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Thread: Anyone experience Low Estradiol levels?

  1. #1
    polly56's Avatar
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    Anyone experience Low Estradiol levels?

    Hello,

    I was wondering if anyone has experienced managing low estrogen levels. I'm 35, I've ran 3 cycles in the past - this was over 7 years ago. I recently had some concerns about low testosterone levels - Low energy, anxiety, low libido and ED.

    Blood work showed:

    SHGB 31nmol/L
    test bioavailable 9 nmol/L
    Free test 386 pmol/L
    test 17.8 nmol/L

    Estradiol <40 pmol/L

    received a referral to see an endocrinologist, wait list to see him is 10 months.

    If anyone has any experience or feedback please let me know.

    Thanks
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    Quote Originally Posted by polly56 View Post
    Hello,

    I was wondering if anyone has experienced managing low estrogen levels. I'm 35, I've ran 3 cycles in the past - this was over 7 years ago. I recently had some concerns about low testosterone levels - Low energy, anxiety, low libido and ED.

    Blood work showed:

    SHGB 31nmol/L
    test bioavailable 9 nmol/L
    Free test 386 pmol/L
    test 17.8 nmol/L

    Estradiol <40 pmol/L

    received a referral to see an endocrinologist, wait list to see him is 10 months.

    If anyone has any experience or feedback please let me know.

    Thanks
    It's a good idea to include ranges with your bloodwork numbers.

    There are a couple of observations I can make though.

    That does not look like the sensitive estradiol test. Men need the sensitive one.

    That estradiol number doesn't tell me anything. Less than 40... OK, how much les than 40? Is it 39 or is it 3? That's a pretty big range - towards the upper end isn't likely a problem, towards the lower end is.

    See if you can retest and get the estradiol sensitive test.

    Also be aware that in general, test and estrogen will stay in line with each other, in the absence of exogenous drugs altering that relationship.
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    ok - These are the ranges...

    SHGB 31nmol/L 10-70 nmol/L
    test bioavailable 9 nmol/L 3.6- 11.2 nnmol/L
    Free test 386 pmol/L 196- 636 pmol/L
    test 17.8 nmol/L 8.4 - 28.8 nmol/L

    Estradiol <40 <162

    Yes, unfortunately I didn't get the sensitive one.

    Thanks

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    Quote Originally Posted by polly56 View Post
    ok - These are the ranges...

    SHGB 31nmol/L 10-70 nmol/L
    test bioavailable 9 nmol/L 3.6- 11.2 nnmol/L
    Free test 386 pmol/L 196- 636 pmol/L
    test 17.8 nmol/L 8.4 - 28.8 nmol/L

    Estradiol <40 <162

    Yes, unfortunately I didn't get the sensitive one.

    Thanks
    Your numbers look kind of middle of the road. Could you benefit from TRT? Eh, yeah, assuming you are done having kids, then yeah.

    Note that what we talk about as TRT on this board is typically more like "hormone optimization", not vanilla TRT. What I mean is we tend to look at the big picture, not just a number or two, and then maximize our pros and minimize our cons across the board. This is why you will see the recommendations for different blood work, etc

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    Good info, thank you

    With my blood work, do you think its normal to experience ED?
    Do you think I'm experiencing ED due to my past experience using AAS?

    Thanks,
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    Quote Originally Posted by polly56 View Post
    Good info, thank you

    With my blood work, do you think its normal to experience ED?
    Do you think I'm experiencing ED due to my past experience using AAS?

    Thanks,
    I don't know on the first question. We need a legit estrogen reading to know. Estrogen controls the male libido to a large degree, finding the sweet spot can be tricky but it's doable in time.

    Second question, eh, probably not. That was 7 years ago.

    I would say re-run some blood work. Make sure to get the following (in addition to what you have):
    DHT
    Thyroid panel
    CBC
    Lipid panel

    It would be nice to see what is going on here. Is the root of your issue physiological or psychological? Thyroid issues can masquerade as low t issues, as can low DHT. Are you on a 5-alpha reductase inhibitor like finasteride or dutasteride, maybe?

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    Quote Originally Posted by Cylon357 View Post
    I don't know on the first question. We need a legit estrogen reading to know. Estrogen controls the male libido to a large degree, finding the sweet spot can be tricky but it's doable in time.

    Second question, eh, probably not. That was 7 years ago.

    I would say re-run some blood work. Make sure to get the following (in addition to what you have):
    DHT
    Thyroid panel
    CBC
    Lipid panel

    It would be nice to see what is going on here. Is the root of your issue physiological or psychological? Thyroid issues can masquerade as low t issues, as can low DHT. Are you on a 5-alpha reductase inhibitor like finasteride or dutasteride, maybe?
    I'll second what Cylon posted, especially the DHT.
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    Oh and BTW, OP to answer the original question: yes, a lot of us have experienced low estrogen, typically by over usage of AI and / or compounds with estrogen control properties. I DEFINITELY have. To be honest, it kind of sucks but hasn't been QUITE as bad for me as the picture is painted, though it isn't a cake walk. Mind you that people do respond differently so I absolutely do not want to paint the picture that low e is fun.

    That said, in my case, it has typically been one of those things that kind of creeps up over the course of 4 to 6 weeks or so. About 6 weeks ago, I tanked my estrogen (3 on the estradiol sensitive scale) but it took a while to do it. I kind of noticed libido not being great, and kind of lacking motivation. Got the bloods, saw the number, dropped the compounds causing issues. Within 2 to 3 weeks, I was ready to shag a hole in a cinder block wall. Now, not as much, so I'm still trying to dial in my protocol and numbers. It's the long game that counts in TRT.

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    Quote Originally Posted by almostgone View Post
    I'll second what Cylon posted, especially the DHT.
    Man, that one gets overlooked way too often.

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