Mild Androgen Insensitivity Syndrome and HRT

[Boba155]

Hi all!

So I was recently diagnosed with MAIS. Here's an abstract which explains the symptoms:

"Impaired spermatogenesis is not an obligate expression of receptor-defective androgen resistance."

Basically it's a condition where even though you produce normal or even high levels of testosterone (I was 680 TT, 15.6 Free) you express many low testosterone symptoms because your receptors respond very poorly to androgens. Growing up I always looked far younger than my age, carried no muscle mass on my body whatsoever (6'2 130 lbs), grew male hair only on my legs and arms (no chest or facial hair) and more, such as a very weak jaw, narrow shoulders, and a high voice.

Surely enough, my doc raised the possibility of MAIS to me when he saw how concerned I was with my masculinity, or rather lack thereof. Surely enough, we performed the genetic testing using a fibroblast sample from me and the test came up red: an extremely reduced affinity for T and DHT.

My doc and I, while both ecstatic that we had isolated the root of all my problems over the last 18 years, were slightly saddened as the only way to truely treat MAIS is with high dose TRT.

So after biting the bullet, I decided to go on high dose TRT (500 mg/wk). Now I understand many of you may think this is a crazy dosage, but please understand that I am a rather unique case.

Here is my question to you all. Is there any way I can use 500 mg Test E for the rest of my life healthily? I am worried about cholesterol and BP, along with heart problems from running such a high dose for so long.

My second question would be the issue of TRT itself. I'm only 18 years old, which means that I would have a VERY long TRT life ahead of me. I would be on shots for the next 65-70 years, which I'm sure to most would be disconcerting. To me, it certainly is. Could anyone who has gone on TRT at a young age as myself possibly PM me their TRT experience? It would mean the world to me!

Thanks all!

[oscar1990]

Boba155, dude how was your diagnosis made and what were the relevant factors involved in determining the MAIS (how was it justified)???

[Boba155]

My doc took a culture of fibroblasts (a cell type with a large androgen receptor population) and then incubated them with DHT and testosterone , along with other androgens, along with a tracer. He then measured the level of AR gene transcription and found it to be VERY low, indicating a very weak affinity for androgens (insensitivity). He performed the test a few time to account for error.

I'll see if I can find the exact protocol for ya.

The reasons for the test was because I raised the possibility of low T to my doc (citing my obvious physical symptoms along with no libido, no energy, low aggression). I came back at around 700 T with good free T and E2 around 30. My doc did a LOT of research for me (he even agreed that I showed a huge amount of low T signs and that it was probably a receptor issue versus a T issue). Surely enough, he recommended I get tested for AIS and I came up positive.

I've never been happier and yet sadder at the same time.

[Sas29]

Hey man, I've been diagnosed with this. How high was your LH? Men with MAIS usually have elevated T and LH levels.

[HRTstudent]

Here is my question to you all. Is there any way I can use 500 mg Test E for the rest of my life healthily? I am worried about cholesterol and BP, along with heart problems from running such a high dose for so long.

I can assure you nobody on this site is qualified to answer this question. Furthermore, anyone qualified to answer this question will not give you a simple "yes".

The best you can do is weigh the potential negatives vs the positives and come to a mutual decision with your physician.

I would be searching pubmed and all medical journals for your specific condition, and look for a doctor who specifically treats your condition. If you're lucky, you will find one you can go to that takes your insurance. Otherwise, read everything you can in the medical literature and make informed decisions with your treating doctor.