Progesterone / Pregnenolone / Prolactin

[Allaaro]

Hey all, was hoping for some info for TRT'ers and Progesterone / Pregnenolone / Prolactin.

First question, who all supplements with pregnenolone, or progesterone?

I was going to bring up to my doc to test pregnenolone/progesterone. If I'm taking caber, would this effect my levels? I know prolactin would be lower, but other 2 lower also?

This is one area in TRT that I could use some more research on, so any links/articles would be great.

I'm already supplementing DHEA so just looking at some other options for feeling the best overall.

Thanks

[HRTstudent]

When I took "enough" pregnenolone I saw my progesterone levels skyrocket.

I took less and it came down. My prolactin levels were unaffected as far as I'm concerned.

I've heard some people take progesterone, but its not that common. Heck, pregnenolone isn't even that common I think. But the thing with progesterone (to me) is that it can have estrogenic effects on its own when it comes to gyno... so I don't really care to tinker with it. But beyond that, I've never seen anything that says it might be worthwhile to bring it higher. if I did... I imagine id just take more pregnenolone though.

If you're interested in pregnenolone, then bring it up with your doctor and try it out. Its pretty cheap, but there are so many brands and formulas out there that you might want to trial a couple. Oral pregnenolone has quite a reputation as being particularly good for anxiety.

[HRTstudent]

I was just looking over something and thought of this thread... It is from Dr Mariano in 2012:

Progesterone is an antiinflammatory signal in the brain. It's daughter signal allopregnanolone is another important antiinflammatory signal. Progesterone also works through the GABA signal system to reduce norepinephrine signaling helping reduce anxiety, stress, and seizures.

The problem with progesterone is that it is a precursor (can be converted) to other hormones which can cause a cascade of events leading to the opposite effect.

For example, progesterone can be converted to the estrogens. It increases receptors for the estrogens, making one more sensitive to estrogen. The estrogens can promote aggression, anxiety, and inflammatorhy signaling if in excess. They can also reduce available thyroid hormone - leading to fatigue, increased anxiety. Both effects can lead to panic attacks.

[GotNoBlueMilk]

Hmmm, estrogens can promote aggression. Interesting info.

[Allaaro]

Thanks for the info.

With caber, prolactin and progesterone should be able to be controlled on the lower side. Then adding Progesterone if needed might help overall and keep other 2 low at same time but still in range since I think progesterone most important than other 2.

All just guessing really until I get bloodwork done, but I'll bring it up to test anyway.