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  1. #1
    jungle1 is offline Junior Member
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    Estered Testosterone vs Natural Testosterone - What's the difference

    ok i was wondering if someone could clarify this for me.... so this is what ive read so far - with synthetic testosterone they have a carbon ester attached to it which allows it to be released periodically in the body this is attached in the synthesising process done by the scientists, the body then strips away the carbon ester allowing the testosterone to be active in the body to do its thing. So how does natural testosterone work then if it doesnt have an ester, wouldnt it be used up very quickly in the morning after its produced leaving you tired for the rest of the day....sorry if this seems a dumb question im just curious?

  2. #2
    2Sox's Avatar
    2Sox is offline Knowledgeable Member
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    My first response to your question is that the body's endocrine system is a highly tuned mechanism with many feedback mechanisms responding to countless signals during the day and over a lifetime. Is it any wonder that in a healthy functioning individual, the body knows how much testosterone is needed - or not needed - at any given moment?

    When the body begins to fail and we get involved and introduce endogenous testosterone, we can't possibly do as good a job - but we try, muddle along, and in the end do alright.

    This is a very good place to begin for further information to answer your question:

    Understanding Esters, Active-Life and Half-Life

    Then try your best friend, Google.

  3. #3
    kelkel's Avatar
    kelkel is offline HRT Specialist ~ AR-Platinum Elite-Hall of Famer ~ No Source Checks
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    Endogenous testosterone is pulsatile and diurnal in nature. It's natural to have a daily rise and fall. Exogenous test isn't thus the ester to control it's release and keep the flow somewhat consistent. Imagine the spike if there was no ester?
    -*- NO SOURCE CHECKS -*-

  4. #4
    Bonaparte's Avatar
    Bonaparte is offline AR-Hall of Famer
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    The missing piece to your puzzle is SHBG. It binds up testosterone and thus slows the rate at which it is utilized.

  5. #5
    2Sox's Avatar
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    Quote Originally Posted by kelkel View Post
    Endogenous testosterone is pulsatile and diurnal in nature. It's natural to have a daily rise and fall. Exogenous test isn't thus the ester to control it's release and keep the flow somewhat consistent. Imagine the spike if there was no ester?
    Thanks, Kel. That there is this pulsatile, diurnal process is so fascinating to me. But it mystifies me too. The body is amazing. I really would like to learn more about how it works.

  6. #6
    jomamma007 is offline Member
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    is it true that a few days out of the month a guys endogenous test is lower then the other days, even if outside factors are unaffected?

  7. #7
    Bonaparte's Avatar
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    Quote Originally Posted by jomamma007 View Post
    is it true that a few days out of the month a guys endogenous test is lower then the other days, even if outside factors are unaffected?
    Where did you hear this?

  8. #8
    jomamma007 is offline Member
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    doctor told me it's normal for swings in testosterone here and there...

  9. #9
    Bonaparte's Avatar
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    Quote Originally Posted by jomamma007 View Post
    doctor told me it's normal for swings in testosterone here and there...
    Sure, since diet, sleep, stress, exercise and other factors all affect daily test output.
    But you made it sound like some sort of monthly manstrual cycle. lol

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