Why does HGH cause sore wrists?

[Rayna]

Just wondering if anyone knows what causes this side to happen?

[Spyeyes007]

Musculoskeletal pain seems to be a common thing with the use of rh-GH and IGF-1, I will do some research to see if I can find the cause. There could be a correlation in an increased growth of bone and connective tissue.

rh-GH (Pharmacutical Insert Adverse Reactions)

Arthralgia (13—23%), myalgia (5—15%) , musculoskeletal pain (5—11%), pain and stiffness of the extremities (7.9—14.7%), back pain (3—10%), weakness, and headache (7.7—18.3%) have been commonly associated with somatropin therapy. Some events appear to occur more frequently in adults than in children, particularly arthralgia. In adults treated with somatropin, muscle and joint pain usually occurred early in therapy and tended to be transient or respond to dosage reduction. Pain, swelling and/or stiffness may resolve with analgesic use or a reduction in frequency of dosing with somatropin. In addition, carpal tunnel syndrome (nerve entrapment syndrome), paresthesias (6.7—13%), and hypoesthesia (6—11%) have also been reported.
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IGF-1 (Pharmacutical Insert Adverse Reactions)
Greater than 5% of patients reported musculoskeletal pain, pain in extremity, and arthralgia, including knee pain (10%), during treatment with mecasermin. Patients should be advised to report any sudden onset of limp with or without hip or knee pain, as these may be symptoms of a slipped capital femoral epiphysis.

[Timm1704]

basically the use of GH causes a fluid build-up, or water retention, in the joints, and are well-known to press upon nerves in the lower arm region, which in turn causes the pain and numbness of which you speak of.

[Ready2Learn]

I agree with Timm.

The theory of it being due to circumferential growth in the wrist does not hold imo, due to the fact that if you discontinue use of the GH, the wrist pain will go away.
As far as i am aware, circumferential growth is permanent.

While we're on this topic:
Anyone know if the enlargement of internal organs is permanent?