Anastrozole and low E2, how long to bounce back

[bluskiblacdeth]

Had blood work done 2 weeks ago. Everything came back great, best its ever been. T at all the top of the ranges and everything else looking great except E2 which came in at 12 with a range of 11-44. I know I feel best in the 20-22 range and get moody, burning nips and aches if it goes higher. Been feeling pretty good but since the blood work I have taken 2 additional doses of Anastrozole (1/4mg day after injections...two doses while waiting on test results). Anyhow I'm sure it dropped lower and man o man am I feeling it. Achy achy achy, moody moody moody. Doc wants me to drop to 1/4mg once a week and see how I feel. I plan on skipping my next two doses and then start back with 1/4mg once a week. My question is how long should I expect my E2 to bounce back up?....feeling rough.

[Beethoven]

Had blood work done 2 weeks ago. Everything came back great, best its ever been. T at all the top of the ranges and everything else looking great except E2 which came in at 12 with a range of 11-44. I know I feel best in the 20-22 range and get moody, burning nips and aches if it goes higher. Been feeling pretty good but since the blood work I have taken 2 additional doses of Anastrozole (1/4mg day after injections...two doses while waiting on test results). Anyhow I'm sure it dropped lower and man o man am I feeling it. Achy achy achy, moody moody moody. Doc wants me to drop to 1/4mg once a week and see how I feel. I plan on skipping my next two doses and then start back with 1/4mg once a week. My question is how long should I expect my E2 to bounce back up?....feeling rough.

It all depends on how much your E2 spikes. If your dose is going to be 1/4 a week you may not need it at all. You'll bounce back certainly after your second shot. I crashed mine a while back, and it started to climb at my next shot. I was heavier then and aromatized more than now.

[bullshark99]

If I were you I would ditch it all together and retest in 6 weeks and go from there. I highly doubt that small dose is preventing you from going to 50, see where you fall, may not need it at all

[Trevtrev]

Just a note, when I switched from compounded 1/4mg anastrozole and the liquid stuff to the 1mg tabs (broken into quarters of course) it crashed my E2 while on trt doses of test (40mg 2x/wk) taking .25 the day after my t injections.

The real deal from the pharmacy is strong. Be advised. 1/8mg on lower trt doses seems to be a better starting point and work up as needed. Use a pill cutter.

I'm trying something different now where hopefully I won't need an AI.

[2Sox]

Had blood work done 2 weeks ago. Everything came back great, best its ever been. T at all the top of the ranges and everything else looking great except E2 which came in at 12 with a range of 11-44. I know I feel best in the 20-22 range and get moody, burning nips and aches if it goes higher. Been feeling pretty good but since the blood work I have taken 2 additional doses of Anastrozole (1/4mg day after injections...two doses while waiting on test results). Anyhow I'm sure it dropped lower and man o man am I feeling it. Achy achy achy, moody moody moody. Doc wants me to drop to 1/4mg once a week and see how I feel. I plan on skipping my next two doses and then start back with 1/4mg once a week. My question is how long should I expect my E2 to bounce back up?....feeling rough.

I keep on saying it but it bears repeating. Adex is VERY strong stuff. Develop a healthy respect for it. Better yet, get some Aromasin /exemestane instead. Easy in every way. You'll be glad you did. I switched and never looked back.

[Heapsreal]

Add some extra dhea for a short while until arimidex is out of your system and then lower the dhea etc. Might help you with the muscle and joint pain. Massage and pain killlers just dont help i have found when this happens, increasing dhea did???

[2Sox]

Add some extra dhea for a short while until arimidex is out of your system and then lower the dhea etc. Might help you with the muscle and joint pain. Massage and pain killlers just dont help i have found when this happens, increasing dhea did???

Wow. That's a first. How do you explain the results?

[Heapsreal]

it might be just me, but dhea aromatises to E2 easily in me. I still use dhea because i tested well below the normal range. I have been able to avoid the E2 issues with it when just on dhea by using smaller doses like 25mg twice a day instead of say 50mg once a day.
But i used this info and experience when my e2 crashed on arimidex which at the time i was using to control the E2. It was a juggling act at frst to get it sorted.

Now on T i just use small doses of arimidex .25mg twice a week, i might be a sensitive responder to arimidex too?

[2Sox]

^^^ Never heard of DHEA converting to E2. Couldn't find any data on this. Someone please enlighten me.

And if you are watching your blood work and your DHEA-S is within range, I would say there is no issue.

[lovbyts]

^^^ Never heard of DHEA converting to E2. Couldn't find any data on this. Someone please enlighten me.

And if you are watching your blood work and your DHEA-S is within range, I would say there is no issue.

I have read it on here also but cant find it right now.

J Clin Endocrinol Metab. 1999 Jun;84(6):2170-6. [PMID: 10372727]

Biotransformation of oral dehydroepiandrosterone in elderly men: significant increase in circulating estrogens.

Arlt W, Haas J, Callies F, Reincke M, Hubler D, Oettel M, Ernst M, Schulte HM, Allolio B.

The author makes a series of statements in which he cites the 1997 Labrie study (above), saying:

"Labrie et al. (19) administered a 20% DHEA cream in a daily dose of 10 mL for 14 days to a total of eight elderly men and women and found no significant increase in serum estrogen levels in either gender. These results differ from the findings of our study and those of Young et al. (18), but may be explained by the route of DHEA administration. As previously reported for transvaginal (20) and sublingual (13) administration of DHEA, Labrie et al. (18) also described an increased DHEA/DHEAS ratio after percutaneous DHEA administration compared to oral ingestion. Although many tissues contain sulfotransferases (21, 22) and may contribute to the peripheral conversion of DHEA to DHEAS, the hepatic sulfotransferase activity seems to be of predominant importance and is bypassed by nonoral DHEA administration due to avoidance of the hepatic first pass effect. An increased DHEA/DHEAS ratio may lead to a reduced conversion of DHEA to androgens and/or estrogens inside peripheral target cells, as DHEAS has a much longer half-life than DHEA, and it can be continuously converted back to DHEA by widespread tissue sulfatase activity (23, 24, 25, 26) followed by further bioconversion. Furthermore, avoidance of the first pass effect by nonoral administration of DHEA also leads to avoidance of hepatic aromatase and 5-reductase activities. This may explain a lack of conversion to estrogens in men as well as the reduced conversion to androgens in women after percutaneous DHEA administration (19). This view is supported by the data of Casson et al. (20), who found an increase in DHEA, but not in DHEAS and T, after transvaginal DHEA administration. Serum estrogen levels were not reported in this study (20).

Biotransformation of Oral Dehydroepiandrosterone in Elderly Men: Significant Increase in Circulating Estrogens



http://press.endocrine.org/doi/full/...jcem.84.6.5789