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  1. #1
    Rjay is offline Associate Member
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    Good starting dose for anastrazole?

    I just had blood results come back and me estrogen is just over the top of the range and I have definately felt the effects of high e2 over the last couple weaks such as lots of anxiety, mild depression, energy lower then first month of TRT and lowered libido. I tried going without an AI but I believe I need one considering I havent even included hcg yet. Im wondering what is a good recommended starting dosage for anastrazole to avoid sending my e2 too low.

    50mg cyp E3D

    Estradiol 165 (<156) I know its not Estradiol sensitive but this is what I have to work with

  2. #2
    xcraider37 is offline Associate Member
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    Quote Originally Posted by Rjay View Post
    I just had blood results come back and me estrogen is just over the top of the range and I have definately felt the effects of high e2 over the last couple weaks such as lots of anxiety, mild depression, energy lower then first month of TRT and lowered libido. I tried going without an AI but I believe I need one considering I havent even included hcg yet. Im wondering what is a good recommended starting dosage for anastrazole to avoid sending my e2 too low.

    50mg cyp E3D

    Estradiol 165 (<156) I know its not Estradiol sensitive but this is what I have to work with
    I am not familiar with that estradiol test, but if you want to use adex I would start with a small dose, like .125mg. so an 1/8 of a 1 mg. pill. Most say do a .25 2x per week but I have found that will crash you quickly. IMO it's best to play with your trt dose so you don't have to use adex at all.

  3. #3
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    Quote Originally Posted by xcraider37 View Post
    I am not familiar with that estradiol test, but if you want to use adex I would start with a small dose, like .125mg. so an 1/8 of a 1 mg. pill. Most say do a .25 2x per week but I have found that will crash you quickly. IMO it's best to play with your trt dose so you don't have to use adex at all.
    Solid advice. Spend 5 bucks on a pill cutter! Take your dex the day after each injection for best results.
    -*- NO SOURCE CHECKS -*-

  4. #4
    Rjay is offline Associate Member
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    Im injecting E3D and once I figure out my adex dosage I will be adding hcg so it will look something like this:

    Day1: Cyp 50mg
    Day2:
    Day3: 250iu hcg

    Im thinking of taking the hcg the day before my shot, so I dont have to take too much at once. Sometimes after a shot I feel weird probably from E2 rising a bit but slight brain fog and anxiety (sometimes not always). So kel you recommend the day after based on that?

  5. #5
    Rjay is offline Associate Member
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    Xcraider sounds good I will start with that and titrate from there less is more!

  6. #6
    Rjay is offline Associate Member
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    And I will be willing to play with my TRT dose to get off an AI in the future for now I want to get a proper T and HCG protocol going so I can feel good and this elevated e2 is causing me issues. Once everything is going smooth I can start making some adjustments to see what I can do. My free T is mid range right now which is MUCH improved from prior but Id still like to get it to optimal AND I have yet to add hcg so if E2 is already a problem I can only imagine it won't get any better atm. Im not thinking with my ego, thats why Im going as slow and carefully as I can I understand its a marathon not a sprint.

  7. #7
    gon3r is offline New Member
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    My doctor has had me on .5mg 3x a week for a couple years. I haven't seen any issues at that dosage. I'm taking 140mg of T per week.

    I'm starting to have some libido issues after a couple years so going to get Estradiol level checked out.

  8. #8
    Beethoven's Avatar
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    1/4 of a 1 mg pill the day after injection is what I do. Good starting place but note, if you are starting HCG as well you will need follow up BW to judge as your E2 level is WITHOUT HCG. HCG can also raise your E2 as it does with me.

  9. #9
    Rjay is offline Associate Member
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    Beethoven how often are you injecting? I plan on running my AI for 3 weeks then testing again before I add hcg

  10. #10
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    Quote Originally Posted by Beethoven View Post
    1/4 of a 1 mg pill the day after injection is what I do. Good starting place but note, if you are starting HCG as well you will need follow up BW to judge as your E2 level is WITHOUT HCG. HCG can also raise your E2 as it does with me.
    This is good advice. But I'll go one further. NO dose of anastrozole is a good starting dose! Take Aromasin . This is my opinion and I have good reason for saying so. I tried dancing with Adex for a year and she kept stepping on my toes - big time. Never could work out a good routine so I changed partners! And I'm absolutely overjoyed with the results. If you read other threads on this very subject, it will become clear to you that MANY men have a great deal of difficulty getting this medication to work for them.

    There are many reasons to switch to Aromasin - which is easier to work with and also much more forgiving. And Aromasin does not have the dreaded rebound that Adex has. Adex is more common because it is much cheaper. But if you find an Aromasin protocol that works for you, the cost is not much different - from my experience. I now take 12.5mg every 6 days and I'm doing fantastic. I strongly suggest you consider this.

  11. #11
    Rjay is offline Associate Member
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    Wow ive actually never heard someone speak so highly of aromasin , I hear about anastrozole much more. If I have no luck with it then I will definately take you up on that 2sox!

  12. #12
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    Quote Originally Posted by Rjay View Post
    Beethoven how often are you injecting? I plan on running my AI for 3 weeks then testing again before I add hcg
    I pin Tues p.m. And Sat a.m. A lot of this is trial and error. You have to see what works for you. Adex is powerful so you want to start conservative and work up if needed. Some do better on Aromasin . I recall the battles 2Sox had on Adex and Aromasin worked well for him. Adex has worked for me. Everyone is different, we have many offering our own successes and failures here as information, but ultimately you have to find what works for you.

  13. #13
    gon3r is offline New Member
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    Quote Originally Posted by Beethoven View Post
    1/4 of a 1 mg pill the day after injection is what I do. Good starting place but note, if you are starting HCG as well you will need follow up BW to judge as your E2 level is WITHOUT HCG. HCG can also raise your E2 as it does with me.
    Beethoven, how much T are you taking per week? I'm trying to see the relation between my .5mg vs your .25mg.

    Thanks!

  14. #14
    Beethoven's Avatar
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    Quote Originally Posted by gon3r View Post
    Beethoven, how much T are you taking per week? I'm trying to see the relation between my .5mg vs your .25mg.

    Thanks!
    Gon3r my protocol is 100 mg of test, pinning Tuesday p.m. And Saturday a.m.
    HCG presently at 500 iu's a week pinning on Thursday a.m. I've taken Anastrozole two ways, 1/4 tab day after pinning, and presently 1/2 tab on Sunday a.m. Both ways have worked for me without any noticeable changes.

  15. #15
    gon3r is offline New Member
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    Quote Originally Posted by Beethoven View Post
    Gon3r my protocol is 100 mg of test, pinning Tuesday p.m. And Saturday a.m.
    HCG presently at 500 iu's a week pinning on Thursday a.m. I've taken Anastrozole two ways, 1/4 tab day after pinning, and presently 1/2 tab on Sunday a.m. Both ways have worked for me without any noticeable changes.
    Thanks, I'm not on any HCG , just Test and Anastrozole. I think I'll lower my dose down from the .5mg three x week to .25mg twice x week. With the goal of slowly removing Anastrozole if I can.

  16. #16
    Paragon73 is offline New Member
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    Balancing E2 is the trickiest part of trt. Try dissolving your adex in Everclear or vodka so you can titrate your dose. You'll need to keep track of how you feel and get additional E2 sensitive tests.
    Last edited by Paragon73; 09-21-2014 at 05:26 PM.

  17. #17
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    Quote Originally Posted by Rjay View Post
    Im injecting E3D and once I figure out my adex dosage I will be adding hcg so it will look something like this:

    Day1: Cyp 50mg
    Day2:
    Day3: 250iu hcg

    Im thinking of taking the hcg the day before my shot, so I dont have to take too much at once. Sometimes after a shot I feel weird probably from E2 rising a bit but slight brain fog and anxiety (sometimes not always). So kel you recommend the day after based on that?
    hCG may affect Testosterone levels , so I wouldn't waste time trying to dial in Adex before adding hCG. Add the hCG first, and then work on Adex.

    Usually Adex is recommended after injecting because that's when Testosterone peaks, and aromatization (conversion from Testosterone to E2) is likely to occur.

    More frequent injections might help too!

  18. #18
    Rjay is offline Associate Member
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    Ya but Im already running high e2 levels and feeling some sides from it especially with my energy and moods. My energy is about half of what it was on the first month of TRT (hoping this is e2 related at least), so Id like to get e2 somewhat lower ASAP. And do you mean on the day of injection when you say "recommended after injecting"?

  19. #19
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    Kel recommended the day after. IIRC, Dr. Crisler recommends the day of injection.

    Anastrozole (Adex) kicks in quick for me, so I don't think it matters much.

    If you somehow found the perfect dose, it would no long be valid once you start the hCG . Why not just start the hCG, and pop 0.25mg Adex if needed?

    I tried taking 0.25mg every 4 days for a few weeks, but think it took me too low. Now I'm back to just taking 0.25mg as I feel it's needed.

    E2 didn't cause energy problems for me (as far as I know); for me it usually started with flushing in the face, neck, and upper chest, then night sweats (not the good kind), and then water retention.

    There's more to controlling E2 than just taking an AI. As long as I'm in the upper quartile, I don't worry too much about numbers, so I'm in the process of lowering my Testosterone dose from the 100mg/week that I started on. I expect E2 symptoms should ease with lower Testosterone doses. I've lowered it once already and am doing better, and will most likely be dropping it again in a couple weeks. Will update my thread after blood work.

    Other things to get a handle on include:

    • Booze (especially beer with hops)
    • Obesity
    • Zinc deficiency
    • Vitamin C deficiency
    • Soy
    • Flax seeds


    I found that cutting back on booze helped me out quite a bit. Still have the occasional glass of red wine, but that's about it. A pint of cider doesn't seem to cause problems either.

    Might not hurt to make sure you're drinking enough water. I drink at least a gallon a day.

    Taking Vitamin D3?

    What's your hematocrit?

    How long on TRT?

    Latest Test levels?

    Titrating up or down?

    BF%?

  20. #20
    Beethoven's Avatar
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    Quote Originally Posted by OingoBoingo View Post
    hCG may affect Testosterone levels , so I wouldn't waste time trying to dial in Adex before adding hCG. Add the hCG first, and then work on Adex.

    Usually Adex is recommended after injecting because that's when Testosterone peaks, and aromatization (conversion from Testosterone to E2) is likely to occur.

    More frequent injections might help too!
    Hcg definitely makes my E2 jump. If you plan on adding hcg to your protocol you might as well do it now and get it dialed in with your adex. Establish your protocol and do BW in four weeks.

  21. #21
    Rjay is offline Associate Member
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    Ya I think as needed is the only way to go. My current protocol is 50mg E3D. Im in good shape with about 10% bodyfat, no zinc deficiency, I do drink a lot of water but too much is making me bloat slightly lately. I also find that booze really has a negative effect on me especially mood and anxiety so since being on TRT (2 months) Ive gotten 'drunk' once while in vegas and other then that probably have 2-3 drinks every second week. I want to let the cat out of the bag and admit I am self administering after being shut down by 4 doctors because my testosterone levels were still 'in range' even though my free testosterone was about 8 points being out of the lowest point. I searched for over 2 months while being depressed and completely run down, I am still looking. I do get regular BLOODwork done via my family doctor still which makes me a little more comfortable. Sorry if anyone disagrees with this but I feel like it had to be done for my sanity.

    Oingo as for my latest T levels (via saliva test) my T came back at 243 on a scale of 141-342. This was day 3 so the day before my injection. Thanks for all the feedback

  22. #22
    Rjay is offline Associate Member
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    Also in john crislers TRT recipe for success he says he likes to get patient T levels tuned up with a estrogen level thats in a healthy range with or without an AI and THEN adds HCG into the mix. You guys dont agree? Adjust AI once HCG is incorporated? Im not really excited about the idea of lowering my T as I still would like it slightly higher. Injecting ED is a possibility but very undesirable in my eyes seeing as I like to travel and already feel like E3D is a lot

  23. #23
    Beethoven's Avatar
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    Quote Originally Posted by Rjay View Post
    Also in john crislers TRT recipe for success he says he likes to get patient T levels tuned up with a estrogen level thats in a healthy range with or without an AI and THEN adds HCG into the mix. You guys dont agree? Adjust AI once HCG is incorporated? Im not really excited about the idea of lowering my T as I still would like it slightly higher. Injecting ED is a possibility but very undesirable in my eyes seeing as I like to travel and already feel like E3D is a lot
    Either way you will probably have to increase your Adex once you start HCG , it'll just take longer to get it dialed in.

  24. #24
    Rjay is offline Associate Member
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    Ya you guys make sense. I took about .20mg of liquidex with my shot yesterday and didnt notice any ill effects. Im not sure how long arimidex takes to lower estrogen. I will take hcg the same time I take my next shot and try and get them dialed in together seeing as I will be using both anyways.

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