Hexrelin and Cortisol

**deadliftin00** · 03-01-2007, 06:38 PM

I have been doing some research lately trying to set up my next bridge. I did GH last time, and until I can find another good source for kits, I'm leaning towards Hexarelin/GHRP-6 this time around.

I've found some articles floating around (google "hexarelin cortisol") and there seems to be a bunch of info directly indicating that hexarelin spikes your cortisol levels? Obviously I am concerned about anything that is going to raise my cortisol levels 4 fold. Can anyone give any insight here? Are the levels enough to matter, or out of the norm for the flux of cortisol? Is is "out-weighed" or blocked by the GH secretion?

http://jcem.endojournals.org/cgi/con...ract/82/8/2439

http://www.medscape.com/medline/abstract/8954038

**deadliftin00** · 03-02-2007, 05:09 PM

No comments here?

**jbarkley** · 03-04-2007, 10:52 AM

This discusses the Hexarelin, but doesn't address the issue of Acth and cortisol increases:
Hexarelin is a six-amino acid peptide that significantly releases growth hormone . Studies have shown that hexarelin is actually more effective and longer lasting than growth hormone releasing hormone (GHRH). It is also known that GHRP-6 has a synergistic effect with GHRH, causing a far greater release than either of these substances alone. By combining GHRP-6 with Hexarelin, a more potent GH releasing peptide combination is created than ever heard of. The potential clinical usefulness of these GH releasing hexapeptides is also reinforced by observations that long-term administration produces elevations in circulating IGF-1 concentrations. Long term treatment with GHRP-6 similarly has been shown to elevate serum IGF-1 as well as IGF-binding protein-3 concentrations, alter body composition and promote linear growth.

Hexarelin and other GH secratogues show similar potential usefulness by clinical observations that long-term administration produces elevations in circulating IGF-1 concentrations. For example, significant increases in plasma IGF-1 concentrations were noted after 7 days of hexarelin infusion and have even been reported after 7 days of intranasal administration in children and in adults after 7 to 14 days of intranasal hexarelin administration. It is also of interest that long-term administration of hexarelin has been shown to significantly increase circulating GH concentrations as well. The potential clinical utility of these GH secratogues is due to the consistent clinical verification of these findings in individuals of many ages.

**deadliftin00** · 03-04-2007, 11:23 AM

Thanks man. I've also read stuff like that, that makes it sound like "the bomb shit" if you will. But then, I read the abstracts linked above, and noticed that this stuff seemed to also spike cortisol pretty badly - which I would assume would significantly counteract lean muscle gain and fat loss.

**jbarkley** · 03-04-2007, 01:03 PM

Absolutley, then you have to add something to block cortisol, you have to be a biochemist to keep up with all of it.

**deadliftin00** · 03-04-2007, 05:55 PM

Yeah, my first inclination was to just throw clen in at 60 a day just to block the cortisol... But I have no idea if clen's cortisol blocking effect is subject to the 2 week downregulation of the beta receptors... Any other cortisol blockers that would be better suited?