Changes in pituitary function with ageing and implications for patient care

[steroid.com 1]

Great article by one of the top experts on hormone loops. One needs to appreciate the complexity of the male hormonal system to understand the end result of Testosterone and DHT on our bodies and how the Pituitary and Hypothalamus are so critical in the HPT loop.

Changes in pituitary function with ageing and implications for patient care

Johannes D. Veldhuis

Abstract
The pituitary gland has a role in puberty, reproduction, stress-adaptive responses, sodium and water balance, uterine contractions, lactation, thyroid function, growth, body composition and skin pigmentation. Ageing is marked by initially subtle erosion of physiological signalling mechanisms, resulting in lower incremental secretory-burst amplitude, more disorderly patterns of pituitary hormone release and blunted 24 h rhythmic secretion. Almost all pituitary hormones are altered by ageing in humans, often in a manner dependent on sex, body composition, stress, comorbidity, intercurrent illness, medication use, physical frailty, caloric intake, immune status, level of exercise, and neurocognitive decline. The aim of this article is to critically discuss the mechanisms mediating clinical facets of changes in the hypothalamic–pituitary axis during ageing, and the extent to which confounding factors operate to obscure ageing-related effects.

http://www.nature.com/nrendo/journal...o.2013.38.html

[jimmyinkedup]

Can anyone access the full paper? Id love to read more. Great post Gdev!

[steroid.com 1]

Getting it now my friend. Sit tight...

[steroid.com 1]

Ok, I have the article and it's freaking great! In fact, it should be a sticky it's so good.

If you want a copy IM me your email account and I will send to you.

It's a PDF and I can't upload it here.

[jimmyinkedup]

I tlooked like a great read. Pm sent buddy.

[jimmyinkedup]

Ok, I have the article and it's freaking great! In fact, it should be a sticky it's so good.

If you want a copy IM me your email account and I will send to you.

It's a PDF and I can't upload it here.

TY Gdev. This is a must read. We need to figure out a way to get it here for sure! Great find!

[georgekonis]

I would be very interested in reading that pdf. I was thinking about going to the mayoclinic to be seen by dr Veldhuis.

I have a sluggish pituitary. Normal semen analysis, low testosterone , average Lh. My LH should be higher to compensate for the low Testosterone . I'm still planning on having kids and I'm not a candidate for testosterone replacement . I have never done steroids .
I would like to see if the Dr. has any recommendations besides the standard clomid.

Does he mention any ********** protocols in his paper?

[georgekonis]

I'm sorry I forgot to ask if you could be so kind and email me that pdf.

george at mmtmpartners dot com

[2Sox]

TY Gdev. This is a must read. We need to figure out a way to get it here for sure! Great find!

I agree. If you could get it onto the forum for everyone to benefit from, it would be a great gesture.

[APIs]

Old thread. OP was banned some time ago...

[2Sox]

Old thread. OP was banned some time ago...

Thanks. I was aware of this but if I paid attention to the posting date, I wouldn't have been left scratching my head about how this thread got here.