Thread: Question about E2 levels.
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03-29-2012, 03:10 PM #1Associate Member
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Question about E2 levels.
I've read the stickies, and other information on E2 levels, and have come to the conclusion that it's basically common knowledge that injecting testosterone on a more frequent basis, i.e. smaller doses every 3.5 days leads to a more steady level of testosterone, as well as less of a spike in E2 levels, and thus less of a chance that an A.I. would be required.
While I understand this, how does this pertain to someone who already has extremely high/elevated E2 levels (over and above the highest limit of the E2 test range)?
I had an E2 Estradiol test about 1 month ago (not the sensitive assay for males test though), and my result was 178 pmol/L from a range of < 156.
I'm planning on beginning sub-Q test-cypionate injections on Monday, doing 50-60 mg every 3.5 days, but want to lower my E2 levels A.S.A.P.
Would I be best to use an A.I. for a few weeks just to get my E2 levels down quickly, than lay off the A.I. and just let the shorter injection protocol continue to lower my E2 levels, or just forget about an A.I. all together, and just let the shorter injection protocol do it's stuff on it's own?
I just want to be able to use as much of the test-cyp that I can, as quickly as I can.
Thanks
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03-29-2012, 08:50 PM #2
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03-29-2012, 09:24 PM #3Associate Member
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I've only been on TRT for a little over 1 month.
What I mean by that comment is, that I realize the more aromatase enzyme one has in their body, the more likelihood there is that a higher percentage of the testosterone -cypionate they are injecting could/might be converted into estrogen. So I'm thinking the sooner I can inhibit the aromatase enzymes from converting less of the testosterone into estrogen, my body will be able to use more of the testosterone for how it's supposed to be used...as TESTOSTERONE! (i.e. less of it will get converted into estrogen)
At least that's what I assume would happen if my E2 levels are lowered, or if I'd have an aromatase inhibitor.
I might be off on some of the semantics, or the terminology, but I hope you understand what I'm trying to say.
I guess I just want to be able to have as much of the testosterone (of each injection that I take) be able to bind to my androgen receptors instead of having a large portion of it being converted to estrogen.
Sorry if I'm being naive, or not explaining myself clearly.
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03-30-2012, 07:03 AM #4Member
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I think people here will probably tell you that you need the sensitive assay for estradiol to know your levels for sure...but I agree that it would appear you are high anyway. Injecting more frequently will help prevent some of that test. turning to E2, but if you were at a high level before starting TRT, it won't likely be coming down with TRT. (other factors play a role in E2 levels as well)
If you use an AI, you need to be testing your E2 levels. Driving E2 too far down can be just as bad as having a level that is too high.
AI's are available from non-prescription sources, but be careful what you use and how much you use if you go that route.
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03-30-2012, 07:29 AM #5HRT
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Why did you start a new thread? Don't you already have one going on your current status?
You stated in past posts that you have fixed income and you can't get E2 tested among other things...correct?
BEFORE you start talking about using very powerful antagonists like an AI you need to get blood work done first and foremost.
I suspect from your previous emails that you may have elevated E2 along with possibly higher SHBG.
Do yourself a huge favor before you hurt yourself; get blood work done first.
Get a E2 "sensitive" assay, anything else is useless.
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03-30-2012, 07:34 AM #6
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03-30-2012, 09:07 AM #7Associate Member
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Thanks gdevine. I am trying to be as thorough as possible, which is why I may be asking too many questions.
Sorry about starting another thread, I just wanted to separate the E2 question so the other thread wouldn't get too long. My apologies.
I'm going to try and get a sensitive assay test for E2 done this week, along with tests for SHBG, and BioAvailable Testosterone .
I am definitely going to get BW done before going on an A.I.
I just wanted to know if my E2 levels were still high if I should try and get them down first, or wait to see how the every 3.5 days of injecting the test does with helping to lower them.
I apologize if I asked a stupid question.Last edited by killergoalie; 03-30-2012 at 09:11 AM.
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03-30-2012, 11:28 AM #8HRT
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No stupid questions here my friend!
IMO it would be a big mistake to take an AI before BW.
You need to know your baseline and then AI dosage from there as your starting point.
Get you BW as soon as you can!
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03-30-2012, 12:21 PM #9Banned
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^^ What GD said ^^ Yes
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03-30-2012, 01:24 PM #10Associate Member
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Thanks again, gd, and vette!
Well I just came back from the lab, and according to them, there are no labs in Canada, either independent, or in a hospital, or anywhere that do/perform the sensitive assay Estradiol E2 test. It was clearly specified on the requisition form, along with SHBG, Albumin, and BioAVailable testosterone , but the lab worker told me about the sensitive assay test not being available anywhere in Canada.
But I'll wait to see what the results say.
I may have to try and find a lab in Blaine, Wa. or Bellingham to get the sensitive assay test done.
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