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Thread: TRT and pituitary gland

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    Slacker78's Avatar
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    TRT and pituitary gland

    Hello guys. I just wondering when someone get in TRT, being endogenous LH production will be suppressed for a long time ( forever ), this will cause a progressive and irreversible atrophy process of the pituitary gland ?

    Beyond HCG and exogenous Testosterone administration and its impact on testicles, what will happen in time to pituitary gland... i suppose it will loose the ability to product LH forever.....

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    Quote Originally Posted by Slacker78 View Post
    Hello guys. I just wondering when someone get in TRT, being endogenous LH production will be suppressed for a long time ( forever ), this will cause a progressive and irreversible atrophy process of the pituitary gland ?

    Beyond HCG and exogenous Testosterone administration and its impact on testicles, what will happen in time to pituitary gland... i suppose it will loose the ability to product LH forever.....
    Pituitary cells can increase and shrink in number at any moment in life depending on stimulation from hypothalamic release factors, or lack thereof.

    In the case of LH it's reasonable to envisage a reduction in number of gonadotrope (both FSH and LH producing) cells, but this is ultimately the result of cessation of GnRH input from the hypothalamus via the pituitary stalk... if that were to resume then any change to above cells would likely be reversed.
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    Quote Originally Posted by bizzarro View Post
    Pituitary cells can increase and shrink in number at any moment in life depending on stimulation from hypothalamic release factors, or lack thereof.

    In the case of LH it's reasonable to envisage a reduction in number of gonadotrope (both FSH and LH producing) cells, but this is ultimately the result of cessation of GnRH input from the hypothalamus via the pituitary stalk... if that were to resume then any change to above cells would likely be reversed.
    So there's no irreversible block/suppression of pituitary gland in long term, even i think there's no also any guarantee of a full reversibility of the whole stack.

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    Youthful55guy is offline Knowledgeable Member
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    Quote Originally Posted by Slacker78 View Post
    So there's no irreversible block/suppression of pituitary gland in long term, even i think there's no also any guarantee of a full reversibility of the whole stack.
    To my knowledge, it's never been studied. My gut reaction is that I don't think there is irreversible damage, but that's just a guess.
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    kelkel is offline HRT Specialist ~ AR-Platinum Elite-Hall of Famer ~ No Source Checks
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    Shrinkage won't occur at all unless blood flow ceased. If that occurs then you've got much bigger issues to deal with.........like making sure I'm in your will before this occurs, etc...
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