ARGH! Pregnenolone makes me wired!!!

[sparverius]

Two days of taking a 10mg pill in the morning and I'm completely wired. I couldn't sit still last night. Didn't get much sleep.

This is the second time I've tried it and the second time this has happened, so I know its the Pregnenolone.

Is this normal? The typical dose listed in the sticky thread is 50-200 mg. I'd explode if I tried that!

[steroid.com 1]

Yes, it can have this effect on some people and is usually a sign you were possibly deficient or low in serum level.

Both Pregnenolone and DHEA can act as a stimulant till the body adjusts to it.

But I do have to say that 10mg is already a low dosage amount.

What I'd recommend is to titrate your dosage; a practice used with many drugs by physicians and healthcare providers.

What this means is start with a much lower dose like cutting that 10mg pill into 4 - 2.5mg pieces and start with that daily. In about 10 to 14 days add another 2.5mg and repeat till you reach the dosage amount.

Your body just needs to acclimate and titration is the methodology that will do just that.

[juice2012]

Wow I wish I could take something that would give me energy that isn't a ritalin. I'll have to try this soon.

[steroid.com 1]

Juice - He's an over-responder; it happens but not to most.

Don't count on this happening to you.

You want to get fired up?

Try some Yohimbine, that will fire you up

[juice2012]

Juice - He's an over-responder; it happens but not to most.

Don't count on this happening to you.

You want to get fired up?

Try some Yohimbine, that will fire you up

Wow i've never heard of this stuff. Learn something new everyday, especially from you guys here. I started reading about some of the side effects though.

Some effects in rare cases were panic attacks, hallucinations, headaches, dizziness, and skin flushing.
Yohimbine should not be consumed by anyone with liver, kidney, heart disease, or a psychological disorder.

I'm too scared to try it now, I don't need any more panic attacks!!

[dreadnok89]

ya i hear you juice. there awful

[SEOINAGE]

wow I must be a serious under responder, because I took 100 mg of each from the get go and didn't feel a thing, and have taken every day since and nothing pronounced, but overall I feel pretty good. Still get sleepy during the day like right at this moment I want a nap, but been up since 4 am. I haven't felt any of those symptoms yet.

[J DIESEL3]

Good to know all of this...

I have not started the Pregnenolone yet but i did take 50mg per day DHEA and had problems.

Man did i have really bad anxiety and feel like i was speeding as well.

I just picked up that 100mg per ml DHEA and pregnenolone cream and really want to try it.
I am just very nervous about feeling like i did before however i think it would be very good to add them.

[steroid.com 1]

Guys - If you over respond it's best to start with tolerable dosages and then titrate up over time.

Your body just needs to acclimate to the hormone being introduced.

Both Preg and DHEA are very very good for you on a TRT protocol.

[juice2012]

When I try DHEA I'm probably going to start with just 25mg a day and see where that lands me. Anxiety is always an issue for me too.

[steroid.com 1]

For guys who have anxiety issues have you ever had SHBG and Cortisol tested (adrenals)?

[juice2012]

SHBG taken after 6 weeks of TRT:
SexHormone Bind Glob 9.83 10 - 57 Flagged as low

Taken before TRT in the morning while fasting:
Cortisol, AM Level 19.8 5.0 - 25.0

[steroid.com 1]

SHBG taken after 6 weeks of TRT:
SexHormone Bind Glob 9.83 10 - 57 Flagged as low

I am willing to bet you a free night at "The Cheta" that this is the root cause of your anxiety.

SHBG buffers our nervous system from the serum fluctuations we get when we inject Testosterone into our bodies.

When your SHBG serum level is low and Testosterone levels fluctuate on weekly or even twice weekly Testosterone injections this will/can cause anxiety in men (it can't buffer the physiological effects of the spikes).

One way to get around this is to inject lower doses of Testosterone SQ EOD (or even ED) to get a more steady serum level (think small zig zags) as opposed to the larger spikes we see in weekly or twice weekly injections.

Have you had your Thyroid tested? Under performing Thyroid can cause suppression in SHBG levels.

Take note guys, SHBG is very important and is best in the mid of the reference range for all men.

[J DIESEL3]

My SHBG came in at 19 range also 10-57.

I don't remember what my cortisol is and will check that when I get home as well.

Also I will need to get a full thyroid blood work done very soon being all my doc checked was tsh...That came in at 2.43

Thanks gd!

[juice2012]

SHBG taken after 6 weeks of TRT:
SexHormone Bind Glob 9.83 10 - 57 Flagged as low

I am willing to bet you a free night at "The Cheta" that this is the root cause of your anxiety.

SHBG buffers our nervous system from the serum fluctuations we get when we inject Testosterone into our bodies.

When your SHBG serum level is low and Testosterone levels fluctuate on weekly or even twice weekly Testosterone injections this will/can cause anxiety in men (it can't buffer the physiological effects of the spikes).

One way to get around this is to inject lower doses of Testosterone SQ EOD (or even ED) to get a more steady serum level (think small zig zags) as opposed to the larger spikes we see in weekly or twice weekly injections.

Have you had your Thyroid tested? Under performing Thyroid can cause suppression in SHBG levels.

Take note guys, SHBG is very important and is best in the mid of the reference range for all men.

I've had OCD since I was a small child and later on panic attacks in my 20s. I CANNOT smoke weed, or do any drugs that aren't downers without getting anxiety or panic attacks. I've been on SSRIs, anti-anxiety drugs, and pretty much anything else you can think of. As of right now I haven't been on any psych meds for over 3 years.

When I got my first 100mg T injection I had a strong anxiety / mild panic attack 2 days after the injection, and had mild anxiety continuing for almost a week. After I split my injection and got settled in I went back to "normal". Day to day I don't really deal with anxiety. But even a low dose of ritalin that I sometimes take for fatigue will give me mild anxiety, it sucks.

Here are the results of my thyroid tests, all pre-TRT:

Free T3 4.18 2.3 - 4.2
Free T4 1.02 0.59 - 1.61
TSH 2.75 0.34 - 4.82

[steroid.com 1]

^^^^Thyroid is fine.

Your SHBG is tanked and needs to come up.

Try adding in some Pregnenolone to your supplements as well juice; look for micronized pills...50mg in the am daily.

[juice2012]

^^^^Thyroid is fine.

Your SHBG is tanked and needs to come up.

Try adding in some Pregnenolone to your supplements as well juice; look for micronized pills...50mg in the am daily.

How do I bring SHBG up with out lowering my T?


Check out these, both on the lower range:
Pregnenolone 41 13 - 208
DHEA SULFATE 164 110 - 510

I'll be ordering micronized version of both tonight on Amazon.

[steroid.com 1]

How do I bring SHBG up with out lowering my T?


Check out these, both on the lower range:
Pregnenolone 41 13 - 208
DHEA SULFATE 164 110 - 510

I'll be ordering micronized version of both tonight on Amazon.

Juice - Start a new thread...we've hyjacked this one bad enough already LOL!

Sorry OP!

[juice2012]

Hah true. Sorry bro! At least it's getting bumped lol

[kelkel]

Op, like G said, titration works here. Same thing happened to me with the anxiety and I've never experienced that before (remember talking about that G?) so I took a few days off, restarted low and worked my way up. All good! You'll be fine.