A daily dose of a PDE5i and an Alpha Blocker and...

[steroid.com 1]

As some of you may recall, I recently added a small dose of an Alpha Blocker (Doxazosin) to my twice daily low dose use of a PDE5i (Tadalafil/Cialis) to see if it could enhance the quality of my erections.

I was happy to report that it did just that; in fact, I haven't woken in the morning to a serious erection in a few years (just age related nothing more) and wanted to see what would happen when I added in some AB to the PDE5i use.

My protocol is simple: twice daily (once before bed and again in the afternoon) I take 5mg of Tadalafil (Cialis) and 1mg of Alpha Blocker (Doxazosin). My morning erections have not only come back they are strong and rather impressive. I don't know why we men are so taken by waking erections but we are cause we are men and let me tell you how happy it's made me LOL!

Tadalafil has a long half life (~16 hours) compared to other PDE5i's like Viagra and Levitra (~4 to 6 hours) and it enters the blood stream much faster then the other two as well and is not effected by food intake. Doxazosin has about the same half life as the Tadalafil so by taking them both about every 12 hours assures peak serum levels.

What's this mean you may ask?

It means getting and sustaining a serious erection "on demand" is a shit load easier! Many men get performance anxiety when they take a shorter acting PDE5i like Viagra so it can inhibit the effects of the drug...not the effect men are looking for.

Also, there are very nice health benefits for men as well at these low doses such as lowering BP, reducing the effects of BPH and allowing for a healthy urine stream...among other things.

There have not been many, if at all, studies on the effects of combining a PDE5i with and AB but this study came out recently that seems to confirm what I and other men have discovered when these two compounds are co-administered.

I purchase both Tadalafil and Doxazosin from an online pharmacy at very economic prices so it's not cost prohibitive at all.

So, for some of you guys looking for a more robust erection or where you don't get a strong response to a monotherapy use of a PDE5i the combination of a PDE5i and AB may be just the solution you seek.

Full Study: http://www.nature.com/ijir/journal/v.../3900815a.html

Combined oral therapy with sildenafil and doxazosin for the treament of non-organic erectile dysfunction refractory to sildenafil monotherapy

A F De Rose1, M Giglio1, P Traverso1, P Lantieri2 and G Carmignani1

1Department of Urology, S. Martino Hospital, University of Genoa, Italy

2Department of Medical Statistics, S. Martino Hospital, University of Genoa, Italy

Correspondence to: A F De Rose, Via Donato Somma 77, I-16146, Genova, Italy. E-mail: [email protected]


Abstract

The purpose of this work was to investigate the efficacy and safety of sildenafil in combination with doxazosin for the treatment of non-organic erectile dysfunction in patients who did not respond to sildenafil. We enrolled 28 patients with non-organic erectile dysfunction, for whom 3 months of sildenafil monotherapy had failed. They were divided in two random and homogeneous groups: 14 were treated with doxazosin (4 mg daily) and sildenafil (100 mg 1 h before sexual intercourse); the other 14 patients received sildenafil and placebo. The results were assessed by means of the IIEF questionnaire before the beginning of the study, after 30 days of therapy and after 60 days. Of the 14 patients treated with doxazosin and sildenafil, 11 (78.6%) showed a statistically significant increase of IIEF; in the placebo group, only one patient (7.1%) recorded a significant IIEF increase. The differences observed in the two groups were statistically very significant (P=0.0016). Blood pressure did not show significant alterations. Side effects were minimal and even present during sildenafil monotherapy. The combination therapy with sildenafil and doxazosin resulted in the safe and effective treatment of men with non-organic erectile dysfunction for whom sildenafil alone had failed.

International Journal of Impotence Research (2002) 14, 50-53. DOI:

[SEOINAGE]

Do you notice much changes in maintaining an erection after ejaculation? mid 20s I could go all night if I wanted, even on trt I can't even dream of that. I know it's a little unrelated to the study, but from your experience with it, what should ones expectations be anyways.

[steroid.com 1]

Not with this combo but when I added in a little Cabergoline to the protocol that did the trick in shortening the refractory period and increasing libido Seoinage.

[Vettester]

Yeah, I can vouch that it's an effective protocol, as I do something very similar. I haven't had any caber in awhile, but there's some sitting in the cabinet just waiting to go to town!

[kelkel]

Nice post GD!

Vette, you were just in Vegas. The caber didn't make the trip? WTF.

[Vettester]

Nice post GD!

Vette, you were just in Vegas. The caber didn't make the trip? WTF.

Ha ha ... Actually that party ended up in LA for a night, so my wife and I kept it closer to home. That's been about a month ago, which was probably the last time I had some caber. I think it's time for some more

[Times Roman]

I dunno Gdivine

I've been following your advice, and it's a bitch trying to take a leak in the morn with a flag pole that wont' go to half mast!

havne't tried caber.

tell me more mr. wizard?

[O40]

Interesting read. If i find if I have an erection at an inopportune time, a little thump to the head drops him back down to manageable.

[kelkel]

^Which head? And I'm still searching for the inopportune time!

You'll like Caber TR. Read this: http://forums.steroid.com/showthread...e-Caber-Thread

[Brazensol]

Interesting read. If i find if I have an erection at an inopportune time, a little thump to the head drops him back down to manageable.

That's no way to treat your best friend...even if he is being a bit unruly! lol.

[steroid.com 1]

TR - Good read. I can only tell you from my own experience that .25mg of Dostinex (Cabergoline) twice a week on injection days has had a nice impact on libido but more importantly orgasm is greatly enhanced and refactory period significanlty decreased. May not have the big shot like PT-141 but for an ongoing protocol Dostinex is hard to beat...plus it has many health benefits for men as well.

Sex and Cabergoline

By David Jay Brown

Cabergoline is a fairly new pharmaceutical that has enormous potential to aid male stamina. Perhaps the most remarkable aspect of carbergoline is that it has been found to substantially raise a man’s chances of sustaining multiple orgasms during sex. Some men on cabergoline are able to have numerous multiple orgasms in rapid succession.

Cabergoline, which is marketed under the trade name of Dostinex, is used to treat Parkinson's disease, to prevent women producing milk when they want to stop breast feeding, and to lower prolactin levels in patients with a pituitary tumor. It is also sometimes used to help men with sexual dysfunction.

It is cabergoline’s capacity to lower prolactin levels that makes it such a sexual wonder drug for men. Prolactin is a single-chain protein hormone, closely related to growth hormone , that stimulates the secretion of milk of women. The hormone also has the effect of reducing a man’s desire for more sex by preventing new erections. Cabergoline has been found to to minimize the effects of the hormone prolactin, which is produced by men at the point of orgasm. As a result, some subjects who tried the drug found that they were able to have multiple orgasms in rapid succession.

In one study, 60 subjects, all healthy males, between the ages of 22 and 31, normally needed a break of 19 minutes between lovemaking sessions. However, after taking Cabergoline, they were able to have several orgasms within a few minutes. Medical psychologist Manfred Schedlowski, who was involved in the trials at Essen in Germany, said the drug raised the libido to enable the male to orgasm again more quickly.

Schedlowski said, "We saw that prolactin rises after orgasm and then thought maybe prolactin is a negative feedback system. Subjects who took this drug had decreased prolactin levels, and reported their orgasm was better and there was a shorter refractory period. We interviewed these subjects and found they were able to have multiple orgasms in very rapid succession. This is sitting very nicely with our hypothesis that orgasms and sexual drive are steered by prolactin and dopamine in the brain."

Cabergoline was reported to have no side effects on men during the tests, according to a paper that was published in the International Journal of Impotence Research. However, there may be a drawback. There’s evidence that the release of prolactin in the brain, which surges during orgasm, promotes the growth of new neurons in the brain--a process called neurogenesis. Researchers at the University of Cal-gary discovered that the release of prolactin spurs the growth of new brain cells in the front regions of the brain involved in smell. So Cabergoline may allow men to have multiple orgasms at the expense of
less brain growth. Sounds like a tough call to me.

Researchers are carrying out trials to investigate whether Cabergoline will have similar effects on women. Some anecdotal reports suggest that the drug has the potential to enhance the intensity of orgasms in both men and women.

[O40]

That's no way to treat your best friend...even if he is being a bit unruly! lol.

Well, if I pop 30 MGs of pharm grade Cialis, 300 IUS of HCG and my HRT dose with a little extra prop, I am popping wood 24 X 7.

Gdevine:

I have some dostinex from the pharmacy and when I took it it was like a running a line of coke. I picked it up when I was using Tren for prolactin sides. I did read where depending on dose and duration it might cause some heart valve damage? I remember having sex w my wife, getting a nut and no loss of erection, but I couldn't get another nut and she made me stop. She was a little freaked out by it. I remeber being anxious as well a couple hours after taking it. I think I have 6 more 4 mg tabs left but they are probably 5 years old, probably still OK, I recall it does not do well with light or moisture. I also played with PT 141 and that stuff will give you a full on steel pipe boner.