function is both a cause and a consequence of aging, producing a vicious cycle of oxidative damage that destroys brain cells. While antioxidant intake is critical, researchers now recognize it as only one part of a comprehensive preventive strategy.

The nutrient PQQ, essential for many forms of life on Earth, comprises a powerful strategy to combat brain aging. PQQ protects mitochondria from cumulative oxidative damage and stimulates growth of healthy new mitochondria, thereby restoring youthful brain cell function.

PQQ’s effects on brain mitochondria, coupled with its other beneficial neuroprotective characteristics, make it a natural solution for preserving brain function as you age. Taken together with PQQ’s recently discovered cardioprotection and well-established immune enhancement, there is every reason to include PQQ in your supplement program.

[Times Roman]

go to the link and at the bottom, all references are posted

[yannick35]

I am on oxygen therapy using 8-10 drops of H202 hydrogen peroxide 35% food grade, this stuff kills nearly all pathogens in the body.

http://www.earthclinic.com/Remedies/..._peroxide.html

[Times Roman]

I am on oxygen therapy using 8-10 drops of H202 hydrogen peroxide 35% food grade, this stuff kills nearly all pathogens in the body.

http://www.earthclinic.com/Remedies/..._peroxide.html

Sounds like pseudo science to me. Once the bubbles are through, all you have is H2O. So how does oxygen coming out of solution in your gut "kills nearly all pathogens in the body"?

Do you have a link or can you show me a clinical study that will support your claim?

Some people claim that enemas and chanting do the same thing, but without any clinical data to support such a claim, it is only pseudo science.

Sorry mate

[yannick35]

Agree i was skeptic too after using it for 6 months and not being sick that kind of changed my mind.

http://dochand.wordpress.com/categor...oxide-therapy/

The medical community and pharmaceutical have no money to make with H202 its so cheap cost pennies a day, and is not a drug. They will say its dangerous to the body, will cause stomach to melt and dumb stuff like that. Its the same as dropping H202 on your finger, it will turn white and bubble, this is oxygen being released. It as the same effect in the body but must be diluted with distilled water.

I love earth clinic, there are lots of home remedies on there that science will say are worthless but its because there is no money to be made. My medical doctor put me on black strap molasses for anemia and its working wonders, taking 1 table spoon a day.

[Times Roman]

Pyrroloquinoline quinoneFrom Wikipedia, the free encyclopediaJump to: navigation, search
"PQQ" redirects here. For the IATA Airport Code PQQ, see Port Macquarie Airport.
Pyrroloquinoline quinone

Identifiers
CAS number 72909-34-3 Y
PubChem 1024
ChemSpider 997 Y
KEGG C00113 Y
MeSH PQQ+Cofactor
ChEBI CHEBI:18315 Y
Jmol-3D images Image 1
SMILES
[show]c1c2c([nH]c1C(=O)O)-c3c(cc(nc3C(=O)C2=O)C(=O)O)C(=O)O
InChI
[show]InChI=1S/C14H6N2O8/c17-10-4-2-6(14(23)24)15-8(4)7-3(12(19)20)1-5(13(21)22)16-9(7)11(10)18/h1-2,15H,(H,19,20)(H,21,22)(H,23,24) Y
Key: MMXZSJMASHPLLR-UHFFFAOYSA-N Y
--------------------------------------------------------------------------------
InChI=1/C14H6N2O8/c17-10-4-2-6(14(23)24)15-8(4)7-3(12(19)20)1-5(13(21)22)16-9(7)11(10)18/h1-2,15H,(H,19,20)(H,21,22)(H,23,24)
Key: MMXZSJMASHPLLR-UHFFFAOYAP
Properties
Molecular formula C14H6N2O8
Molar mass 330.206 g/mol
Density 1.963g/cm3
Boiling point 1018.6°C @ 760mmHg

Hazards
Flash point 569.8°C
Y (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Pyrroloquinoline quinone (PQQ) was discovered by J.G. Hauge as the third redox cofactor after nicotinamide and flavin in bacteria (although they hypothesised that it was naphthoquinone).[1] Anthony and Zatman also found the unknown redox cofactor in alcohol dehydrogenase and named it methoxatin.[2] In 1979, Salisbury and colleagues[3] as well as Duine and colleagues[4] extracted this prosthetic group from methanol dehydrogenase of methylotrophs and identified its molecular structure. Adachi and colleagues identified that PQQ was also found in Acetobacter.[5]

These enzymes containing PQQ are called quinoproteins. Glucose dehydrogenase, one of the quinoproteins, is used as a glucose sensor. Subsequently, PQQ was found to stimulate growth in bacteria.[6] In addition, antioxidant and neuro-protective effects were also found.[7]

In 1989, Rucker and colleagues reported that mice deprived of PQQ showed various abnormalities, and it was suggested that PQQ may also have an important nutritional role in other mammals.[8] In 2003, it was reported that aminoadipate semialdehyde dehydrogenase (AASDH) might also use PQQ as a cofactor, suggesting a possibility that PQQ is a vitamin in mammals.[9] Rucker and colleagues concluded that insufficient information is available so far to state that PQQ is a vitamin for mammals, although PQQ may be an important biological factor.[10]

It was recently shown that PQQ may stimulate growth of plants (cucumbers and tomatoes) in hydroponic culture and may be the causative factor in plant growth stimulation by a strain of Pseudomonas fluorescens bacterium.[11]

PQQ as a prosthetic group on Glucose Dehydrogenase has been utilized at the anode in an enzyme based fuel cell. [12]

Supplementation BenefitsPQQ is taken as a dietary supplement to support mitochondrial health and cellular energy production, and to protect the body from oxidative stress. Most notably, PQQ stimulates the spontaneous growth of new mitochondria in aging cells, and activates genes that govern mitochondrial reproduction, protection, and repair.

[edit] Antioxidant Capacity and Role in Mitochondrial HealthMitochondria are the primary engines of almost all bioenergy production in the human body and are among the most vulnerable physiological structures to destruction from oxidative damage. Scientists now recognize mitochondrial dysfunction as a key biomarker of aging. [13] [14][15][16][17][18]Relative to cellular DNA, mitochondrial DNA possesses few defenses against free radical damage, and is dependent upon antioxidants for protection. [19][20]PQQ’s powerful free radical–scavenging capacity provides the mitochondria with superior antioxidant protection due to its high molecular stability and the role it plays in energy transfer directly within the mitochondria. Unlike other antioxidants, the exceptional molecular stability of PQQ allows it to carry out thousands of electron transfers without undergoing molecular breakdown [21]

PQQ is especially effective in neutralizing superoxide and hydroxyl radicals,[22][23] two prominent causes of mitochondrial dysfunction.

According to a University of California at Davis study, “PQQ is 30 to 5,000 times more efficient in sustaining redox cycling (mitochondrial energy production) . . . than other common [antioxidant compounds], e.g. Ascorbic Acid (Vitamin C).”[24]

[edit] Mitochondrial BiogenesisIn 2010, researchers at the University of California at Davis released a peer-reviewed publication showing that PQQ’s critical role in growth and development stems from its unique ability to activate cell signaling pathways directly involved in cellular energy metabolism, development, and function.

Most significantly, the study demonstrated that PQQ not only protects mitochondria from oxidative stress—it promotes the spontaneous generation of new mitochondria within aging cells, a process known as mitochondrial biogenesis.[25] The implications of this revelation for human health and longevity are significant because the only other known methods proven to stimulate mitochondiral biogenesis in aging humans are intense aerobic exercise,[26] strict caloric restriction,[27] and certain medications such as thiazolidinediones[28] and the diabetes drug metformin.[29]

[edit] Activation of Signaling MoleculesThe team of researchers at the University of California analyzed PQQ’s influence over cell signaling pathways involved in the generation of new mitochondria and found that there are three signaling molecules activated by PQQ that cause cells to undergo spontaneous mitochondrial biogenesis:[30]

PQQ activates expression of PCG-1α (peroxisome proliferator-activated receptor gamma coactivator 1-alpha), a “master regulator” that mobilizes cells’ response to various external triggers. It directly stimulates genes that enhance mitochondrial and cellular respiration, growth, and reproduction. Its capacity to upregulate cellular metabolism at the genetic level favorably affects blood pressure, cholesterol and triglyceride breakdown, and the onset of obesity.[31]
PQQ triggers the CREB signaling protein (cAMP-response element-binding protein), which plays a pivotal role in embryonic development and growth. It also beneficially interacts with histones, molecular compounds shown to protect and repair cellular DNA.[32] CREB also stimulates the growth of new mitochondria.
PQQ regulates a recently discovered cell signaling protein called DJ-1. As with PCG-1α and CREB, DJ-1 is intrinsically involved in cell function and survival, has been shown to prevent cell death by combating intensive antioxidant stress,[33][34]and is of particular importance to brain health and function. DJ-1 damage and mutation have been conclusively linked to the onset of Parkinson’s disease and other neurological disorders.
[edit] NeuroprotectionPQQ is a potent neuroprotective nutrient that has been shown to protect memory and cognition in both aging animals and humans.[35][36] It has been shown to reverse cognitive impairment caused by chronic oxidative stress in pre-clinical models and improve performance on memory tests.[37] PQQ supplementation stimulates the production and release of nerve growth factor in cells that support neurons in the brain,[38] a possible explanation for the marked improvement of memory function it produces in aging humans and rats.

PQQ has also been shown to safeguard against the self-oxidation of the DJ-1 gene, an early step in the onset of Parkinson’s disease.[39]

PQQ protects brain cells against oxidative damage following ischemia-reperfusion injury—the inflammation and oxidative damage that result from the sudden return of blood and nutrients to tissues deprived of them by stroke.[40] Reactive nitrogen species (RNS) arise spontaneously following stroke and spinal cord injuries and impose severe stresses on damaged neurons, producing a significant proportion of subsequent long-term neurological damage.[41] PQQ suppresses RNS in experimentally induced strokes,[42] and provides additional protection following spinal cord injury by blocking inducible nitric oxide synthase (iNOS), a major source of RNS. [43]

In animal models, administration of PQQ immediately prior to induction of stroke significantly reduces the size of the damaged brain area.[44] These observations have been extended in vivo by showing that PQQ protects against the likelihood of severe stroke in an experimental animal model for stroke and brain hypoxia. [45]

PQQ interacts beneficially with the brain’s neurotransmitter systems. It protects neurons by modifying the N-Methyl-D-aspartate (NMDA) receptor site[46][47] and mediating excitotoxicity—the damaging consequence of long-term overstimulation of neurons that is associated with many neurodegenerative diseases and seizures. [48][49][50][51]

PQQ also protects the brain against neurotoxicity induced by other powerful toxins, including mercury[52](a suspected factor in the development of Alzheimer’s disease[53]) and oxidopamine[54] (a potent neurotoxin used by scientists to induce Parkinsonism in laboratory animals by destroying dopaminergic and noradrenergic neurons[55]).

PQQ prevents development of alpha-synuclein, a protein associated with Parkinson’s disease.[56] PQQ also protects nerve cells from the oxidizing ravages of the amyloid-beta protein linked with Alzheimer’s disease,[57] and works preventatively to block new amyloid beta molecular structures from forming before they can cause any damage.[58]

[edit] CognitionPQQ has been shown to promote memory, attention, and cognition in animals[59] and humans.

In a double-blind, placebo-controlled clinical trial conducted in Japan in 2007, supplementation with 20 mg per day of PQQ resulted in improvements on tests of higher cognitive function in a group of 71 middle-aged and elderly people aged between 40-70, who outperformed the placebo group by more than twofold in their standardized memory tests. [60]

Interestingly, the results of the study also suggest a synergistic relationship between PQQ and the nutrient coenzyme Q10 (CoQ10), which further amplified performance on standardized memory tests when subjects also took 300 mg per day of CoQ10. No adverse effects were linked to the supplementation, and the results demonstrated that PQQ, especially when combined with CoQ10, can be used to improve mental status and quality of life in older patients, and help slow or prevent age-related cognitive decline in middle-age patients.

[edit] CardioprotectionDamage from a heart attack, like a stroke, is inflicted via ischemia-reperfusion injury. Supplemental PQQ reduces the size of damaged areas in animal models of acute heart attack (myocardial infarction). Significantly, this occurs whether the supplement is given before or after the ischemic event itself, suggesting that supplementation within the first hours of medical response may offer profound benefits to heart attack victims.[61]

Researches at the University of California at San Francisco investigated this potential, comparing PQQ with the beta blocker metoprolol—a standard post-MI clinical treatment. Independently, both treatments reduced the size of the damaged damaged areas’ and protected against heart muscle dysfunction. When given together, the left ventricle’s pumping pressure was enhanced. The combination of PQQ with metoprolol also increased mitochondrial energy-producing functions—but the effect was modest compared with PQQ alone. Only PQQ favorably reduced lipid peroxidation. These results led the researches to conclude that “PQQ is superior to metoprolol in protecting mitochondria from ischemia/reperfusion oxidative damage.” [62]]

Subsequent research has also demonstrated that PQQ helps heart muscle cells resist acute oxidative stress by preserving and enhancing mitochondrial function. [63]

[edit] Supplement DosageDespite its classification as an essential nutrient,[64] no recommended daily intake of PQQ has been established.

Animal studies have demonstrated PQQ's support of healthy mitochondrial function with human equivalent dose (H.E.D.) as low as 1.44 milligrams per day,[65] the majority of actual human studies have used higher doses of 10-20mg or more. Consequently, nearly all PQQ supplements sold in the United States range from 10–20 mg.[66][67][unreliable source?]

[edit] References1.^ Hauge JG (1964). "Glucose dehydrogenase of bacterium anitratum: an enzyme with a novel prosthetic group". J Biol Chem 239: 3630–9. PMID 14257587.
2.^ Anthony C, Zatman LJ (1967). "The microbial oxidation of methanol. The prosthetic group of the alcohol dehydrogenase of Pseudomonas sp. M27: a new oxidoreductase prosthetic group". Biochem J 104 (3): 960–9. PMC 1271238. PMID 6049934. http://www.pubmedcentral.nih.gov/art...&artid=1271238.
3.^ Salisbury SA, Forrest HS, Cruse WB, Kennard O (1979). "A novel coenzyme from bacterial primary alcohol dehydrogenases". Nature 280 (5725): 843–4. doi:10.1038/280843a0. PMID 471057.
4.^ Westerling J, Frank J, Duine JA (1979). "The prosthetic group of methanol dehydrogenase from Hyphomicrobium X: electron spin resonance evidence for a quinone structure". Biochem Biophys Res Commun 87 (3): 719–24. doi:10.1016/0006-291X(79)92018-7. PMID 222269.
5.^ Ameyama M, Matsushita K, Ohno Y, Shinagawa E, Adachi O (1981). "Existence of a novel prosthetic group, PQQ, in membrane-bound, electron transport chain-linked, primary dehydrogenases of oxidative bacteria". FEBS Lett 130 (2): 179–83. doi:10.1016/0014-5793(81)81114-3. PMID 6793395.
6.^ Ameyama M, Matsushita K, Shinagawa E, Hayashi M, Adachi O (1988). "Pyrroloquinoline quinone: excretion by methylotrophs and growth stimulation for microorganisms". Biofactors 1 (1): 51–3. PMID 2855583.
7.^ Rucker R, Chowanadisai W, Nakano M. (2009). "Potential physiological importance of pyrroloquinoline quinone.". Altern Med Rev. 14 (3): 179–83.
8.^ Killgore J, Smidt C, Duich L, Romero-Chapman N, Tinker D, Reiser K, Melko M, Hyde D, Rucker RB (1989). "Nutritional importance of pyrroloquinoline quinone". Science 245 (4920): 850–2. doi:10.1126/science.2549636. PMID 2549636.
9.^ Kasahara T, Kato T (2003). "Nutritional biochemistry: A new redox-cofactor vitamin for mammals". Nature 422 (6934): 832. doi:10.1038/422832a. PMID 12712191.
10.^ Rucker R, Storms D, Sheets A, Tchaparian E, Fascetti A (2005). "Biochemistry: is pyrroloquinoline quinone a vitamin?". Nature 433 (7025): E10–1; discussion E11–2. doi:10.1038/nature03323. PMID 15689994.
11.^ Choi, O., Kim, J., Kim, J.-G., Jeong, Y., Moon, J. S., Park, C. S., Hwang, I. (2008). "PLANTS INTERACTING WITH OTHER ORGANISMS Pyrroloquinoline Quinone Is a Plant Growth Promotion Factor Produced by Pseudomonas fluorescens B16". Plant Physiology 146 (2): 657–668. doi:10.1104/pp.107.112748. PMC 2245851. PMID 18055583. http://www.pubmedcentral.nih.gov/art...&artid=2245851.
12.^ Noriko Yuhashia, Masamitsu Tomiyamab, Junko Okudaa, Satoshi Igarashia, Kazunori Ikebukuroa and Koji Sodea, (2005). "Development of a novel glucose enzyme fuel cell system employing protein engineered PQQ glucose dehydrogenase". Biosensors and Bioelectronics 20 (10): 2145–2150. doi:10.1016/j.bios.2004.08.017. PMID 15741089.
13.^ Bliznakov, EG (Dec 1999). "Aging, mitochondria, and coenzyme Q(10): the neglected relationship". Biochimie. 81 (81(12)): 1131–2. PMID 10917692.
14.^ Linnane, AW; Marzuki, S; Ozawa, T; Tanaka, M (1989). "Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases". Lancet 1 (8639): 642–5. doi:10.1016/S0140-6736(89)92145-4. PMID 2564461. edit
15.^ Lanza, IR; Nair, KS (2010 Sep). "Mitochondrial metabolic function assessed in vivo and in vitro". Current Opinion in Clinical Nutrition and Metabolic Care 13 (5): 511–7. doi:10.1097/MCO.0b013e32833cc93d. PMID 20616711. edit
16.^ Mota, MP; Peixoto, FM; Soares, JF; Figueiredo, PA; Leitão, JC; Gaivão, I; Duarte, JA (2010 Sep). "Influence of aerobic fitness on age-related lymphocyte DNA damage in humans: relationship with mitochondria respiratory chain and hydrogen peroxide production". Age (Dordrecht, Netherlands) 32 (3): 337–46. doi:10.1007/s11357-010-9138-8. PMC 2926856. PMID 20640548. http://www.pubmedcentral.nih.gov/art...&artid=2926856. edit
17.^ Tranah, GJ (2011 Apr). "Mitochondrial-nuclear epistasis: Implications for human aging and longevity". Ageing Research Reviews 10 (2): 238–52. doi:10.1016/j.arr.2010.06.003. PMC 2995012. PMID 20601194. http://www.pubmedcentral.nih.gov/art...&artid=2995012. edit
18.^ Cho, DH; Nakamura, T; Lipton, SA (2010 Oct). "Mitochondrial dynamics in cell death and neurodegeneration". Cellular and Molecular Life Sciences 67 (20): 3435–47. doi:10.1007/s00018-010-0435-2. PMID 20577776. edit
19.^ Richter, C (1995). "Oxidative damage to mitochondrial DNA and its relationship to ageing". The international journal of biochemistry & cell biology 27 (7): 647–53. PMID 7648420. edit
20.^ Miquel, J (1992). "An update on the mitochondrial-DNA mutation hypothesis of cell aging". Mutation research 275 (3-6): 209–16. PMID 1383762. edit
21.^ Paz, MA; Martin, P; Flückiger, R; Mah, J; Gallop, PM (1996 Jul). "The catalysis of redox cycling by pyrroloquinoline quinone (PQQ), PQQ derivatives, and isomers and the specificity of inhibitors". Analytical Biochemistry 238 (2): 145–9. doi:10.1006/abio.1996.0267. PMID 8660603. edit
22.^ Hara, H; Hiramatsu, H; Adachi, T (2007 Mar). "Pyrroloquinoline quinone is a potent neuroprotective nutrient against 6-hydroxydopamine-induced neurotoxicity". Neurochemical Research 32 (3): 489–95. doi:10.1007/s11064-006-9257-x. PMID 17268846. edit
23.^ Urakami, T; Yoshida, C; Akaike, T; Maeda, H; Nishigori, H; Niki, E (1997). "Synthesis of monoesters of pyrroloquinoline quinone and imidazopyrroloquinoline, and radical scavenging activities using electron spin resonance in vitro and pharmacological activity in vivo". Journal of nutritional science and vitaminology 43 (1): 19–33. PMID 9151238. edit
24.^ Stites, TE; Mitchell, AE; Rucker, RB (2000). "Physiological importance of quinoenzymes and the O-quinone family of cofactors". The Journal of nutrition 130 (4): 719–27. PMID 10736320. edit
25.^ Chowanadisai, W; Bauerly, KA; Tchaparian, E; Wong, A; Cortopassi, GA; Rucker, RB (2010 Jan). "Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression". Journal of Biological Chemistry 285 (1): 142–52. doi:10.1074/jbc.M109.030130. PMC 2804159. PMID 19861415. http://www.pubmedcentral.nih.gov/art...&artid=2804159. edit
26.^ Lanza, IR; Sreekumaran Nair, K (2010 Aug). "Regulation of skeletal muscle mitochondrial function: genes to proteins". Acta Physiologica 199 (4): 529–47. doi:10.1111/j.1748-1716.2010.02124.x. PMID 20345409. edit
27.^ Spindler, SR (2010 Jul). "Caloric restriction: from soup to nuts". Ageing Research Reviews 9 (3): 324–53. doi:10.1016/j.arr.2009.10.003. PMID 19853062. edit
28.^ Fujisawa, K.; Nishikawa, T.; Kukidome, D.; Imoto, K.; Yamashiro, T.; Motoshima, H.; Matsumura, T.; Araki, E. (2009). "TZDs reduce mitochondrial ROS production and enhance mitochondrial biogenesis". Biochemical and Biophysical Research Communications 379 (1): 43–48. doi:10.1016/j.bbrc.2008.11.141. PMID 19084501. edit
29.^ Suwa, M; Egashira, T; Nakano, H; Sasaki, H; Kumagai, S (2006 Dec). "Metformin increases the PGC-1alpha protein and oxidative enzyme activities possibly via AMPK phosphorylation in skeletal muscle in vivo". Journal of Applied Physiology 101 (6): 1685–92. doi:10.1152/japplphysiol.00255.2006. PMID 16902066. edit
30.^ Chowanadisai, W; Bauerly, KA; Tchaparian, E; Wong, A; Cortopassi, GA; Rucker, RB (2010 Jan). "Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression". Journal of Biological Chemistry 285 (1): 142–52. doi:10.1074/jbc.M109.030130. PMC 2804159. PMID 19861415. http://www.pubmedcentral.nih.gov/art...&artid=2804159. edit
31.^ "Entrez Gene: PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha [ Homo sapiens GeneID: 10891."]. http://www.ncbi.nlm.nih.gov/gene/10891.
32.^ "Entrez Gene: CREBBP CREB binding protein [ Homo sapiens GeneID: 1387."]. http://www.ncbi.nlm.nih.gov/gene/1387.
33.^ Mitsumoto, A; Nakagawa, Y (2001). "DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin". Free radical research 35 (6): 885–93. PMID 11811539. edit
34.^ Taira, T; Saito, Y; Niki, T; Iguchi-Ariga, SMM; Takahashi, K; Ariga, H (2004 Feb). "DJ-1 has a role in antioxidative stress to prevent cell death". EMBO Reports 5 (2): 213–8. doi:10.1038/sj.embor.7400074. PMC 1298985. PMID 14749723. http://www.pubmedcentral.nih.gov/art...&artid=1298985. edit
35.^ Takatsu, H; Owada, K; Abe, K; Nakano, M; Urano, S (2009). "Effect of vitamin E on learning and memory deficit in aged rats". Journal of nutritional science and vitaminology 55 (5): 389–93. PMID 19926923. edit
36.^ "Effect of pyrroloquinoline quinone (PQQ) on mental status of middle-aged and elderly persons". Food Style 21 13 (7): 50–52. 2009.
37.^ Ohwada, K; Takeda, H; Yamazaki, M; Isogai, H; Nakano, M; Shimomura, M; Fukui, K; Urano, S (2008 Jan). "Pyrroloquinoline quinone (PQQ) prevents cognitive deficit caused by oxidative stress in rats". Journal of Clinical Biochemistry and Nutrition 42: 29–34. doi:10.3164/jcbn.2008005. PMC 2212345. PMID 18231627. http://www.pubmedcentral.nih.gov/art...&artid=2212345. edit
38.^ Murase, K; Hattori, A; Kohno, M; Hayashi, K (1993). "Stimulation of nerve growth factor synthesis/secretion in mouse astroglial cells by coenzymes". Biochemistry and molecular biology international 30 (4): 615–21. PMID 8401318. edit
39.^ Nunome, K; Miyazaki, S; Nakano, M; Iguchi-Ariga, S; Ariga, H (2008). "Pyrroloquinoline quinone prevents oxidative stress-induced neuronal death probably through changes in oxidative status of DJ-1". Biological & pharmaceutical bulletin 31 (7): 1321–6. PMID 18591768. edit
40.^ Jensen, FE; Gardner, GJ; Williams, AP; Gallop, PM; Aizenman, E; Rosenberg, PA (1994). "The putative essential nutrient pyrroloquinoline quinone is neuroprotective in a rodent model of hypoxic/ischemic brain injury". Neuroscience 62 (2): 399–406. doi:10.1016/0306-4522(94)***75-1. PMID 7830887. edit
41.^ Ono, K; Suzuki, H; Sawada, M (2010 Apr 5). "Delayed neural damage is induced by iNOS-expressing microglia in a brain injury model". Neuroscience Letters 473 (2): 146–150. doi:10.1016/j.neulet.2010.02.041. PMID 20178828. edit
42.^ Zhang, Y; Rosenberg, PA (2002). "The essential nutrient pyrroloquinoline quinone may act as a neuroprotectant by suppressing peroxynitrite formation". The European journal of neuroscience 16 (6): 1015–24. PMID 12383230. edit
43.^ Hirakawa, A; Shimizu, K; Fukumitsu, H; Furukawa, S (2009 Jan 9). "Pyrroloquinoline quinone attenuates iNOS gene expression in the injured spinal cord". Biochemical and Biophysical Research Communications 378 (2): 308–12. doi:10.1016/j.bbrc.2008.11.045. PMID 19026989. edit
44.^ Zhang, Y; Feustel, P; Kimelberg, H (2006 Jun 13). "Neuroprotection by pyrroloquinoline quinone (PQQ) in reversible middle cerebral artery occlusion in the adult rat". Brain Research 1094 (1): 200–6. doi:10.1016/j.brainres.2006.03.111. PMID 16709402. edit
45.^ Jensen, FE; Gardner, GJ; Williams, AP; Gallop, PM; Aizenman, E; Rosenberg, PA (1994). "The putative essential nutrient pyrroloquinoline quinone is neuroprotective in a rodent model of hypoxic/ischemic brain injury". Neuroscience 62 (2): 399–406. doi:10.1016/0306-4522(94)***75-1. PMID 7830887. edit
46.^ Aizenman, E; Hartnett, KA; Zhong, C; Gallop, PM; Rosenberg, PA (1992). "Interaction of the putative essential nutrient pyrroloquinoline quinone with the N-methyl-D-aspartate receptor redox modulatory site". Journal of Neuroscience 12 (6): 2362–9. PMID 1318959. edit
47.^ Aizenman, E; Jensen, FE; Gallop, PM; Rosenberg, PA; Tang, LH (1994). "Further evidence that pyrroloquinoline quinone interacts with the N-methyl-D-aspartate receptor redox site in rat cortical neurons in vitro". Neuroscience letters 168 (1-2): 189–92. doi:10.1016/0304-3940(94)90447-2. PMID 7518062. edit
48.^ Scanlon, JM; Aizenman, E; Reynolds, IJ (1997). "Effects of pyrroloquinoline quinone on glutamate-induced production of reactive oxygen species in neurons". European journal of pharmacology 326 (1): 67–74. doi:10.1016/S0014-2999(97)00137-4. PMID 9178657. edit
49.^ Hossain, MA (2005 Sep). "Molecular mediators of hypoxic-ischemic injury and implications for epilepsy in the developing brain". Epilepsy & Behavior 7 (2): 204–213. doi:10.1016/j.yebeh.2005.05.015. PMID 16054439. edit
50.^ Dong, XX; Wang, Y; Qin, ZH (2009 Apr). "Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases". Acta Pharmacologica Sinica 30 (4): 379–87. doi:10.1038/aps.2009.24. PMID 19343058. edit
51.^ Foran, E; Trotti, D (2009 Jul). "Glutamate transporters and the excitotoxic path to motor neuron degeneration in amyotrophic lateral sclerosis". Antioxidants & Redox Signaling 11 (7): 1587–602. doi:10.1089/ars.2009.2444. PMID 19413484. edit
52.^ Zhang, P; Xu, Y; Sun, J; Li, X; Wang, L; Jin, L (2009 Mar). "Protection of pyrroloquinoline quinone against methylmercury-induced neurotoxicity via reducing oxidative stress". Free Radical Research 43 (3): 224–33. doi:10.1080/10715760802677348. PMID 19191107. edit
53.^ Mutter J, C. A. (2010). "Does inorganic mercury play a role in Alzheimer's disease? A systematic review and an integrated molecular mechanism". Journal of Alzheimer's Disease 22 (2): 357–374. doi:10.3233/JAD-2010-100705. PMID 20847438. edit
54.^ Hara, H; Hiramatsu, H; Adachi, T (2007 Mar). "Pyrroloquinoline quinone is a potent neuroprotective nutrient against 6-hydroxydopamine-induced neurotoxicity". Neurochemical Research 32 (3): 489–95. doi:10.1007/s11064-006-9257-x. PMID 17268846. edit
55.^ Breese, GR; Knapp, DJ; Criswell, HE; Moy, SS; Papadeas, ST; Blake, BL (2005 Feb). "The neonate-6-hydroxydopamine-lesioned rat: a model for clinical neuroscience and neurobiological principles". Brain Research Reviews 48 (1): 57–73. doi:10.1016/j.brainresrev.2004.08.004. PMID 15708628. edit
56.^ Kobayashi, M; Kim, J; Kobayashi, N; Han, S; Nakamura, C; Ikebukuro, K; Sode, K (2006 Oct 27). "Pyrroloquinoline quinone (PQQ) prevents fibril formation of alpha-synuclein". Biochemical and Biophysical Research Communications 349 (3): 1139–44. doi:10.1016/j.bbrc.2006.08.144. PMID 16962995. edit
57.^ Zhang JJ; Zhang RF; Meng XK (2009 Oct 30). "Protective effect of pyrroloquinoline quinone against Abeta-induced neurotoxicity in human neuroblastoma SH-SY5Y cells". Neuroscience Letters 464 (3): 165–9. doi:10.1016/j.neulet.2009.08.037. PMID 19699263. edit
58.^ Kim, J; Kobayashi, M; Fukuda, M; Ogasawara, D; Kobayashi, N; Han, S; Nakamura, C; Inada, M et al. (2010). "Pyrroloquinoline quinone inhibits the fibrillation of amyloid proteins". Prion 4 (1): 26–31. PMC 2850417. PMID 20083898. http://www.pubmedcentral.nih.gov/art...&artid=2850417. edit
59.^ Takatsu, H; Owada, K; Abe, K; Nakano, M; Urano, S (2009). "Effect of vitamin E on learning and memory deficit in aged rats". Journal of nutritional science and vitaminology 55 (5): 389–93. PMID 19926923. edit
60.^ "Effect of pyrroloquinoline quinone (PQQ) on mental status of middle-aged and elderly persons". Food Style 21 13 (7): 50–52. 2009.
61.^ Zhu BQ, Zhou HZ, Teerlink JR, Karliner JS (2004 Nov). "Pyrroloquinoline quinone (PQQ) decreases myocardial infarct size and improves cardiac function in rat models of ischemia and ischemia/reperfusion". Cardiovascular Drugs and Therapy 18 (6): 421-31. doi:10.1007/s10557-004-6219-x. PMID 15770429. edit
62.^ Zhu BQ; Simonis U; Cecchini G; Zhou HZ; Li L; Teerlink JR; Karliner JS (2006 Jun). "Comparison of pyrroloquinoline quinone and/or metoprolol on myocardial infarct size and mitochondrial damage in a rat model of ischemia/reperfusion injury". Journal of Cardiovascular Pharmacology and Therapeutics 11 (2): 119–28. doi:10.1177/1074248406288757. PMID 16891289. edit
63.^ Tao, R; Karliner, J; Simonis, U; Zheng, J; Zhang, J; Honbo, N; Alano, C (2007). "Pyrroloquinoline quinone preserves mitochondrial function and prevents oxidative injury in adult rat cardiac myocytes". Biochemical and Biophysical Research Communications 363 (2): 257–62. doi:10.1016/j.bbrc.2007.08.041. PMC 2844438. PMID 17880922. http://www.pubmedcentral.nih.gov/art...&artid=2844438. edit
64.^ Zhang, Y; Rosenberg, PA (2002). "The essential nutrient pyrroloquinoline quinone may act as a neuroprotectant by suppressing peroxynitrite formation". The European journal of neuroscience 16 (6): 1015–24. PMID 12383230. edit
65.^ Stites, T; Storms, D; Bauerly, K; Mah, J; Harris, C; Fascetti, A; Rogers, Q; Tchaparian, E et al. (2006). "Pyrroloquinoline quinone modulates mitochondrial quantity and function in mice". The Journal of nutrition 136 (2): 390–6. PMID 16424117. edit
66.^ "PQQ Dosage; What size pyrroloquinoline quinone pills should I take?". PQQ. http://pyrroloquinoline-quinone.com/...-quinone-pills.
67.^ "Examine.com: Pyrroloquinoline quinone". http://examine.com/supplements/Pyrro...oline+quinone/.

[Times Roman]

Agree i was skeptic too after using it for 6 months and not being sick that kind of changed my mind.

http://dochand.wordpress.com/categor...oxide-therapy/

The medical community and pharmaceutical have no money to make with H202 its so cheap cost pennies a day, and is not a drug. They will say its dangerous to the body, will cause stomach to melt and dumb stuff like that. Its the same as dropping H202 on your finger, it will turn white and bubble, this is oxygen being released. It as the same effect in the body but must be diluted with distilled water.

I love earth clinic, there are lots of home remedies on there that science will say are worthless but its because there is no money to be made. My medical doctor put me on black strap molasses for anemia and its working wonders, taking 1 table spoon a day.

I read the article, and they are talking about microbes in the colon and vagina. Are you saying you put H2O2 in a bag and give yourself an enema with the stuff?

One of the problems with this line of reasoning, is that "germs" are bad. This is not true. There are good and bad germs. in fact, most are simply benign, or neutral. It becomes bad when you try to eliminate the natural intestinal fauna found in the digestive tract.

The first thing I saw on your link was when this doc said, "don't try this at home until you've been counsilled one on one by me". So he is fishing for a fee?

[Times Roman]

even Wiki has this to say about Hydrogen Peroxide therapy....

Alternative usesSee also: Liquid Oxygen (supplement)
Following the call by alternative medicine advisors for drinking diluted hydrogen peroxide, and using it in various ways such as in shampoo and as an additive to toothpaste, as a treatment to illness in general and cancer in particular, the American Cancer Society states that "there is no scientific evidence that hydrogen peroxide is a safe, effective or useful cancer treatment", and advises cancer patients to "remain in the care of qualified doctors who use proven methods of treatment and approved clinical trials of promising new treatments." [40]
Another controversial alternative medical procedure is inhalation of hydrogen peroxide at a concentration of about 1%. Intravenous usage of hydrogen peroxide has been linked to several deaths.[41][42]

So again, I'm asking for some data. Mate, there is no conspiracy by the pharmaceutical companies. There is either data, or there is not....

[yannick35]

Yuke no i mix the peroxide with distilled water. Also i am not saying someone with cancer does not follow the advise is a professional, but adding H202 can certainly help. I have been using it for a while now and feel great, its not a fix all. I have read some stuff off the internet, but most was from earth clinic where i posted the link. And if there is no conspiracy by the pharmaceutical company explain to me why last year they found a cure for cancer and the pharaceutical company where not interested in it.

Pharmaceutical compagny and medical community are a big money machine, doctor as ordered to prescrib pills, my mother was put on cholesterol pills she feels awful, i sent her to my medical doctor that put me on TRT he told her that 1 person on 3 suffers terrible side effect from cholesterol drugs. Sorry but pharmaceutical will provide data that suites them for sales.

[SexySweetheart]

daaaaamn timesroman.....having a boring weekend? lol
that ws a hell of a post... i think a few of my brain cells died while I tried to wrap my head around what I was reading lol

[yannick35]

times roman apologize first because i did not want to hijack your treat which as always is very informative. My views on the scientific studies are very weak. As you know i am a believer of prolotherapy, if you search the internet you will find studies medical and scientific that says prolotherapy is worthless and does nothing.

I have spoken to many people who stated the same, the problem with theses studies is that before someone gets treated with prolotherapy they need to get a compete blood test, the main reason why i was not treated for 6 months due to anemia, my blood was not pure enough to repair my body.

Most studies take half and half don't even get blood test first, and most of the time the injections and quantity are wrong. Prolotherapy is 5cc of dextrose with 35cc of xylocaine the needle must be at least 3 inches long to reach the lower back ligaments and 6 inches long for the hip joint.

I had serious lower back pain, ligament laxity and a pelvic that would get unaligned all the time, worst is i went to the stupid chiro that got me even worst. With prolotherapy and PRP my pelvic is now stable and my back pain are almost all gone. You see its hard for me to say its worthless because after 10 years of going to one so called specialist to another prolo fixed the problem at the cause. If it was worthless as they say, my pelvic would still be getting unaligned each day and i could barely walk.

[Times Roman]

Just would like to see the data, that's all.

For example, pharma companies won't touch MSM, since so cheap. But the vets were giving it to old race horses out to pasture for years before anyone caught on humans could take it as well. I've been taking it for almost 14 years now, and my knees and related pain are mangeagable. Even Wiki has this to say about MSM...

http://en.wikipedia.org/wiki/Methylsulfonylmethane
Effects on healthStanley W. Jacob reported having administered MSM to over 18,000 patients with a variety of ailments;[3] he co-authored a book promoting MSM with a variety of claims, including its supposed utility as a natural source of "biologically active sulfur,"[4] suggesting that people are deficient in such forms of sulfur in their dietary intake. There is no Dietary Reference Intake (DRI) or Daily Value established for sulphur; it is readily available in onions, garlic and cruciferous vegetables and in protein-containing foods, including nuts, seeds, milk and eggs.[5]

The claims for the need for sulfur supplementation originate with Robert Herschler, a biochemist who patented "Dietary and pharmaceutical uses of methylsulfonylmethane and compositions comprising it" in 1982; he claimed that MSM was useful in stress, mucous-membrane inflammation, allergies and gastrointestinal conditions.[6] Registered dietitian Kerry Lang on quackwatch disparages this claim, pointing out:[5]

OsteoarthritisA review by S. Brien, P. Prescott, N. Bashir, H. Lewith and G. Lewith of the two small randomized controlled trials of methylsulfonylmethane in osteoarthritis knee pain relief[11][12] "reported significant improvement in pain outcomes in the treatment group compared to comparator treatments; however, methodological issues and concerns over optimal dosage and treatment period were highlighted."[13]

The two trials included only 168 people, of whom 52 actually received the drug, so the review authors are careful to state: "No definitive conclusion can currently be drawn" and there is no "definitive evidence that MSM is superior to placebo in the treatment of mild to moderate osteoarthritis of the knee."[13] While one of the two studies suggests that taking MSM for 12 weeks or less may be safe, "further research is needed to assess its safety for long-term use."[14] Side effects of MSM ingestion include stomach upset, diarrhoea and headache.[14] In the absence of studies into dosage, longer-term safety and definitive efficacy trials, MSM must be considered experimental and should not be self-administered or prescribed outside clinical trials.[14]

After several reports that MSM helped arthritis in animal models, one study by P.R. Usha et al. had suggested that 1.5 g per day MSM (alone or in combination with glucosamine sulfate) was helpful in relieving symptoms of knee osteoarthritis.[12] The Usha clinical trial, however, was outsourced to India and conducted by researchers with little prior experience in clinical trials; tests were described without associated data, while some results were unsupported by the data that was shown. K.S. Jayaraman has warned that such outsourcing of clinical trials can be "rash" and "risky," citing deficient ethics committees as well as an unethical approach to patient recruitment.[15]

Kim et al. conducted a second clinical trial of MSM for treatment of patients with osteoarthritis of the knee. Twenty-five patients took 6 g/day MSM and 25 patients took a placebo for 12 weeks. Ten patients did not complete the study, and intention to treat analysis was performed. Patients who took MSM reported reduced pain and improved physical function, but no evidence was found of a more general anti-inflammatory effect; there were no significant changes in two measures of systemic inflammation: C-reactive protein level and erythrocyte sedimentation rate.[11] Not counting an unpublished, no-control group trial by Lawrence, these two articles are the only clinical-trial support for MSM for osteoarthritis.


So some clinical studies were done on MSM, without the backing of pharma companies. but when i look for H2O2 therapy, I find very little outside the link and website you provided earlier. Here's the problem. YOU may find relief, but how do I know it's not the placebo effect?

[Times Roman]

^ so I challange you... show me the data!

[dec11]

damn, saw the thread title and thought Slayer had released a new album without me knowing about it

[Times Roman]

naw, I'm going to get more involved in the things I've been learning about for the last asdoif years........

There is a lot of good information out there

[Times Roman]

Yuke no i mix the peroxide with distilled water. Also i am not saying someone with cancer does not follow the advise is a professional, but adding H202 can certainly help. I have been using it for a while now and feel great, its not a fix all. I have read some stuff off the internet, but most was from earth clinic where i posted the link. And if there is no conspiracy by the pharmaceutical company explain to me why last year they found a cure for cancer and the pharaceutical company where not interested in it.

Pharmaceutical compagny and medical community are a big money machine, doctor as ordered to prescrib pills, my mother was put on cholesterol pills she feels awful, i sent her to my medical doctor that put me on TRT he told her that 1 person on 3 suffers terrible side effect from cholesterol drugs. Sorry but pharmaceutical will provide data that suites them for sales.

the pharmaceutical companies are not some benevolent organization that seeks the betterment of mankind! instead they are a "for profit" company. pure and simple. if they do not see a profit in it, then of course they will not be interested.

I would be interested in seeing what you mean by "they found a cure for cancer and the pharaceutical company where not interested in it". Please provide a link =)

[yannick35]

Canadian researchers find a simple cure for cancer, but major pharmaceutical companies are not interested.

Researchers at the University of Alberta, in Edmonton, Canada have cured cancer last week, yet there is a little ripple in the news or in TV. It is a simple technique using very basic drug. The method employs dichloroacetate, which is currently used to treat metabolic disorders. So, there is no concern of side effects or about their long term effects.


This drug doesn’t require a patent, so anyone can employ it widely and cheaply compared to the costly cancer drugs produced by major pharmaceutical companies.


Canadian scientists tested this dichloroacetate (DCA) on human’s cells; it killed lung, breast and brain cancer cells and left the healthy cells alone. It was tested on Rats inflicted with severe tumors; their cells shrank when they were fed with water supplemented with DCA. The drug is widely available and the technique is easy to use, why the major drug companies are not involved? Or the Media interested in this find?


In human bodies there is a natural cancer fighting human cell, the mitochondria, but they need to be triggered to be effective. Scientists used to think that these mitochondria cells were damaged and thus ineffective against cancer. So they used to focus on glycolysis, which is less effective in curing cancer and more wasteful. The drug manufacturers focused on this glycolysis method to fight cancer. This DCA on the other hand doesn’t rely on glycolysis instead on mitochondria; it triggers the mitochondria which in turn fights the cancer cells.


The side effect of this is it also reactivates a process called apoptosis. You see, mitochondria contain an all-too-important self-destruct button that can't be pressed in cancer cells. Without it, tumors grow larger as cells refuse to be extinguished. Fully functioning mitochondria, thanks to DCA, can once again die.


With glycolysis turned off, the body produces less lactic acid, so the bad tissue around cancer cells doesn't break down and seed new tumors.


Pharmaceutical companies are not investing in this research because DCA method cannot be patented, without a patent they can’t make money, like they are doing now with their AIDS Patent. Since the pharmaceutical companies won’t develop this, the article says other independent laboratories should start producing this drug and do more research to confirm all the above findings and produce drugs. All the groundwork can be done in collaboration with the Universities, who will be glad to assist in such research and can develop an effective drug for curing cancer.

This article wants to raise awareness for this study, hope some independent companies and small startup will pick up this idea and produce these drugs, because the big companies won’t touch it for a long time.

This was all over the news last year

[lovbyts]

In case you didnt mention the H202 has to be Food grade, not the OTC stuff you buy at the drug store and as he noted it needs to be mixed with distilled water because the fluoride in tap water keeps it from working not to mention poisons us slowly.

[yannick35]

My current medical doctor as many contradictions about many things, he is against vegetarian diets, he treated many Olympic athletes and all of them where meat eaters, he is also one to prone the benefits of saturated fats and how to heal the body instead of destroying it. No hamburgers or crappy bacon but a red meat coconut oil.

He did not hesitate to put me on testosterone therapy and does it with many of is patience, he is not against using steroids to boost one immune system either or put someone on for a short period of time.

MSM been taking it for years myself, along with collagen and glucosamine complex. Of course once more you read studies and they will tell you its worthless.

For H202 one of my friends who work in a life extension clinic told me about this last year, i have been using it on and off, mixing with ACV and distilled water, and some colloidal silver. I have a lot more energy when am on H202 find my allergies to be better in the summer and lot more. I do not have any studies to back this up a part from the feedback of real people on earth clinic and other forums that i found on the internet. For sure the FDA is against this because its so cheap it cost pennies a day.

But like i said to each is own i guess.

[yannick35]

In case you didnt mention the H202 has to be Food grade, not the OTC stuff you buy at the drug store and as he noted it needs to be mixed with distilled water because the fluoride in tap water keeps it from working not to mention poisons us slowly.

Lovbyts yes it is mentionner earlier 35% food grade, glade you know about it, the OTC stuff is too unstable to drink. H202 needs to be diluted in distilled water before using. I have also been drinking distilled water for about 6 months now.

[VMAAG]

What gives? Why are you posting a link to LEF and when I posted a link some big, bad monitor came and took it off? Let's apply the rules to everyone. There should be no favoritism. Furthermore I use to work for LEF and was even there last year when they first introduced PPQ and know first hand how valuable their articles are. So let's get on the same page as far as links go please. Thank you.

[Times Roman]

What gives? Why are you posting a link to LEF and when I posted a link some big, bad monitor came and took it off? Let's apply the rules to everyone. There should be no favoritism. Furthermore I use to work for LEF and was even there last year when they first introduced PPQ and know first hand how valuable their articles are. So let's get on the same page as far as links go please. Thank you.

there are a few levels to staff positions, monitor being a lower level and not having the authority to edit your links. It would have had to been a vet or admin. There are a few rules to posting links. The spirit of posting a link would be to not post a link to a competitor, to a source for aas, or to porn. But my link does not violate the spirit of either of these. In fact, i prefer it when someone supplies the link to the article, as quite often, there are other related articles you can find on the same website.

Posting a link is a way of validating data or an article. I have always done this, here on this board, since i've been coming here. I don't have access to any of the details as to why your link was removed. If it didn't violate any rules, then it sounds like you should have been good to go, and I apologize for the removal.

I find it intersting you worked for LEF. I've been reading their articles for years. And I agree with you, they have some amazing articles. If you have any other interesting articles on this subject, I encourage you to share it with us, and include the link! =)

(having said all of that, if there is a Rule that says "NO posting of links of any sort", could you show me? I don't profess to know all the rules, and quite often just let common sense determine my behaviour)

[Times Roman]

My current medical doctor as many contradictions about many things, he is against vegetarian diets, he treated many Olympic athletes and all of them where meat eaters, he is also one to prone the benefits of saturated fats and how to heal the body instead of destroying it. No hamburgers or crappy bacon but a red meat coconut oil.

He did not hesitate to put me on testosterone therapy and does it with many of is patience, he is not against using steroids to boost one immune system either or put someone on for a short period of time.

MSM been taking it for years myself, along with collagen and glucosamine complex. Of course once more you read studies and they will tell you its worthless.

For H202 one of my friends who work in a life extension clinic told me about this last year, i have been using it on and off, mixing with ACV and distilled water, and some colloidal silver. I have a lot more energy when am on H202 find my allergies to be better in the summer and lot more. I do not have any studies to back this up a part from the feedback of real people on earth clinic and other forums that i found on the internet. For sure the FDA is against this because its so cheap it cost pennies a day.

But like i said to each is own i guess.

people stopped using colloidal silver about 60 years ago due to advances in modern medicine, and specifically anti biotics.

drinking distilled water is OK. there are pros and cons to it, but it doesn't have any medicinal value beyond that of ordinary water

not sure what ACV is? Apple Cidar Vinegar?

there was an ad in the back of Pop Sci that promoted the use and making of "special" water. Somehow, the position of the hydrogen atom relative to the oxygen atom is the key, and they claimed that not only does their machine (avaliable for purchase) make this adjustment for you, it brings on a whole host of other medical benefits.

Are you familar with what i am talking about?

my wifes grandfather had this wonderful cure for warts. he would take a twig off a willow tree, burn the end of it and then blow it out. quickly, he'd rub the hot end on your wart, and recite some passage out of the bible. then he'd cut the end off the stick, throw the end in a little hole in the ground, and then bury it. put a bandaid on the wart for a week, don't take it off, and in a week, the wart would be gone. Granny would swear that it works every time. and everyone around her would nod their approval, that it worked.

what i am trying to say, mate, is that without data, at best all we have is the placebo effect.

There is a reason I keep asking you for data. Without data, it's just bullshit.

I know it works for you. And people swear that Grandpa's wart removal technique works also.

But the days of snake oil are gone. It is one thing to claim something as valid. But please be prepared to back it up with data.

This is called critical thinking. You should be asking the same things when you go to these alternative clinics. If they cannot offer any hard data, but only anecdotal information, it's time to grab your wallet and haul ass! Seriously!!

[Times Roman]

Canadian researchers find a simple cure for cancer, but major pharmaceutical companies are not interested.

Researchers at the University of Alberta, in Edmonton, Canada have cured cancer last week, yet there is a little ripple in the news or in TV. It is a simple technique using very basic drug. The method employs dichloroacetate, which is currently used to treat metabolic disorders. So, there is no concern of side effects or about their long term effects.


This drug doesn’t require a patent, so anyone can employ it widely and cheaply compared to the costly cancer drugs produced by major pharmaceutical companies.


Canadian scientists tested this dichloroacetate (DCA) on human’s cells; it killed lung, breast and brain cancer cells and left the healthy cells alone. It was tested on Rats inflicted with severe tumors; their cells shrank when they were fed with water supplemented with DCA. The drug is widely available and the technique is easy to use, why the major drug companies are not involved? Or the Media interested in this find?


In human bodies there is a natural cancer fighting human cell, the mitochondria, but they need to be triggered to be effective. Scientists used to think that these mitochondria cells were damaged and thus ineffective against cancer. So they used to focus on glycolysis, which is less effective in curing cancer and more wasteful. The drug manufacturers focused on this glycolysis method to fight cancer. This DCA on the other hand doesn’t rely on glycolysis instead on mitochondria; it triggers the mitochondria which in turn fights the cancer cells.


The side effect of this is it also reactivates a process called apoptosis. You see, mitochondria contain an all-too-important self-destruct button that can't be pressed in cancer cells. Without it, tumors grow larger as cells refuse to be extinguished. Fully functioning mitochondria, thanks to DCA, can once again die.


With glycolysis turned off, the body produces less lactic acid, so the bad tissue around cancer cells doesn't break down and seed new tumors.


Pharmaceutical companies are not investing in this research because DCA method cannot be patented, without a patent they can’t make money, like they are doing now with their AIDS Patent. Since the pharmaceutical companies won’t develop this, the article says other independent laboratories should start producing this drug and do more research to confirm all the above findings and produce drugs. All the groundwork can be done in collaboration with the Universities, who will be glad to assist in such research and can develop an effective drug for curing cancer.

This article wants to raise awareness for this study, hope some independent companies and small startup will pick up this idea and produce these drugs, because the big companies won’t touch it for a long time.

This was all over the news last year

is this your data?

link please!

[yannick35]

Yes i know what you mean but for now i am the ginnea pig, i am not telling anyone to get on H202, i noticed that when i mix about 8-10 drops of it in distilled water with apple cider vinegar its does wonders for my allergies, seasonal like hey fever.

H202 was using in 1920 to cure malaria and other disease, there are some studies that will say pathogens die in oxygen environnement, but like i said most medical website will warn not to use H202 because it will disolve internal organs, and idiot stuff like that, same as for TRT most of theses websites will say its not good and packed with side effects.

[yannick35]

times romain there are zillions of links off the internet for that topic, i am not sure why you never heard of this before, its was a serious scandal last year, just do a search for cancer cure pharmaceutical.

[VMAAG]

there are a few levels to staff positions, monitor being a lower level and not having the authority to edit your links. It would have had to been a vet or admin. There are a few rules to posting links. The spirit of posting a link would be to not post a link to a competitor, to a source for aas, or to porn. But my link does not violate the spirit of either of these. In fact, i prefer it when someone supplies the link to the article, as quite often, there are other related articles you can find on the same website.

Posting a link is a way of validating data or an article. I have always done this, here on this board, since i've been coming here. I don't have access to any of the details as to why your link was removed. If it didn't violate any rules, then it sounds like you should have been good to go, and I apologize for the removal.

I find it intersting you worked for LEF. I've been reading their articles for years. And I agree with you, they have some amazing articles. If you have any other interesting articles on this subject, I encourage you to share it with us, and include the link! =)

(having said all of that, if there is a Rule that says "NO posting of links of any sort", could you show me? I don't profess to know all the rules, and quite often just let common sense determine my behaviour)

It was a link to an LEF article. That's what was so frustrating. It was some very valuable info and it was removed from here. I use the LEF articles all the time for my clients and know their articles inside and out since we were required to read them and then were tested on them. Anyway I'll try it again in the near future and see if perhaps it stays.

[DrHealth]

IV Ozone therapy & Hyperbaric Oxygen Chamber therapies work wonders. I've been on these therapies for months and I must say my mental clarity is much higher and I've not been sick since.

[yannick35]

IV Ozone therapy & Hyperbaric Oxygen Chamber therapies work wonders. I've been on these therapies for months and I must say my mental clarity is much higher and I've not been sick since.

Thanks for feedback Dr health, many people will dismiss H202 therapy due to lack of data and placebo effect, i was not sick at all, when using H202, i usually get sick in the winter, also this year my season allergies where much better. Earth clinic as some amazing feedback on H202 too.

[DrHealth]

What is Ozone Therapy?

Dr. Ferchoff is the leading expert in the medical use of ozone in the United States. Ozone therapy is a unique form of therapy that both heals and detoxifies at the same time. It used to treat a variety of chronic disease including cardiovascular disease, diabetes, Lyme disease, chronic hepatitis, herpes, chronic fatigue states, chemical sensitivity, macular degeneration, chronic bladder conditions, colitis, auto-immune diseases, and Crohn’s disease.

What Is Ozone?

The oxygen you breathe is present in the air as a pair of oxygen atoms. This is the most stable form of oxygen, and it’s colorless. Ozone is a blue colored form of oxygen (it=s what makes the sky blue), and unlike regular oxygen, it is composed of three oxygen atoms instead of two. It is the addition of the third oxygen atom that makes ozone “supercharged” oxygen, and gives it all of its remarkable medical properties.

The use of ozone to treat various medical conditions was first developed in Germany in the early 1950's. Today, medical ozone therapy is common throughout Europe, and its use has gradually been spreading in America over the last 25 years.

Ozone Is Toxic Isn't It?

Anything, including water and oxygen, is toxic if given in amounts that exceed the body's capacity to utilize it. Ozone is found naturally in the body. The white cells make it as part of the immune response. Pure medical grade ozone, when it is used according to the established medical guidelines, has a safety record that is unparalleled.

Medical Properties Of Ozone

Ozone has five properties that account for why it works so well not only for macular degeneration, but also for most other chronic age related conditions as well:

Ozone is a potent regulator of the immune system. This means that when the immune system is overactive (as in auto-immune disease), ozone will calm it down. Conversely, when the immune system is under active as in cancer, AIDS, and chronic infections, ozone will stimulate it. This unique ability of ozone stems from its action on the membranes of white cells that causes them to produce immune related messenger molecules called cytokines. Examples of cytokines are gamma interferon, interleukin-2, colony stimulating factor, and TNF-alpha just to name a few.

Ozone stimulates increased uptake of oxygen by stimulating the enzyme diphosphoglycerate (DPG). DPG enables the release of oxygen from the hemoglobin molecule so that it can be taken up into the cell. In the absence of an adequate amount of DPG, our cells become starved for oxygen. This is a common problem in diabetics.

Ozone improves circulation. It does this by enhancing the flow characteristics of blood as a liquid. This effect enables more of the oxygen carrying hemoglobin to reach the capillaries where ultimately the cells will receive more of the oxygen they require. Many patients with chronic inflammatory conditions have impaired circulation.

Ozone increases antioxidant protection more than any other therapy including vitamin C.Most people with chronic disease have deficient antioxidant defenses.

Ozone is a powerful mitochondrial stimulant. The fundamental underlying cause behind all degenerative disease from diabetes to heart disease to cancer is decreased mitochondrial energy production. Ozone can often correct this problem.

[l2elapse]

can you give me a cliff notes version Times..im feeeling lazy

[Times Roman]

times romain there are zillions of links off the internet for that topic, i am not sure why you never heard of this before, its was a serious scandal last year, just do a search for cancer cure pharmaceutical.

Yannick,

Not trying to pick on you. Here is your original comment:

I am on oxygen therapy using 8-10 drops of H202 hydrogen peroxide 35% food grade, this stuff kills nearly all pathogens in the body.

this is a huge statement. I am asking you what is the basis for such a huge claim?

later on, you say you are the guinnee pig and there is really not much data. So does this mean there is NO data? So if NO data, why would you come off and say...."this stuff kills nearly all pathogens in the body"? How would you know this to be true? Or, more likely, you do NOT know it to be true, and in fact, you are merely guessing?


My mother in law does this crap all the time too. She reads stuff in EarthClinic, and then tells me I should try it. The problem with EarthClinic and sites similar to it, is they will make huge statements... "Apple Cider Vinegar will eliminate your high blood pressure in two weeks!" without a shred of data.... instead, they opt to use anecdotal evidence. Which is NOT evidence at all! It is called heresay. And then if you try to argue with someone that chooses to follow the recommendations of the site, you always get the knee jerk reaction..."the reason you do not hear about this is because it is freely available, the pharma companies can't make money off it, so no clinical studies". Wrong again.... look at MSM, a well documented, well researched substance that the pharmaceutical companies cannot patent, yet we still have clinical data showing that it works.

So please, before you make huge statements like "this stuff kills nearly all pathogens in the body", make sure you know what you are talking about. Fair enough?

[Times Roman]

IV Ozone therapy & Hyperbaric Oxygen Chamber therapies work wonders. I've been on these therapies for months and I must say my mental clarity is much higher and I've not been sick since.

you know, i have heard of hyperbaric oxygen chamber therapies. Although expensive (not everyone has these devises laying around the livingroom), it promotes improved healing, and if not mistaken, improves recovery time for burn victims. I believe few hospitals have such devices. Around 5+ years ago, it was in the news that Michael Jackson may have had one of these devices, and may have slept in it as well.

To really get maximum benefit out of it, ideally, it would be weight room size, and you would up the pressure, then workout for awhile, with super satured O2 levels in the blood.

But I've never had the privilege of using...