Aspirin and hCG - Bad mix?

[Sworder]

Thought this was an interesting study and I wanted to share it. Basically the study states that they found a statistically significant difference with aspirin + hCG administration versus placebo + hCG. Full text available, read it!


Aspirin inhibits androgen response to chorionic gonadotropin in humans
http://ajpendo.physiology.org/content/277/6/E1032.full

Abstract

Eicosanoids play an important role in the regulation of the hypothalamic-pituitary axis; less clear is their role in testicular steroidogenesis. To evaluate the involvement of cyclooxygenase metabolites, such as prostaglandins, in the regulation of human testicular steroidogenesis, we examined the effects of a prostaglandin-blocker, aspirin, on plasma testosterone , pregnenolone, progesterone, 17OH-progesterone, androstenedione, dehydroepiandrosterone, and 17β-estradiol response to human chorionic gonadotropin (hCG) in normal male volunteers in a placebo-controlled, single-blinded study. To test the efficacy of aspirin, seminal prostaglandin E2 levels were also determined. hCG stimulation increased peripheral levels of testosterone , 17OH-progesterone, androstenedione, dehydroepiandrosterone, and 17β-estradiol, without affecting circulating pregnenolone and progesterone values. Aspirin significantly lowered seminal prostaglandin E2levels, whereas it did not modify steroid concentrations not exposed to exogenous hCG. Moreover, the drug significantly reduced the response of testosterone, 17OH-progesterone, androstenedione, and dehydroepiandrosterone to hCG, as assessed by the mean integrated area under the curve, whereas it did not influence 17β-estradiol response. In conclusion, aspirin treatment inhibits androgen response to chorionic gonadotropin stimulation in normal humans. The action of aspirin is probably mediated via an effective arachidonate cyclooxygenase block.

[kelkel]

Interesting find, and I spend way too much time on those type sites. That is a large percentage drop from the placebo group. Long read but noteworthy. It won't stop me from taking my baby aspirin at bedtime but for larger and longer dosed protocols it will make me think twice.

kel

[Sworder]

It's a good example of drugs that have effects we are oblivious to. This is why I believe that the less drugs we take, the better. Often in context to HRT and the use of aromatase inhibitors.

It really worries me thinking about these things. Not to the point where it brings me anxiety, but more like looking in the night-sky while touching my chin, pondering...

[kelkel]

I'm thrilled that I do not need an AI and consider myself fortunate due to the relatively unknown long-term effects. When it comes to the study in question, I would have loved to see a broader range of doses (aspirin) and their related impact. In other words, do the larger doses exponentially increase the negative impact on HCG and do smaller, minimal doses have little to no impact on it?

[Sworder]

As most drugs are dose-dependent, I would envision a linear relationship between these two as well. Of course 800mg aspirin's effect will probably be at the top-end, baby aspirin(80mg) probably won't yield statistically significant changes.

[kelkel]

Hoping for barely a bump on the negative scale.