Potential clinical applications of trenbolone

[100%]

This should be interesting!
Tissue selectivity and potential clinical applications of trenbolone (17beta-hydroxyestra-4,9,11-trien-3-one): A potent anabolic steroid with reduced androgenic and estrogenic activity.
Yarrow JF, McCoy SC, Borst SE.
Source
Geriatric Research, Education & Clinical Center, VA Medical Center, Gainesville, FL 32608, United States. [email protected]
Abstract
Recently, the development of selective androgen receptor modulators (SARMs ) has been suggested as a means of combating the deleterious catabolic effects of hypogonadism, especially in skeletal muscle and bone, without inducing the undesirable androgenic effects (e.g., prostate enlargement and polycythemia) associated with testosterone administration. 17beta-Hydroxyestra-4,9,11-trien-3-one (trenbolone; 17beta-TBOH), a synthetic analog of testosterone, may be capable of inducing SARM-like effects as it binds to androgen receptors (ARs) with approximately three times the affinity of testosterone and has been shown to augment skeletal muscle mass and bone growth and reduce adiposity in a variety of mammalian species. In addition to its direct actions through ARs, 17beta-TBOH may also exert anabolic effects by altering the action of endogenous growth factors or inhibiting the action of glucocorticoids. Compared to testosterone, 17beta-TBOH appears to induce less growth in androgen-sensitive organs which highly express the 5alpha reductase enzyme (e.g., prostate tissue and accessory sex organs). The reduced androgenic effects result from the fact that 17beta-TBOH is metabolized to less potent androgens in vivo; while testosterone undergoes tissue-specific biotransformation to more potent steroids , dihydrotestosterone and 17beta-estradiol, via the 5alpha-reductase and aromatase enzymes, respectively. Thus the metabolism of 17beta-TBOH provides a basis for future research evaluating its safety and efficacy as a means of combating muscle and bone wasting conditions, obesity, and/or androgen insensitivity syndromes in humans, similar to that of other SARMs which are currently in development.
Published by Elsevier Inc.
PMID: 20138077 [PubMed - indexed for MEDLINE]
Tissue selectivity and potential clinical applicati... [Steroids. 2010] - PubMed - NCBI

[Metalject]

It's not potential it's more than possible or rather a better way to say it would be it was used therapeutically for more than 30yrs and with an extremely high rate of success in the past.

Parabolan (Trenbolone Hexahydrobenzylcarbonate) was a pharmaceutical Human Grade Trenbolone compound used for more than three decades for the purposes of:

*Malnutrition
*Osteoporosis
*Cachexia

It was used successfully in these areas for a long time and was promising in many others, but due to the ease of access of Trenbolone due to its use in livestock, and the corresponding war on steroids , the pressure that Negma (maker of Parabolan) felt was just too much and it disappeared from the pharmacy shelves.

[100%]

It's not potential it's more than possible or rather a better way to say it would be it was used therapeutically for more than 30yrs and with an extremely high rate of success in the past.

Parabolan (Trenbolone Hexahydrobenzylcarbonate) was a pharmaceutical Human Grade Trenbolone compound used for more than three decades for the purposes of:

*Malnutrition
*Osteoporosis
*Cachexia

It was used successfully in these areas for a long time and was promising in many others, but due to the ease of access of Trenbolone due to its use in livestock, and the corresponding war on steroids, the pressure that Negma (maker of Parabolan) felt was just too much and it disappeared from the pharmacy shelves.

Agreed looks like someone believes there is now money to be made.

[bass]

Agreed looks like someone believes there is now money to be made.

you nailed it 100%!

[kelkel]

Here's a long one for you as well re Tren :

http://ajpendo.physiology.org/conten.../E650.full.pdf

Here's the summary:

In conclusion, administration of TREN, a potent non-5α reducible and non-estrogenic
synthetic testosterone analogue, produces robust myotrophic effects, partial inhibition of bone
loss, prevention of visceral fat accumulation, and maintenance of Hgb and prostate mass at the
level of intact animals, at least at the lowest dose administered. These results suggest that lower
dose TREN induces favorable SARM-like effects on musculoskeletal tissue and adiposity, and
within specific accessory sex-organs. Future research examining the safety and efficacy of this
androgen in pre-clinical settings appears appropriate because the anabolic :androgenic ratio
appears higher and because the risk/benefit ratio appears less than that of supraphysiologic TE, at
least in regards to prostate enlargement; although, evaluating TREN and other SARMs in models
of androgen responsive prostate cancer are necessary prior to recommending these agents for
clinical testing.

[100%]

Here's a long one for you as well re Tren :

http://ajpendo.physiology.org/conten.../E650.full.pdf

Here's the summary:

In conclusion, administration of TREN, a potent non-5α reducible and non-estrogenic
synthetic testosterone analogue, produces robust myotrophic effects, partial inhibition of bone
loss, prevention of visceral fat accumulation, and maintenance of Hgb and prostate mass at the
level of intact animals, at least at the lowest dose administered. These results suggest that lower
dose TREN induces favorable SARM-like effects on musculoskeletal tissue and adiposity, and
within specific accessory sex-organs. Future research examining the safety and efficacy of this
androgen in pre-clinical settings appears appropriate because the anabolic :androgenic ratio
appears higher and because the risk/benefit ratio appears less than that of supraphysiologic TE, at
least in regards to prostate enlargement; although, evaluating TREN and other SARMs in models
of androgen responsive prostate cancer are necessary prior to recommending these agents for
clinical testing.

Thanks for this! I have what looks like the rough draft of this one. This much more detailed!

[kelkel]

No problem. Had it for a long while and was going to post it on the AAS forum during some pretty contentious discussions over that topic. I refrained so as to not fan the flames.....

[Bonaparte]

Honestly, I don't see any medical benefit over testosterone . Even at 1/3 the dose, Tren just has more side effects than test.

[kelkel]

Honestly, I don't see any medical benefit over testosterone. Even at 1/3 the dose, Tren just has more side effects than test.

Yep...

[m_donnelly]

Honestly, I don't see any medical benefit over testosterone. Even at 1/3 the dose, Tren just has more side effects than test.

I agree.

It'll be interesting to see if we have an influx of people being given Tren . My money says the very first thread has the words "Tren, insomnia, and anxiety" in its subject line.

[kelkel]

That threads been here before! It did not go over well.

[m_donnelly]

Really? A doc actually prescribed Tren for TRT??

That is friggin strange.

[bringndaheat]

It's one compound I've never tried but might give it a run. Good stuff 100%

[kelkel]

Really? A doc actually prescribed Tren for TRT??

That is friggin strange.

That won't happen.

[100%]

That won't happen.

I gotta a guy..... You have to pay him in cash behind the doctors office tho???

[laser]

It ceases to amaze me....
Scientific testing has been around for a long time. But these doctors hand out Anti-psychotic medication without any scientific test, no proof what so ever that the patient needs it. Sad thing, and ignores low Testosterone levels . Ignore the scientific proven facts of how beneficial steroid treatment is.
The Antipsychotic meds have more bad side effect than most other meds. It is the truth, no matter what a persons problem is, they persistently push these mind altering, psychotic drugs, and Cover up the bad effects (Twitching, jerking,tounge lashing,slobbering,random blurting of words, full identity loss, swollen bloated extended stomach,addiction,uncontrollable crying,laughing,sleeping weight gain, anorexia, Black box sucide, anger,and other warnings, etc, the list goes on).. It is a money making scheme, stay away from the doctors, that push this stuff, you can bet they are getting big time PERKS from the drug companies, do not feed them.
My point is, scientific data is good, to bad physicians are ignoring it.