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  1. #1
    m_donnelly is offline Associate Member
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    TRT and depression/anxiety

    Has anyone experienced an increase in anxiety or depression on TRT? I've heard and read conflicting reports.

  2. #2
    jomamma007 is offline Member
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    Quote Originally Posted by m_donnelly View Post
    Has anyone experienced an increase in anxiety or depression on TRT? I've heard and read conflicting reports.
    I believe most who still suffer from anxiety aren`t supplementing with pregnenolone and dhea. I'm only 2 weeks into my protocol but I'm already feeling better, could say it's placebo but 400mg`s in I doubt it.

  3. #3
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    It can happen and does happen; not a lot, but it does. Drs. Morgan and Crisler, among others, will supplement with DHEA and Pregnenolone as they can be at lower levels when on TRT and cause some anxiety. When supplemented many men claim of feeling much better and even increase libido.

    Look for micronized versions of both and get the Pregnenolone in 50 mg and the DHEA in 25 mg. Take the Pregnenolone and one 25 mg of the DHEA in the morning and the other 25 mg of DHEA in the afternoon.

    You would need a complete hormonal workup done to rule out other possible issues like Thyroid conditions which can cause anxiety as well.

  4. #4
    Moparman's Avatar
    Moparman is offline Associate Member
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    Isn't anxiety a side effect of high estrogen?

  5. #5
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    Quote Originally Posted by Moparman View Post
    Isn't anxiety a side effect of high estrogen?
    Yep...and low too.

  6. #6
    HRTstudent's Avatar
    HRTstudent is offline HRT Specialist ~ Knowledgeable Member
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    I felt depressed when my doctor (stupidly) suggest I come off TRT cold turkey and my estradiol at the time was above range. Bad combo!

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