Hypermetabolism of Testosterone and Hyperexcretion?

[BallSak]

180 mg of Test Cyp per week gets my total T in the upper 500's and my free T to mid-range 4 days post injection. I really want to see what the upper quartile feels like without having to inject 250-300 mg of testosterone . My doc thinks I may just have a lower number of androgen receptors. It's quite frustrating. I started at 100 mg per week (50x2) and have worked my way up to now 200 mg/week over the course of 6 months. TT has stayed in the 500s regardless of dose (100mg, 140mg, 160mg, 180mg) per week.

Perhaps I'm a hyperexcreter. No urine tests to confirm though and I'm not sure anything could be done about it anyway.

Does anyone else have to take a high dose to get your T numbers up?

Can anything be done to upregulate androgen receptors?

I would REALLY appreciate insight from anyone with experience with this.

[dreadnok89]

WhTs your estrogen? I had that problem and an AI freed up a lot of my test and made my free test a lot higher

[BallSak]

WhTs your estrogen? I had that problem and an AI freed up a lot of my test and made my free test a lot higher

I have pretty low estrogen naturally. It finally rose to the mid 40s and I now take .5 mg anastrozole once a week. I'm not converting much and my SHBG was 27 last time I checked. Free T to total T ratio is pretty good so my SHBG should still be good.

[APIs]

My Doc said he has a couple patients like this. He said one of them actually goes thru 2 vials a month to stay in the 800's. He had to verify it through in-office injections and prolonged blood work to cover his own ass he said...

[SEOINAGE]

Yep I would look at e2 first, since it sounds like its dumping somewhere. Even as a hyper excreter myself it just means you take more, doesn't mean half the dose will give you same numbers. I went to an eod injection schedule as well, and it seems to work well, I am on 200 mg a week. I could suggest a more frequent dose can help as well. At minimum twice a week. also do you have other blood work numbers like dht?

[kelkel]

Yep I would look at e2 first, since it sounds like its dumping somewhere. Even as a hyper excreter myself it just means you take more, doesn't mean half the dose will give you same numbers. I went to an eod injection schedule as well, and it seems to work well, I am on 200 mg a week. I could suggest a more frequent dose can help as well. At minimum twice a week. also do you have other blood work numbers like dht?

I'd be curious about this as well. Op, remember test converts to DHT everywhere in the body except skeletal muscle.

[BallSak]

Yep I would look at e2 first, since it sounds like its dumping somewhere. Even as a hyper excreter myself it just means you take more, doesn't mean half the dose will give you same numbers. I went to an eod injection schedule as well, and it seems to work well, I am on 200 mg a week. I could suggest a more frequent dose can help as well. At minimum twice a week. also do you have other blood work numbers like dht?

E2 stays around 20-30. I inject every 3.5 days. No, I've never had DHT checked...I will next time.

[BallSak]

My Doc said he has a couple patients like this. He said one of them actually goes thru 2 vials a month to stay in the 800's. He had to verify it through in-office injections and prolonged blood work to cover his own ass he said...

There's got to be something that could be done to fix this...I would think.

[BallSak]

I'd be curious about this as well. Op, remember test converts to DHT everywhere in the body except skeletal muscle.

Curious why you ask? I do also take 15mg progesterone at bedtime. I'm not completely sure how it affects dht but I believe they compete for the same receptor.

[The Deadlifting Dog]

How much do you weigh?

[BallSak]

How much do you weigh?

6'0 203 lbs, body fat in the low to mid teens

[The Deadlifting Dog]

Was curious because the heavier someone is the more blood they have. The more blood they have the larger a dose is needed to obtain a certain concentration of testosterone in their system.

I thought that perhaps you were 300+ lbs.

[BallSak]

Was curious because the heavier someone is the more blood they have. The more blood they have the larger a dose is needed to obtain a certain concentration of testosterone in their system.

I thought that perhaps you were 300+ lbs.

Yes that certainly would make more sense.