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  1. #1
    sportsfan8724 is offline New Member
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    e2 vs e2 ultra sensitive

    I am trying to better understand the change in theory now that everyone is saying using ultra sensitive is better. For years all studies and hrt have used 20-30 as the range where guys feel best. Life extensions research also shows all their studies all used the standard estradiol test . So if all the research and trt over the years has used the regular estradiol test and found 20-30 to be the best range how is the ultra sensitive test better when it is normally way different results then then regular test. If we were say 25 on the ultra e2 test that would put us at probably around 50 on a regular estradiol test which is way over what is considered healthy based on all studies that have been done. Hopefully someone can help me understand this better because I find estradiol to be by far the most controversial and confusing part of trt.

  2. #2
    OingoBoingo's Avatar
    OingoBoingo is offline Member
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    The argument for the sensitive test is that the standard is not accurate on the far ends of the bell curve. Some have said that the standard test can be as much as 10 points higher causing men to take an AI needlessly.

    I have heard Dr. Crisler and Dr. Gordon speak in favor of sensitive testing a few times, and as much as I respect those guys, I have trouble buying into the argument.

    The sensitive test is not available where I live, so I have been using the standard test for the last 10 months or so. I only take Anastrozole when experiencing sides. It's my experience that standard testing at my hospital seems accurate and consistent.

    And as you pointed out, LEF currently recommends the standard test. Although, if Crisler is still on the board, it's a good bet he's lobbying for a change.

    If one experiences sides, it makes managing E2 so much easier; just take an AI when needed. Guys can get into trouble when they start thinking that they need to be on a weekly schedule. Once a week can work well for guys that inject Testosterone once per week. But for guys injecting more often, E2 acts a little differently.

    I currently inject Testosterone daily, and track E2 issues and Anastrozole consumption on a calendar. I found that when I first started TRT, I was taking Anastrozole 0.25mg about every 8 days. Over time (and supplementing with Zinc, and reducing alcohol intake), that rate slowed to once every 12 or 14 days.

    I understand some guys don't experience E2 sides, but if you do, listen to your body.

    Hope that helps.

  3. #3
    Chauffeur is offline Associate Member
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    To add to the above comment...

    I can't recall where I read this, but apparently Dr. Crisler is working on getting LEF to change their recommendation regarding the standard test.

    I don't trust the standard assay at all. There has been as much as a 20 point difference between the standard and sensitive assay for me.

    If you read Labcorp's descriptions, they say that the sensitive assay is recommended for men. I'm inclined to stick with what the lab, and my doctor recommend.

  4. #4
    sportsfan8724 is offline New Member
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    Ok the confusion is all the studies and research on estradiol in men has said 20-30 on the standard test. It says higher then 30 is bad for prostate etc. So why are we now saying that's too low? And even if Crisler talks life extension into changing there test the studies they have done are all based on the basic test which shows 20-30 is where the lowest death rates occur.

  5. #5
    Lee_1978's Avatar
    Lee_1978 is online now Associate Member
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    I had no idea there was an ultra sensitive oestrogen test?

  6. #6
    kelkel's Avatar
    kelkel is offline HRT Specialist ~ AR-Platinum Elite-Hall of Famer ~ No Source Checks
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    Quote Originally Posted by OingoBoingo View Post
    I have heard Dr. Crisler and Dr. Gordon speak in favor of sensitive testing a few times, and as much as I respect those guys, I have trouble buying into the argument.

    And as you pointed out, LEF currently recommends the standard test. Although, if Crisler is still on the board, it's a good bet he's lobbying for a change.
    They recommend the standard as it's all about money. About $20 compared to $200 (from memory)


    Quote Originally Posted by Chauffeur View Post
    To add to the above comment...

    I can't recall where I read this, but apparently Dr. Crisler is working on getting LEF to change their recommendation regarding the standard test.

    I don't trust the standard assay at all. There has been as much as a 20 point difference between the standard and sensitive assay for me.

    If you read Labcorp's descriptions, they say that the sensitive assay is recommended for men. I'm inclined to stick with what the lab, and my doctor recommend.
    Crisler is still working toward it. Discountedlabs .com (Nelson's creation) offers it cheaper than anywhere else I've seen so far. Whatever test you choose, and I always go sensitive, be consistent otherwise you're just confusing yourself.
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