High PSA-endo to stop my TRT!

[w8liftr]

Been on trt for just over 2 years; 200 mg T Cyp e2w. Last November I convinced doc to up to 400 e2w. He did so with condition I see endo to get confirmation this is ok. Saw endo Last week (took 5 months to see her) and she ordered blood work. Got results yesterday and psa was 7.6, where high range is 4. She recommended stopping trt and get psa taken again to rule out bad test. T-test was 350 and estradiol was little over mid range at 43.
I suggested not to stop trt suddenly but should have some kind of restart protocol. She said no. I have a month supply left and will wean off of trt and troubleshoot high psa in the meantime. While on 400 e2w ( actually injected once a week) my total estrogen went to 120, where upper range is 115. Doc didn't order the e2 sensitive test at that time. Total t at that time was only 600. T was aromatizing to e. don't have any AI.
Question is; can high estrogen cause elevated psa?
Anything I can do to lower psa ( assuming its not cancer and is a little infection or an anomaly )?
What's the best protocol to wean off trt and jump start own production of hormones?
If my psa doesn't come down dox will shut me off and I will crash.
Appreciate any comments, suggestions.

[100%]

You need to get a Digital Rectal Examination (DRE) ASAP.

A recently published study showed that both omega 3 fats and Coenzyme Q10 may help prostate health. In the study, 504 healthy men aged 40 to 70 with prostate-specific antigen (10) levels < 2•5 nanograms/milliliter were given one of the following per day for 12 weeks:
Omega-3 fatty acids (4.48 grams of EPA and 2.88 grams of DHA = 126 patients)
Omega-6 fatty acids (2,400 milligrams of Gamma-linolenic acid = 126 patients)
CoQ10 (400 milligrams = 126 patients)
Placebo = 126 patients

By the end of 12 weeks, those in the EPA/DHA group saw their prostate-specific antigen levels significantly fall by 30% . This compared to a 15% increase in the gamma-linolenic acid group and a 33% drop in the Coenzyme Q10.

No data is available for a EPA/DHA+ COnezyme Q10 combination.




Reference:
Br J Nutr. 2012 Nov 30:1-8. [Epub ahead of print]
Effects of EPA, γ-linolenic acid or coenzyme Q10 on serum prostate-specific antigen levels: a randomised, double-blind trial.
Safarinejad MR, Shafiei N, Safarinejad S.
Source
Clinical Center for Urological Disease Diagnosis and Private Clinic Specialized in Urological and Andrological Genetics, PO Box 19395-1849, Tehran, Iran.
Abstract
The main objective of the present study was to determine the potential of n-3 and n-6 fatty acids or coenzyme Q10 (CoQ10) to alter serum prostate-specific antigen (PSA) levels in normal healthy men. A total of 504 healthy men with serum PSA level ≤ 2·5 ng/ml were recruited into the study. Serum PSA values were not segregated by decade of age. Participants were randomly assigned to a daily dietary supplement containing n-3 fatty acids (1·12 g of EPA and 0·72 g of DHA per capsule) (group 1, n 126), n-6 fatty acid (600 mg γ-linolenic acid (GLA) each capsule) (group 2, n 126), CoQ10 (100 mg per capsule) (group 3, n 126) or a similar regimen of placebo (group 4, n 126) for 12 weeks. Study medication was administered as two capsules to be taken twice daily. Serum levels of PSA, EPA, DHA, GLA, lipid profile and reproductive hormones were also measured. EPA treatment significantly reduced serum PSA level by 30·0 (95 % CI 25, 36) % (P = 0·004) from baseline. In contrast, GLA therapy significantly increased serum PSA concentration by 15·0 (95 % CI 11, 20) % (P = 0·02). CoQ10 therapy also significantly reduced serum PSA level by 33·0 (95 % CI 27, 40) % (P = 0·002). In multivariable analysis, serum values of PSA were strongly correlated with duration of EPA (r - 0·62; 95 % CI - 0·42, - 0·77; P = 0·003), n-6 (r 0·42; 95 % CI 0·31, 0·58; P = 0·02) and CoQ10 use (r - 0·77; 95 % CI - 0·56, - 0·87; P = 0·001). There were also significant correlations between serum values of DHA, EPA, GLA and CoQ10 and serum PSA levels. The present study demonstrates that dietary supplements containing EPA, GLA or CoQ10 may significantly affect serum PSA levels.
Posted by Nelson Vergel at 1:46 PM
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Labels: coenzyme q-10, DHA, EAP, lower PSA naturally, Omeg-3, Omega-6, prostate supplements, protect prostate with supplements, PSA, supplements
Reactions:

[kelkel]

You also need a doctor that understands hormones. Yours are absolutely clueless and they will end up harming you.

[100%]

I would not worry to much about crashing your hormones. You have been doing that every two weeks with your protocol. Eno is right you have to stop trt till certain things can be ruled out you could be adding fuel to the fire.

[bullshark99]

I agree on all fronts, your Endo was doing you no favers with the protocol you are on. not to be offensive but its kind of ridiculus really, you must of been on a roller coaster. Anyway to your point, I would defenitly stop as tes is like putting gasoline on fire if one HAS cancer already.
Now before you start freaking out there are many things that can elevate PSA, specifically an infection, google it, somewhat common. That being said, 7 is nothing to take lightly. Go see a urologist and get a DRE and also a ultrasound and byopsy. Pain in the ass but logically what else are you gonna do, burry your head in the sand and ignore it?
Best of luck, keep us posted.

[powerlifterty16]

Pain in the ass but logically what else are you gonna do, burry your head in the sand and ignore it?
Best of luck, keep us posted.

lol..

[MuscleInk]

Yes, estrogen(s) correlate with prostate health, more so in fact than other circulating androgens do. Unfortunately, the most common clinical protocol when PSA elevates during TRT, is to stop all hormone therapy including any HCG or PCT that would otherwise make for a gradual and more pleasant "restart". The reason behind this is quite simple: your doctor is stoping all hormone replacement to see if the PSA drops correspondingly and does not wish to confound the response with other hormones (HCG, tamoxifen , clomiphene). It is rather unpleasant for the patient but deemed necessary by the MD to evaluate PSA response.

A transrectal ultrasound (TRUS) is far more definitive of prostate morphology than a DRE as a DRE cannot provide proper evaluation of the superior region of the prostate gland.