Estrogen was 226! Dr put me on....

[Mattyx1001]

Ive been on TRT for 8 years now. I take generic androgel which I love but the last year my dick has been like spaghetti. Im super horny but it doesn't work when I want it to.
Anyways I got my bloodwork back and my levels: 46 year old male, 15 % body fat, Total Test 856, Free Test 18.9, estrogens total 226! All other bloodwork was good, cholesterol, PSA etc
Question is I know my total test was a bit high but I know how much gel to do daily to put me back in the 500 range, so Im doing that. Dr put me on anastrozole 1mg every other day to lower estrogen. He said I should feel much better in the next 2 weeks, has anyone had this experience? Im hoping my erections come back consistent. thanks for any info

[Gallowmere]

You doctor is likely an idiot.
Was the test for ultra sensitive estradiol?
If not, it’s useless.

[Joe Rogers]

Ive been on TRT for 8 years now. I take generic androgel which I love but the last year my dick has been like spaghetti. Im super horny but it doesn't work when I want it to.
Anyways I got my bloodwork back and my levels: 46 year old male, 15 % body fat, Total Test 856, Free Test 18.9, estrogens total 226! All other bloodwork was good, cholesterol, PSA etc
Question is I know my total test was a bit high but I know how much gel to do daily to put me back in the 500 range, so Im doing that. Dr put me on anastrozole 1mg every other day to lower estrogen. He said I should feel much better in the next 2 weeks, has anyone had this experience? Im hoping my erections come back consistent. thanks for any info

Yes actually. It is a shitty experience. At one point I had my test levels down at 100 and my estrogen over 400.

Point is, the dr doesn’t know your body. The arimidex along with cialis worked to fix me up. Arimidex SHOULD start working immediately but you may have to play with the dose (keep your dr in the loop). First step in knowing if you’re getting balanced (from my experience) is that you’ll start getting erections in the morning again. Then you’ll know you hit the sweet spot. Took me a couple of days on arimidex before this happened. Once you stop getting them in the morning, you may need to stop arimidex or adjust dosage because you’ve come out of tolerance. If your insurance is covering it (mine does) I would get my blood work taken every week to monitor and adjust dosage. Arimidex is very potent and could crash your estrogen as well. Keep us posted please.


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[Mattyx1001]

ok thanks, are saying get my blood tested for E2 levels? Don't take the 1 mg every other day till I see what my E2 levels are?

[Joe Rogers]

ok thanks, are saying get my blood tested for E2 levels? Don't take the 1 mg every other day till I see what my E2 levels are?

I would take as prescribed. Your estrogen is still out of tolerance and arimidex will help with that. I’m saying you should try to get weekly blood work so you don’t over do the arimidex. E2 is what plays an impact specifically on sexual functionality. So you’d need to get that tested specifically to pin point.


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[C27H40O3]

Yeah. Get it right. My E2 went too high and I lost my morning erections. Then too much an anastrozole crashed it and I felt even worse. That scared me so much I gave up the AI and the E2 stays acceptable now. For me, a bit too high was way better than very low.

This whole E2 shit seems like it is more voodoo than science to me. So many have problems getting it just right.


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[Youthful55guy]

Ive been on TRT for 8 years now. I take generic androgel which I love but the last year my dick has been like spaghetti. Im super horny but it doesn't work when I want it to.
Anyways I got my bloodwork back and my levels: 46 year old male, 15 % body fat, Total Test 856, Free Test 18.9, estrogens total 226! All other bloodwork was good, cholesterol, PSA etc
Question is I know my total test was a bit high but I know how much gel to do daily to put me back in the 500 range, so Im doing that. Dr put me on anastrozole 1mg every other day to lower estrogen. He said I should feel much better in the next 2 weeks, has anyone had this experience? Im hoping my erections come back consistent. thanks for any info

First place I'd start before taking any AIs is to make sure the doctor ordered the correct test. It needs to be the sensitive test designed for men, preferably one that uses LC/MS/MS methodology rather than immunoassay technology. An E2 level of 226 with normal T labs seems like an anomalous measurement. Double check it's correct before taking an AI (and throwing the measurement off) and then if it is still too high (using the correct lab) than consider layering in an AI.

[kelkel]

ok thanks, are saying get my blood tested for E2 levels? Don't take the 1 mg every other day till I see what my E2 levels are?

Yes, obtain a sensitive e2 assay first. Total estrogen combines estradiol and estrone. Estradiol is stronger than estrone and is what needs to be checked like the guys above said. Do not initiate 1 mg adex eod. Horrible protocol that will completely crash your estrogen levels. Estrogen is needed in men for a variety of reasons including libido. It's also anabolic . Always better to be a little higher than lower.

[charger69]

It's also anabolic. Always better to be a little higher than lower.

I wanted to point out the above. It may have gotten lost with the other comments.


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[Youthful55guy]

I wanted to point out the above. It may have gotten lost with the other comments.


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Adding to this discussion, here's an excerpt on a very well written discussion on the roll of estrogen in men (From <https://www.discountedlabs.com/blog/post/blog_the_top_18_things_you_did_not_> )

Estrogen and its beneficial effects in bodybuilding

Estrogen, one of the most important female sex hormone, is vital for professional athletes who aim at increasing their muscle mass.
For example, estrogen can increase the anabolic response by modifying the way glucose is processed in muscle tissue.
This hormone can influence the amounts of glucose 6-phosphate dehydrogenase which is directly correlated to muscle growth and repair. In other words, having adequate amounts of estrogen can maximize muscle gains and strength.

In studies performed on rats, estrogen has also been correlated with a whopping 480% increase in methyltrienolone which is an androgen connected to the levator ani muscle.

The production of growth hormone and IGF-1 (insulin -like growth factor) are also influenced by estrogen. This female sex hormone can increase the proliferation of IGF-1 in body tissues and liver which leads to greater muscle gains and protein synthesis.

Estrogen also plays an important role when it comes to serotonin production. Serotonin is known for regulating the sleep/waking cycle.

Bodybuilders who take aromatase inhibitors as drugs might have low levels of estrogen in the body. This can alter the serotonin production and lead to a thing called “steroid fatigue”.

This is usually characterized by a general feeling of tiredness which can interfere with training regimes and prevent the athlete from performing at his peak. Maximizing muscle gains can be difficult in this case.
Some of the drugs which inhibit aromatase and can lead to “steroid fatigue” are anastrozole, letrozole and fadrozole. This happens if they are taken in high quantities, above the prescribed dosage and for long period of times.

[Gallowmere]

Adding to this discussion, here's an excerpt on a very well written discussion on the roll of estrogen in men (From <https://www.discountedlabs.com/blog/post/blog_the_top_18_things_you_did_not_> )

Estrogen and its beneficial effects in bodybuilding

Estrogen, one of the most important female sex hormone, is vital for professional athletes who aim at increasing their muscle mass.
For example, estrogen can increase the anabolic response by modifying the way glucose is processed in muscle tissue.
This hormone can influence the amounts of glucose 6-phosphate dehydrogenase which is directly correlated to muscle growth and repair. In other words, having adequate amounts of estrogen can maximize muscle gains and strength.

In studies performed on rats, estrogen has also been correlated with a whopping 480% increase in methyltrienolone which is an androgen connected to the levator ani muscle.

The production of growth hormone and IGF-1 (insulin -like growth factor) are also influenced by estrogen. This female sex hormone can increase the proliferation of IGF-1 in body tissues and liver which leads to greater muscle gains and protein synthesis.

Estrogen also plays an important role when it comes to serotonin production. Serotonin is known for regulating the sleep/waking cycle.

Bodybuilders who take aromatase inhibitors as drugs might have low levels of estrogen in the body. This can alter the serotonin production and lead to a thing called “steroid fatigue”.

This is usually characterized by a general feeling of tiredness which can interfere with training regimes and prevent the athlete from performing at his peak. Maximizing muscle gains can be difficult in this case.
Some of the drugs which inhibit aromatase and can lead to “steroid fatigue” are anastrozole, letrozole and fadrozole. This happens if they are taken in high quantities, above the prescribed dosage and for long period of times.

Couldn’t get the page to load, but I hope they at least credited that to it’s source.
It’s a verbatim rip from William Llewellyn’s Anabolics. Heh.

[Youthful55guy]

Couldn’t get the page to load, but I hope they at least credited that to it’s source.
It’s a verbatim rip from William Llewellyn’s Anabolics. Heh.

Try a copy/paste of the address now. I edited some of the extraneous text out of the web address. Works for me anyway.

They credit the article to someone named Nick Gold but no source. Perhaps the have a common source. Don't know, but it's rich in information.