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10-06-2005, 11:46 AM #1Banned
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- Aug 2005
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oral replacement for insulin ;Glucaphage and Phenformin
Would be great to hear hear from any guys,who have used these two,with experiences or any extra information.
goose4....
Phenformin
Phenformin, also known as Debeone, is an oral hypoglycemic drug that can be found in either 25 mg tablets or 50 mg capsules. This drug was initially developed to control severe cases of type II diabetes, but was discontinued for use in 1977, as it was found to cause lactic acidosis, which left untreated can be fatal. Phenformin will increase the body’s ability to transport glucose into muscle cells by increasing insulin sensitivity, and will inhibit glyconeogenesis in the liver. Phenformin is similar to Glucophage, covered earlier except that Phenformin is considered to be much stronger (as much as 5 to 10 times stronger).
In bodybuilders, Phenformin is used as an oral form of insulin, as it will cause greater glycogen super-compensation during high-carbohydrate bulking diets and will lower blood glucose during cutting phases. There are harsh side effects associated with this drug, including a metallic taste in the mouth, nausea, vomiting, and lactic acidosis. Lactic acidosis has a mortality rate of close to 75% of all individuals who contract the disease. This disease is caused by a buildup of lactic acid in the blood leading to an increase in the acidity of the blood itself (a condition called acidosis). Cells produce lactic acid when they use glucose for energy in the absence of adequate oxygen. If too much lactic acid is present in the body, the balance tips and the individual begins to feel ill. The signs of lactic acidosis are deep and rapid breathing, vomiting, and abdominal pain.
Glucaphage
Glucaphage, also known as Mellitron, is the brand name for metformin, an oral hypoglycemic drug. Initially, Glucaphage was manufactured to be used to control adult onset diabetes mellatus, as it will increase the body’s ability to transport glucose into skeletal muscle by increasing insulin sensitivity. This drug is structurally similar to another hypoglycemic drug, Phenformin, although the latter is stronger (5 to 10 times) than Glucaphage. In the bodybuilding community, Glucaphage is used as an oral replacement for insulin as it will cause greater glycogen supercompensation during high carb days as well as for use to lower blood glucose to induce ketosis more easily.
Common side effects include a metallic taste in the mouth, nausea and vomiting. An effective dose appears to be 1,700 mg divided throughout the day taken with meals. On the black market, Glucaphage is quite expensive. Buyers should expect to pay $3 a pill. Since Glucaphage comes in bottles containing 40 pills, one box can cost as much as $120. Incidentally, this drug is commonly used with creatine in an effort to increase the uptake of creatine to skeletal muscle, although studies investigating this relationship have not been conducted.
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10-06-2005, 12:01 PM #2
very far fom slin effectiveness.
exists avandia too (better)
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